| H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis AS Harutyunyan, B Krug, H Chen, S Papillon-Cavanagh, M Zeinieh, ... Nature communications 10 (1), 1262, 2019 | 318 | 2019 |
| Stalled developmental programs at the root of pediatric brain tumors S Jessa, A Blanchet-Cohen, B Krug, M Vladoiu, M Coutelier, D Faury, ... Nature genetics 51 (12), 1702-1713, 2019 | 249 | 2019 |
| Pervasive H3K27 acetylation leads to ERV expression and a therapeutic vulnerability in H3K27M gliomas B Krug, N De Jay, AS Harutyunyan, S Deshmukh, DM Marchione, ... Cancer cell 35 (5), 782-797. e8, 2019 | 196 | 2019 |
| K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas S Jessa, A Mohammadnia, AS Harutyunyan, M Hulswit, S Varadharajan, ... Nature genetics 54 (12), 1865-1880, 2022 | 73 | 2022 |
| H3K27M in gliomas causes a one-step decrease in H3K27 methylation and reduced spreading within the constraints of H3K36 methylation AS Harutyunyan, H Chen, T Lu, C Horth, H Nikbakht, B Krug, C Russo, ... Cell reports 33 (7), 2020 | 70 | 2020 |
| Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome BJ Golbourn, ME Halbert, K Halligan, S Varadharajan, B Krug, NE Mbah, ... Nature cancer 3 (5), 629-648, 2022 | 47 | 2022 |
| Oncohistones: a roadmap to stalled development S Deshmukh, A Ptack, B Krug, N Jabado The FEBS journal 289 (5), 1315-1328, 2022 | 37 | 2022 |
| Histone H3. 3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks A Chaouch, J Berlandi, CCL Chen, F Frey, S Badini, AS Harutyunyan, ... Molecular cell 81 (23), 4876-4890. e7, 2021 | 32 | 2021 |
| Polycomb repressive complex 2 in the driver’s seat of childhood and young adult brain tumours B Krug, AS Harutyunyan, S Deshmukh, N Jabado Trends in cell biology 31 (10), 814-828, 2021 | 27 | 2021 |
| Pediatric glioma histone H3. 3 K27M/G34R mutations drive abnormalities in PML nuclear bodies HPJ Voon, L Hii, A Garvie, M Udugama, B Krug, C Russo, AC Chüeh, ... Genome Biology 24 (1), 284, 2023 | 12 | 2023 |
| H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis. Nat Commun 10: 1–13 AS Harutyunyan, B Krug, H Chen, S Papillon-Cavanagh, M Zeinieh, ... Epub 2019/03/21. doi: 10.1038/s41467-019-09140-x. PubMed PMID: 30890717, 2019 | 11 | 2019 |
| H3K27M in gliomas causes a one-step decrease in H3K27 methylation and reduced spreading within the constraints of H3K36 methylation. Cell Rep 33: 108390 AS Harutyunyan, H Chen, T Lu, C Horth, H Nikbakht, B Krug, C Russo, ... | 9 | 2020 |
| Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function AF Andrade, A Annett, E Karimi, DG Topouza, M Rezanejad, Y Liu, ... Nature Communications 15 (1), 7769, 2024 | 2 | 2024 |
| H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs B Krug, B Hu, H Chen, A Ptack, X Chen, KH Gretarsson, S Deshmukh, ... bioRxiv, 2023.11. 28.567931, 2023 | | 2023 |
| TMIC-04. IMMUNE PROFILING OF PEDIATRIC ONCOHISTONE GLIOMAS REVEALS DIVERSE MYELOID POPULATIONS AND TUMOR-PROMOTING BEHAVIORS AF Andrade, D Topouza, M McNicholas, EGG Santiago, A De Cola, ... Neuro-Oncology 25 (Suppl 5), v278, 2023 | | 2023 |
| DIPG-36. H3K27M HISTONE MUTANT GLIOMAS ARE SENSITIVE TO METHIONINE LOSS AND MAT2A INHIBITION THROUGH A NOVEL FEEDBACK MECHANISM BETWEEN AMD1 AND METTL16 A Chilukuri, M Halbert, B Golbourn, S Varadharajan, B Krug, N Mbah, ... Neuro-Oncology 25 (Supplement_1), i21-i21, 2023 | | 2023 |
| TMET-09. LOSS OF MAT2A COMPROMISES METHIONINE METABOLISM AND REPRESENTS A VULNERABILITY IN H3K27M MUTANT GLIOMAS M Halbert, B Golbourn, K Halligan, S Varadharajan, B Krug, N Mbah, ... Neuro-Oncology 24 (Supplement_7), vii263-vii263, 2022 | | 2022 |
| DIPG-06. Uncovering the FACTs in Diffuse Midline Glioma (DMG) H Holliday, A Ehteda, A Khan, B Krug, JRC Rouaen, N Jayatilleke, ... Neuro-Oncology 24 (Suppl 1), i18, 2022 | | 2022 |
| ELUCIDATING THE ROLE OF LONG NON-CODING RNAS IN PEDIATRIC HIGH GRADE GLIOMAS JW Tsai, FPB Dubois, DK Wang, A Crane, AL Condurat, B Krug, A Brown, ... NEURO-ONCOLOGY 24, 68-69, 2022 | | 2022 |
| The role of chromatin remodeling in H3K27M-mutant gliomas B Krug McGill University (Canada), 2022 | | 2022 |
