| Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3 X Mao, MT Ou, SS Karuppagounder, TI Kam, X Yin, Y Xiong, P Ge, ... Science 353 (6307), aah3374, 2016 | 749 | 2016 |
| Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson’s disease I Martin, JW Kim, BD Lee, HC Kang, JC Xu, H Jia, J Stankowski, MS Kim, ... Cell 157 (2), 472-485, 2014 | 312 | 2014 |
| GTPase activity plays a key role in the pathobiology of LRRK2 Y Xiong, CE Coombes, A Kilaru, X Li, AD Gitler, WJ Bowers, VL Dawson, ... PLoS genetics 6 (4), e1000902, 2010 | 237 | 2010 |
| Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily K Stafa, E Tsika, R Moser, A Musso, L Glauser, A Jones, S Biskup, ... Human molecular genetics 23 (8), 2055-2077, 2014 | 158 | 2014 |
| ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2 Y Xiong, C Yuan, R Chen, TM Dawson, VL Dawson Journal of Neuroscience 32 (11), 3877-3886, 2012 | 123 | 2012 |
| The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior J Zhang, Y Wang, Z Chi, MJ Keuss, YME Pai, HC Kang, J Shin, ... Cell 145 (2), 284-299, 2011 | 114 | 2011 |
| Modeling Parkinson’s Disease in Drosophila: What Have We Learned for Dominant Traits? Y Xiong, J Yu Frontiers in Neurology 9, 228, 2018 | 99 | 2018 |
| LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization R Migheli, MG Del Giudice, Y Spissu, G Sanna, Y Xiong, TM Dawson, ... PloS one 8 (10), e77198, 2013 | 99 | 2013 |
| Robust kinase-and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice Y Xiong, S Neifert, SS Karuppagounder, Q Liu, JN Stankowski, BD Lee, ... Proceedings of the National Academy of Sciences 115 (7), 1635-1640, 2018 | 91 | 2018 |
| PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency SK Pirooznia, C Yuan, MR Khan, SS Karuppagounder, L Wang, Y Xiong, ... Molecular neurodegeneration 15, 1-21, 2020 | 86 | 2020 |
| Models of LRRK2-associated Parkinson’s disease Y Xiong, TM Dawson, VL Dawson Leucine-Rich Repeat Kinase 2 (LRRK2), 163-191, 2017 | 84 | 2017 |
| Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2 X Li, DJ Moore, Y Xiong, TM Dawson, VL Dawson Journal of Biological Chemistry 285 (38), 29569-29576, 2010 | 75 | 2010 |
| LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-mediated neurotoxicity SS Karuppagounder, Y Xiong, Y Lee, MC Lawless, D Kim, E Nordquist, ... Journal of chemical neuroanatomy 76, 90-97, 2016 | 53 | 2016 |
| Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity EV Nikonova, Y Xiong, KQ Tanis, VL Dawson, RL Vogel, EM Finney, ... Human molecular genetics 21 (1), 163-174, 2012 | 49 | 2012 |
| Complement and coagulation cascades are potentially involved in dopaminergic neurodegeneration in α-synuclein-based mouse models of Parkinson’s disease SX Ma, BA Seo, D Kim, Y Xiong, SH Kwon, S Brahmachari, S Kim, TI Kam, ... Journal of proteome research 20 (7), 3428-3443, 2021 | 41 | 2021 |
| LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease Y Xiong, VL Dawson, TM Dawson Biochemical Society Transactions 40 (5), 1074-1079, 2012 | 40 | 2012 |
| IQGAP and mitotic exit network (MEN) proteins are required for cytokinesis and re-polarization of the actin cytoskeleton in the budding yeast, Saccharomyces cerevisiae M Corbett, Y Xiong, JR Boyne, DJ Wright, E Munro, C Price European journal of cell biology 85 (11), 1201-1215, 2006 | 37 | 2006 |
| Overexpression of Parkinson’s disease-associated mutation LRRK2 G2019S in mouse forebrain induces behavioral deficits and α-synuclein pathology Y Xiong, S Neifert, SS Karuppagounder, JN Stankowski, BD Lee, ... Eneuro 4 (2), 2017 | 35 | 2017 |
| Headcase and unkempt regulate tissue growth and cell cycle progression in response to nutrient restriction N Li, Q Liu, Y Xiong, J Yu Cell reports 26 (3), 733-747. e3, 2019 | 20 | 2019 |
| Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration Q Liu, J Bautista-Gomez, DA Higgins, J Yu, Y Xiong Science signaling 14 (693), eabg3555, 2021 | 19 | 2021 |