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| Identification of stem cells in small intestine and colon by marker gene Lgr5 N Barker, JH Van Es, J Kuipers, P Kujala, M Van Den Born, M Cozijnsen, ... Nature 449 (7165), 1003-1007, 2007 | 6558 | 2007 |
| Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium T Sato, DE Stange, M Ferrante, RGJ Vries, JH Van Es, S Van Den Brink, ... Gastroenterology 141 (5), 1762-1772, 2011 | 3891 | 2011 |
| Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ... Nature 469 (7330), 415-418, 2011 | 2890 | 2011 |
| Crypt stem cells as the cells-of-origin of intestinal cancer N Barker, RA Ridgway, JH Van Es, M Van De Wetering, H Begthel, ... Nature 457 (7229), 608-611, 2009 | 2547 | 2009 |
| Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells HJ Snippert, LG Van Der Flier, T Sato, JH Van Es, M Van Den Born, ... Cell 143 (1), 134-144, 2010 | 2122 | 2010 |
| Caught up in a Wnt storm: Wnt signaling in cancer RH Giles, JH Van Es, H Clevers Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1653 (1), 1-24, 2003 | 2067 | 2003 |
| Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells JH van Es, ME Van Gijn, O Riccio, M Van Den Born, M Vooijs, H Begthel, ... Nature 435 (7044), 959-963, 2005 | 1886 | 2005 |
| Lgr5+ ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro N Barker, M Huch, P Kujala, M van de Wetering, HJ Snippert, JH van Es, ... Cell stem cell 6 (1), 25-36, 2010 | 1827 | 2010 |
| In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration M Huch, C Dorrell, SF Boj, JH Van Es, VSW Li, M Van De Wetering, ... Nature 494 (7436), 247-250, 2013 | 1712 | 2013 |
| Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF M Van de Wetering, R Cavallo, D Dooijes, M van Beest, J van Es, ... Cell 88 (6), 789-799, 1997 | 1524 | 1997 |
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| Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas AG Schepers, HJ Snippert, DE Stange, M van den Born, JH van Es, ... Science 337 (6095), 730-735, 2012 | 1286 | 2012 |
| Lgr5 marks cycling, yet long-lived, hair follicle stem cells V Jaks, N Barker, M Kasper, JH Van Es, HJ Snippert, H Clevers, ... Nature genetics 40 (11), 1291-1299, 2008 | 1147 | 2008 |
| Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors BK Koo, M Spit, I Jordens, TY Low, DE Stange, M Van De Wetering, ... Nature 488 (7413), 665-669, 2012 | 1048 | 2012 |
| De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine APG Haramis, H Begthel, M Van Den Born, J Van Es, S Jonkheer, ... Science 303 (5664), 1684-1686, 2004 | 978 | 2004 |
| Mutations in the APC tumour suppressor gene cause chromosomal instability R Fodde, J Kuipers, C Rosenberg, R Smits, M Kielman, C Gaspar, ... Nature cell biology 3 (4), 433-438, 2001 | 967 | 2001 |
| Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin HJ Snippert, A Haegebarth, M Kasper, V Jaks, JH van Es, N Barker, ... Science 327 (5971), 1385-1389, 2010 | 912 | 2010 |
| Dll1+ secretory progenitor cells revert to stem cells upon crypt damage JH Van Es, T Sato, M Van De Wetering, A Lyubimova, AN Yee Nee, ... Nature cell biology 14 (10), 1099-1104, 2012 | 872 | 2012 |
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