Directed evolution of CRISPR-Cas9 to increase its specificity JK Lee, E Jeong, J Lee, M Jung, E Shin, Y Kim, K Lee, I Jung, D Kim, ... Nature communications 9 (1), 3048, 2018 | 531 | 2018 |
Measuring and reducing off-target activities of programmable nucleases including CRISPR-Cas9 T Koo, J Lee, JS Kim Molecules and cells 38 (6), 475-481, 2015 | 251 | 2015 |
Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulation FG Glansdorp, GL Thomas, JK Lee, JM Dutton, GPC Salmond, M Welch, ... Organic & biomolecular chemistry 2 (22), 3329-3336, 2004 | 115 | 2004 |
Combining SELEX Screening and Rational Design to Develop Light-Up Fluorophore− RNA Aptamer Pairs for RNA Tagging J Lee, KH Lee, J Jeon, A Dragulescu-Andrasi, F Xiao, J Rao ACS chemical biology 5 (11), 1065-1074, 2010 | 47 | 2010 |
Functional identification of ligands for a catalytic metal ion in group I introns M Forconi, J Lee, JK Lee, JA Piccirilli, D Herschlag Biochemistry 47 (26), 6883-6894, 2008 | 46 | 2008 |
Single molecule analysis of effects of non-canonical guide RNAs and specificity-enhancing mutations on Cas9-induced DNA unwinding IC Okafor, D Singh, Y Wang, M Jung, H Wang, J Mallon, S Bailey, JK Lee, ... Nucleic acids research 47 (22), 11880-11888, 2019 | 41 | 2019 |
Sniper2L is a high-fidelity Cas9 variant with high activity Y Kim, N Kim, I Okafor, S Choi, S Min, J Lee, SM Bae, K Choi, J Choi, ... Nature chemical biology 19 (8), 972-980, 2023 | 28 | 2023 |
Using Sniper-Cas9 to minimize off-target effects of CRISPR-Cas9 without the loss of on-target activity via directed evolution J Lee, M Jung, E Jeong, JK Lee Journal of Visualized Experiments (JoVE), e59202, 2019 | 24 | 2019 |
TAPE-seq is a cell-based method for predicting genome-wide off-target effects of prime editor J Kwon, M Kim, S Bae, A Jo, Y Kim, JK Lee Nature Communications 13 (1), 7975, 2022 | 19 | 2022 |
Extru-seq: a method for predicting genome-wide Cas9 off-target sites with advantages of both cell-based and in vitro approaches J Kwon, M Kim, W Hwang, A Jo, GH Hwang, M Jung, UG Kim, G Cui, ... Genome biology 24 (1), 4, 2023 | 9 | 2023 |
Assessing the predictive ability of computational epitope prediction methods on Fel d 1 and other allergens H Kwon, S Ko, K Ha, JK Lee, Y Choi Plos one 19 (8), e0306254, 2024 | 1 | 2024 |
Highly efficient CRISPR-mediated genome editing through microfluidic droplet cell mechanoporation YJ Kim, D Yun, JK Lee, C Jung, AJ Chung Nature communications 15 (1), 8099, 2024 | | 2024 |