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Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA L Zhang, X Lu, J Lu, H Liang, Q Dai, GL Xu, C Luo, H Jiang, C He Nature chemical biology 8 (4), 328-330, 2012 | 367 | 2012 |
Structural insight into substrate preference for TET-mediated oxidation L Hu, J Lu, J Cheng, Q Rao, Z Li, H Hou, Z Lou, L Zhang, W Li, W Gong, ... Nature 527 (7576), 118-122, 2015 | 307 | 2015 |
Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer Y Shen, X Wang, J Lu, M Salfenmoser, NM Wirsik, N Schleussner, A Imle, ... Cancer cell 37 (6), 800-817. e7, 2020 | 263 | 2020 |
Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation J Wang, C Luo, C Shan, Q You, J Lu, S Elf, Y Zhou, Y Wen, JL Vinkenborg, ... Nature chemistry 7 (12), 968-979, 2015 | 255 | 2015 |
Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory NC Hait, LE Wise, JC Allegood, M O'brien, D Avni, TM Reeves, PE Knapp, ... Nature neuroscience 17 (7), 971-980, 2014 | 236 | 2014 |
Drug-perturbation-based stratification of blood cancer S Dietrich, M Oleś, J Lu, L Sellner, S Anders, B Velten, B Wu, J Hüllein, ... The Journal of clinical investigation 128 (1), 427-445, 2018 | 162 | 2018 |
Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2 X Kong, L Chen, L Jiao, X Jiang, F Lian, J Lu, K Zhu, D Du, J Liu, H Ding, ... Journal of medicinal chemistry 57 (22), 9512-9521, 2014 | 122 | 2014 |
IGLV3-21R110 identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics F Nadeu, R Royo, G Clot, M Duran-Ferrer, A Navarro, S Martín, J Lu, ... Blood, The Journal of the American Society of Hematology 137 (21), 2935-2946, 2021 | 80 | 2021 |
The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome M Duran-Ferrer, G Clot, F Nadeu, R Beekman, T Baumann, J Nordlund, ... Nature Cancer 1 (11), 1066-1081, 2020 | 69 | 2020 |
Discovery and optimization of novel, selective histone methyltransferase SET7 inhibitors by pharmacophore-and docking-based virtual screening F Meng, S Cheng, H Ding, S Liu, Y Liu, K Zhu, S Chen, J Lu, Y Xie, L Li, ... Journal of Medicinal Chemistry 58 (20), 8166-8181, 2015 | 64 | 2015 |
Inhibition of autophagy by a small molecule through covalent modification of the LC3 protein S Fan, L Yue, W Wan, Y Zhang, B Zhang, C Otomo, Q Li, T Lin, J Hu, P Xu, ... Angewandte Chemie International Edition 60 (50), 26105-26114, 2021 | 61 | 2021 |
Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets J Lu, H Zeng, Z Liang, L Chen, L Zhang, H Zhang, H Liu, H Jiang, B Shen, ... Scientific reports 5 (1), 14739, 2015 | 60 | 2015 |
Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease F Ye, J Zhang, H Liu, R Hilgenfeld, R Zhang, X Kong, L Li, J Lu, X Zhang, ... Journal of Biological Chemistry 288 (24), 17643-17653, 2013 | 60 | 2013 |
Catalytic mechanism investigation of lysine-specific demethylase 1 (LSD1): a computational study X Kong, S Ouyang, Z Liang, J Lu, L Chen, B Shen, D Li, M Zheng, KK Li, ... PLoS One 6 (9), e25444, 2011 | 60 | 2011 |
FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels L Chen, LF Luo, J Lu, L Li, YF Liu, J Wang, H Liu, H Song, H Jiang, ... PLoS One 9 (7), e103033, 2014 | 58 | 2014 |
Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia J Lu, E Cannizzaro, F Meier-Abt, S Scheinost, PM Bruch, HAR Giles, ... Nature cancer 2 (8), 853-864, 2021 | 57 | 2021 |
Inhibition of eukaryotic translation by the antitumor natural product agelastatin A B McClary, B Zinshteyn, M Meyer, M Jouanneau, S Pellegrino, ... Cell chemical biology 24 (5), 605-613. e5, 2017 | 51 | 2017 |
Catalytic mechanism of histone acetyltransferase p300: from the proton transfer to acetylation reaction X Zhang, S Ouyang, X Kong, Z Liang, J Lu, K Zhu, D Zhao, M Zheng, ... The journal of physical chemistry B 118 (8), 2009-2019, 2014 | 48 | 2014 |
A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-β-lactamase-1 K Zhu, J Lu, Z Liang, X Kong, F Ye, L Jin, H Geng, Y Chen, M Zheng, ... Journal of computer-aided molecular design 27, 247-256, 2013 | 46 | 2013 |