| Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51 SS Gunatilleke, CM Calvet, JB Johnston, CK Chen, G Erenburg, J Gut, ... Public Library of Science 6 (7), e1736, 2012 | 73 | 2012 |
| A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease BP Olivieri, JT Molina, SL de Castro, MC Pereira, CM Calvet, JA Urbina, ... International journal of antimicrobial agents 36 (1), 79-83, 2010 | 71 | 2010 |
| SB-431542, a Transforming Growth Factor β Inhibitor, Impairs Trypanosoma cruzi Infection in Cardiomyocytes and Parasite Cycle Completion MC Waghabi, M Keramidas, CM Calvet, M Meuser, MNC Soeiro, ... Antimicrobial agents and chemotherapy 51 (8), 2905-2910, 2007 | 69 | 2007 |
| Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents JY Choi, CM Calvet, SS Gunatilleke, C Ruiz, MD Cameron, JH McKerrow, ... Journal of medicinal chemistry 56 (19), 7651-7668, 2013 | 66 | 2013 |
| CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM) A Debnath, CM Calvet, G Jennings, W Zhou, A Aksenov, MR Luth, ... PLoS neglected tropical diseases 11 (12), e0006104, 2017 | 64 | 2017 |
| 4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency CM Calvet, DF Vieira, JY Choi, D Kellar, MD Cameron, JL Siqueira-Neto, ... Journal of medicinal chemistry 57 (16), 6989-7005, 2014 | 59 | 2014 |
| Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target JW Choy, C Bryant, CM Calvet, PS Doyle, SS Gunatilleke, SSF Leung, ... Beilstein journal of organic chemistry 9 (1), 15-25, 2013 | 53 | 2013 |
| Trypanosoma cruzi–cardiomyocyte interaction: role of fibronectin in the recognition process and extracellular matrix expression in vitro and in vivo CM Calvet, M Meuser, D Almeida, MNL Meirelles, MCS Pereira Experimental parasitology 107 (1-2), 20-30, 2004 | 53 | 2004 |
| Efficacy of 2-hydroxy-3-phenylsulfanylmethyl-[1, 4]-naphthoquinone derivatives against different Trypanosoma cruzi discrete type units: Identification of a promising hit compound LS Lara, CS Moreira, CM Calvet, GC Lechuga, RS Souza, ... European Journal of Medicinal Chemistry 144, 572-581, 2018 | 47 | 2018 |
| Hydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease DR de Menezes, CM Calvet, GC Rodrigues, MC de Souza Pereira, ... Journal of Enzyme Inhibition and Medicinal Chemistry 31 (6), 964-973, 2016 | 40 | 2016 |
| Binding Mode and Potency of N-Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51 DF Vieira, JY Choi, CM Calvet, JL Siqueira-Neto, JB Johnston, D Kellar, ... Journal of medicinal chemistry 57 (23), 10162-10175, 2014 | 39 | 2014 |
| Heparan Sulfate Proteoglycans Mediate the Invasion of Cardiomyocytes by Trypanosoma cruzi CM Calvet, L Toma, FR De Souza, MDENSL DE MEIRELLES, ... Journal of Eukaryotic Microbiology 50 (2), 97-103, 2003 | 39 | 2003 |
| Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole Derivatives as Antiprotozoal Agents F Saccoliti, VN Madia, V Tudino, A De Leo, L Pescatori, A Messore, ... Journal of Medicinal Chemistry 62 (3), 1330-1347, 2019 | 36 | 2019 |
| Current understanding of the Trypanosoma cruzi-cardiomyocyte interaction CM Calvet, TG Melo, LR Garzoni, FOR Oliveira Jr, DTS Neto, M NSL, ... Frontiers in immunology 3, 327, 2012 | 34 | 2012 |
| Rapid chagas disease drug target discovery using directed evolution in drug-sensitive yeast S Ottilie, GM Goldgof, CM Calvet, GK Jennings, G LaMonte, J Schenken, ... ACS chemical biology 12 (2), 422-434, 2017 | 33 | 2017 |
| Involvement of host cell heparan sulfate proteoglycan in Trypanosoma cruzi amastigote attachment and invasion R Bambino-Medeiros, CM Calvet, D Vicente, L Toma, MA Krieger, ... Parasitology 138 (5), 593-601, 2011 | 33 | 2011 |
| Self-masked aldehyde inhibitors: a novel strategy for inhibiting cysteine proteases L Li, BC Chenna, KS Yang, TR Cole, ZT Goodall, M Giardini, ... Journal of medicinal chemistry 64 (15), 11267-11287, 2021 | 30 | 2021 |
| Trypanosoma cruzi heparin-binding proteins mediate the adherence of epimastigotes to the midgut epithelial cells of Rhodnius prolixus CR Alves, F Souza-Silva, CM Calvet, LMC Côrtes, MS Gonzalez, L Toma, ... Parasitology 139 (6), 735-743, 2012 | 30 | 2012 |
| Trypanosoma cruzi heparin-binding proteins and the nature of the host cell heparan sulfate-binding domain FOR de Oliveira Jr, CR Alves, CM Calvet, L Toma, RI Bouças, HB Nader, ... Microbial pathogenesis 44 (4), 329-338, 2008 | 30 | 2008 |
| 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi … CM Calvet, JY Choi, D Thomas, B Suzuki, K Hirata, S Lostracco-Johnson, ... PLoS neglected tropical diseases 11 (12), e0006132, 2017 | 29 | 2017 |