Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants RT Walton, KA Christie, MN Whittaker, BP Kleinstiver Science 368 (6488), 290-296, 2020 | 1074 | 2020 |
Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing BP Kleinstiver, AA Sousa, RT Walton, YE Tak, JY Hsu, K Clement, ... Nature biotechnology 37 (3), 276-282, 2019 | 650 | 2019 |
Discovery of widespread type I and type V CRISPR-Cas inhibitors ND Marino, JY Zhang, AL Borges, AA Sousa, LM Leon, BJ Rauch, ... Science 362 (6411), 240-242, 2018 | 260 | 2018 |
Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program Y Hu, AM Stilp, CP McHugh, S Rao, D Jain, X Zheng, J Lane, ... The American Journal of Human Genetics 108 (5), 874-893, 2021 | 54 | 2021 |
Precise DNA cleavage using CRISPR-SpRYgests KA Christie, JA Guo, RA Silverstein, RM Doll, M Mabuchi, HE Stutzman, ... Nature biotechnology 41 (3), 409-416, 2023 | 42 | 2023 |
Scalable characterization of the PAM requirements of CRISPR–Cas enzymes using HT-PAMDA RT Walton, JY Hsu, JK Joung, BP Kleinstiver Nature protocols 16 (3), 1511-1547, 2021 | 36 | 2021 |
Pooled genetic screens with image‐based profiling RT Walton, A Singh, PC Blainey Molecular Systems Biology 18 (11), e10768, 2022 | 16 | 2022 |
CROPseq-multi: a versatile solution for multiplexed perturbation and decoding in pooled CRISPR screens RT Walton, Y Qin, PC Blainey bioRxiv, 2024 | 6 | 2024 |
Unconstrained Genome Targeting with near-PAMless Engineered CRISPR-Cas9 Variants B Kleinstiver, RT Walton US Patent App. 17/157,708, 2021 | 1 | 2021 |
Crispr-cas enzymes with enhanced on-target activity B Kleinstiver, RT Walton US Patent App. 17/157,805, 2021 | 1 | 2021 |
Methods to characterize enzymes for genome engineering B Kleinstiver, RT Walton US Patent App. 17/794,520, 2023 | | 2023 |
Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing (vol 37, pg 276, 2019) BP Kleinstiver, AA Sousa, RT Walton, YE Tak, JY Hsu, K Clement, ... NATURE BIOTECHNOLOGY 38 (7), 901-901, 2020 | | 2020 |
Unconstrained Genome Targeting with Engineered Near-PAMless CRISPR-Cas Variants KA Christie, RT Walton, BP Kleinstiver MOLECULAR THERAPY 28 (4), 37-38, 2020 | | 2020 |