Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation X Hou, IR Outhwaite, L Pedi, SB Long Elife 9, e62772, 2020 | 57 | 2020 |
Discovery and molecular basis of subtype-selective cyclophilin inhibitors AA Peterson, AM Rangwala, MK Thakur, PS Ward, C Hung, IR Outhwaite, ... Nature Chemical Biology 18 (11), 1184-1195, 2022 | 26 | 2022 |
Allosteric regulation and inhibition of protein kinases VR Mingione, YT Paung, IR Outhwaite, MA Seeliger Biochemical Society Transactions 51 (1), 373-385, 2023 | 14 | 2023 |
Motivation to Impact: Medical Student Volunteerism in the COVID 19 Pandemic. HE Phillips, RB Jennings, IR Outhwaite, S Grosser, M Chandra, V Ende, ... Medical Science Educator, 2022 | 13 | 2022 |
Lucanthone, a potential PPT1 inhibitor, perturbs stemness, reduces tumor microtube formation, and slows the growth of temozolomide-resistant gliomas in vivo DP Radin, S Shifman, IR Outhwaite, A Sharma, R Bases, MA Seeliger, ... The Journal of Pharmacology and Experimental Therapeutics 389 (1), 51-60, 2024 | 4 | 2024 |
Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting IR Outhwaite, S Singh, BT Berger, S Knapp, JD Chodera, MA Seeliger Elife 12, e86189, 2023 | 3 | 2023 |
Probing conformational dynamics to understand kinase inhibition IR Outhwaite, MA Seeliger Elife 12, e92753, 2023 | 3 | 2023 |
Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib A Leyte-Vidal, RA DeFilippis, IR Outhwaite, I Kwan, JY Lee, C Leavitt, ... Leukemia 38 (9), 2046-2050, 2024 | 2 | 2024 |
Death by a thousand cuts–combining kinase inhibitors for selective target inhibition and rational polypharmacology IR Outhwaite, S Singh, BT Berger, S Knapp, JD Chodera, MA Seeliger bioRxiv, 2023.01. 13.523972, 2023 | 1 | 2023 |
The Effects of the Physical and Professional Workplace Environments on the Well-Being of Nursing Staff R Jennings, I Outhwaite, I Granek, F Haq AJN The American Journal of Nursing 125 (3), 30-39, 2025 | | 2025 |
Resistance to Allosteric Inhibitors I Outhwaite, I Kwan, NP Shah, I Bahar, MA Seeliger Available at SSRN 5135932, 0 | | |
Cryo-EM structure of the calcium release-activated calcium channel X Hou, IR Outhwaite, L Pedi, SB Long | | |