| Structures of Cas9 endonucleases reveal RNA-mediated conformational activation M Jinek, F Jiang, DW Taylor, SH Sternberg, E Kaya, E Ma, C Anders, ... Science 343 (6176), 1247997, 2014 | 1648 | 2014 |
| A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity D Cifuentes, H Xue, DW Taylor, H Patnode, Y Mishima, S Cheloufi, E Ma, ... Science 328 (5986), 1694-1698, 2010 | 1067 | 2010 |
| Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage F Jiang, DW Taylor, JS Chen, JE Kornfeld, K Zhou, AJ Thompson, ... Science 351 (6275), 867-871, 2016 | 736 | 2016 |
| Rational design of a split-Cas9 enzyme complex AV Wright, SH Sternberg, DW Taylor, BT Staahl, JA Bardales, JE Kornfeld, ... Proceedings of the National Academy of Sciences 112 (10), 2984-2989, 2015 | 389 | 2015 |
| RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus RHJ Staals, Y Zhu, DW Taylor, JE Kornfeld, K Sharma, A Barendregt, ... Molecular cell 56 (4), 518-530, 2014 | 366 | 2014 |
| Structural insights into RNA processing by the human RISC-loading complex HW Wang, C Noland, B Siridechadilok, DW Taylor, E Ma, K Felderer, ... Nature structural & molecular biology 16 (11), 1148-1153, 2009 | 342 | 2009 |
| Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus RHJ Staals, Y Agari, S Maki-Yonekura, Y Zhu, DW Taylor, E Van Duijn, ... Molecular cell 52 (1), 135-145, 2013 | 296 | 2013 |
| CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference ML Hochstrasser, DW Taylor, P Bhat, CK Guegler, SH Sternberg, ... Proceedings of the National Academy of Sciences 111 (18), 6618-6623, 2014 | 274 | 2014 |
| Structural basis for mismatch surveillance by CRISPR–Cas9 JPK Bravo, MS Liu, GN Hibshman, TL Dangerfield, K Jung, RS McCool, ... Nature 603 (7900), 343-347, 2022 | 213 | 2022 |
| DNA unwinding is the primary determinant of CRISPR-Cas9 activity S Gong, HH Yu, KA Johnson, DW Taylor Cell reports 22 (2), 359-371, 2018 | 207 | 2018 |
| Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning DW Taylor, Y Zhu, RHJ Staals, JE Kornfeld, A Shinkai, J van der Oost, ... Science 348 (6234), 581-585, 2015 | 174 | 2015 |
| Substrate-specific structural rearrangements of human Dicer DW Taylor, E Ma, H Shigematsu, MA Cianfrocco, CL Noland, ... Nature structural & molecular biology 20 (6), 662-670, 2013 | 140 | 2013 |
| Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication JPK Bravo, TL Dangerfield, DW Taylor, KA Johnson Molecular cell 81 (7), 1548-1552. e4, 2021 | 130 | 2021 |
| Cas4-dependent prespacer processing ensures high-fidelity programming of CRISPR arrays H Lee, Y Zhou, DW Taylor, DG Sashital Molecular cell 70 (1), 48-59. e5, 2018 | 114 | 2018 |
| An RNA degradation machine sculpted by Ro autoantigen and noncoding RNA X Chen, DW Taylor, CC Fowler, JE Galan, HW Wang, SL Wolin Cell 153 (1), 166-177, 2013 | 109 | 2013 |
| DNA targeting by a minimal CRISPR RNA-guided cascade ML Hochstrasser, DW Taylor, JE Kornfeld, E Nogales, JA Doudna Molecular cell 63 (5), 840-851, 2016 | 107 | 2016 |
| Engineered CRISPR/Cas9 enzymes improve discrimination by slowing DNA cleavage to allow release of off-target DNA MS Liu, S Gong, HH Yu, K Jung, KA Johnson, DW Taylor Nature Communications 11 (1), 3576, 2020 | 100 | 2020 |
| Supercharging enables organized assembly of synthetic biomolecules AJ Simon, Y Zhou, V Ramasubramani, J Glaser, A Pothukuchy, J Gollihar, ... Nature chemistry 11 (3), 204-212, 2019 | 86 | 2019 |
| Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle GS Hansman, DW Taylor, JS McLellan, TJ Smith, I Georgiev, JRH Tame, ... Journal of virology 86 (7), 3635-3646, 2012 | 86 | 2012 |
| SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation JA Steens, Y Zhu, DW Taylor, JPK Bravo, SHP Prinsen, CD Schoen, ... Nature communications 12 (1), 5033, 2021 | 78 | 2021 |
Jennifer DoudnaProfessor of Molecular and Cell Biology and Chemistry, UC BerkeleyOverená e-mailová adresa na: berkeley.edu