Spremljaj
Junyan Lu
Junyan Lu
University Hospital Heidelberg
Preverjeni e-poštni naslov na uni-heidelberg.de
Naslov
Navedeno
Navedeno
Leto
Computational drug discovery
S Ou-Yang, J Lu, X Kong, Z Liang, C Luo, H Jiang
Acta Pharmacologica Sinica 33 (9), 1131-1140, 2012
4342012
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
L Zhang, X Lu, J Lu, H Liang, Q Dai, GL Xu, C Luo, H Jiang, C He
Nature chemical biology 8 (4), 328-330, 2012
3672012
Structural insight into substrate preference for TET-mediated oxidation
L Hu, J Lu, J Cheng, Q Rao, Z Li, H Hou, Z Lou, L Zhang, W Li, W Gong, ...
Nature 527 (7576), 118-122, 2015
3072015
Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer
Y Shen, X Wang, J Lu, M Salfenmoser, NM Wirsik, N Schleussner, A Imle, ...
Cancer cell 37 (6), 800-817. e7, 2020
2632020
Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation
J Wang, C Luo, C Shan, Q You, J Lu, S Elf, Y Zhou, Y Wen, JL Vinkenborg, ...
Nature chemistry 7 (12), 968-979, 2015
2552015
Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory
NC Hait, LE Wise, JC Allegood, M O'brien, D Avni, TM Reeves, PE Knapp, ...
Nature neuroscience 17 (7), 971-980, 2014
2362014
Drug-perturbation-based stratification of blood cancer
S Dietrich, M Oleś, J Lu, L Sellner, S Anders, B Velten, B Wu, J Hüllein, ...
The Journal of clinical investigation 128 (1), 427-445, 2018
1622018
Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2
X Kong, L Chen, L Jiao, X Jiang, F Lian, J Lu, K Zhu, D Du, J Liu, H Ding, ...
Journal of medicinal chemistry 57 (22), 9512-9521, 2014
1222014
IGLV3-21R110 identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics
F Nadeu, R Royo, G Clot, M Duran-Ferrer, A Navarro, S Martín, J Lu, ...
Blood, The Journal of the American Society of Hematology 137 (21), 2935-2946, 2021
802021
The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome
M Duran-Ferrer, G Clot, F Nadeu, R Beekman, T Baumann, J Nordlund, ...
Nature Cancer 1 (11), 1066-1081, 2020
692020
Discovery and optimization of novel, selective histone methyltransferase SET7 inhibitors by pharmacophore-and docking-based virtual screening
F Meng, S Cheng, H Ding, S Liu, Y Liu, K Zhu, S Chen, J Lu, Y Xie, L Li, ...
Journal of Medicinal Chemistry 58 (20), 8166-8181, 2015
642015
Inhibition of autophagy by a small molecule through covalent modification of the LC3 protein
S Fan, L Yue, W Wan, Y Zhang, B Zhang, C Otomo, Q Li, T Lin, J Hu, P Xu, ...
Angewandte Chemie International Edition 60 (50), 26105-26114, 2021
612021
Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets
J Lu, H Zeng, Z Liang, L Chen, L Zhang, H Zhang, H Liu, H Jiang, B Shen, ...
Scientific reports 5 (1), 14739, 2015
602015
Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease
F Ye, J Zhang, H Liu, R Hilgenfeld, R Zhang, X Kong, L Li, J Lu, X Zhang, ...
Journal of Biological Chemistry 288 (24), 17643-17653, 2013
602013
Catalytic mechanism investigation of lysine-specific demethylase 1 (LSD1): a computational study
X Kong, S Ouyang, Z Liang, J Lu, L Chen, B Shen, D Li, M Zheng, KK Li, ...
PLoS One 6 (9), e25444, 2011
602011
FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels
L Chen, LF Luo, J Lu, L Li, YF Liu, J Wang, H Liu, H Song, H Jiang, ...
PLoS One 9 (7), e103033, 2014
582014
Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia
J Lu, E Cannizzaro, F Meier-Abt, S Scheinost, PM Bruch, HAR Giles, ...
Nature cancer 2 (8), 853-864, 2021
572021
Inhibition of eukaryotic translation by the antitumor natural product agelastatin A
B McClary, B Zinshteyn, M Meyer, M Jouanneau, S Pellegrino, ...
Cell chemical biology 24 (5), 605-613. e5, 2017
512017
Catalytic mechanism of histone acetyltransferase p300: from the proton transfer to acetylation reaction
X Zhang, S Ouyang, X Kong, Z Liang, J Lu, K Zhu, D Zhao, M Zheng, ...
The journal of physical chemistry B 118 (8), 2009-2019, 2014
482014
A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-β-lactamase-1
K Zhu, J Lu, Z Liang, X Kong, F Ye, L Jin, H Geng, Y Chen, M Zheng, ...
Journal of computer-aided molecular design 27, 247-256, 2013
462013
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