| CRISPR activation and interference screens decode stimulation responses in primary human T cells R Schmidt, Z Steinhart, M Layeghi, JW Freimer, R Bueno, VQ Nguyen, ... Science 375 (6580), eabj4008, 2022 | 211* | 2022 |
| GRHL2-dependent enhancer switching maintains a pluripotent stem cell transcriptional subnetwork after exit from naive pluripotency AF Chen, AJ Liu, R Krishnakumar, JW Freimer, B DeVeale, R Blelloch Cell Stem Cell 23 (2), 226-238. e4, 2018 | 101 | 2018 |
| Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks JW Freimer, O Shaked, S Naqvi, N Sinnott-Armstrong, A Kathiria, ... Nature Genetics 54 (8), 1133-1144, 2022 | 71 | 2022 |
| Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells JW Freimer, TJ Hu, R Blelloch elife 7, e38014, 2018 | 71 | 2018 |
| CRISPR screens decode cancer cell pathways that trigger γδ T cell detection MR Mamedov, S Vedova, JW Freimer, AD Sahu, A Ramesh, MM Arce, ... Nature 621 (7977), 188-195, 2023 | 48 | 2023 |
| Expression of alternative Ago2 isoform associated with loss of microRNA-driven translational repression in mouse oocytes JW Freimer, R Krishnakumar, MS Cook, R Blelloch Current Biology 28 (2), 296-302. e3, 2018 | 29 | 2018 |
| High-throughput, efficient, and unbiased capture of small RNAs from low-input samples for sequencing CD Belair, T Hu, B Chu, JW Freimer, MR Cooperberg, RH Blelloch Scientific reports 9 (1), 2262, 2019 | 21 | 2019 |
| G1/S restriction point coordinates phasic gene expression and cell differentiation B DeVeale, L Liu, R Boileau, J Swindlehurst-Chan, B Marsh, JW Freimer, ... Nature communications 13 (1), 3696, 2022 | 13 | 2022 |
| Tissue engineering of muscle tissue I Conboy, J Freimer, L Weisenstein Elsevier, 2011 | 13* | 2011 |
| Cell–cell adhesions in embryonic stem cells regulate the stability and transcriptional activity of β‐catenin S Bhattacharyya, RD Mote, JW Freimer, M Tiwari, S Bansi Singh, ... FEBS letters 596 (13), 1647-1660, 2022 | 7 | 2022 |
| Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease JS Weinstock, MM Arce, JW Freimer, M Ota, A Marson, A Battle, ... Cell Genomics 4 (11), 2024 | 6 | 2024 |
| Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells CT Mowery, JW Freimer, Z Chen, S Casaní-Galdón, JM Umhoefer, ... Nature Genetics 56 (6), 1156-1167, 2024 | 5 | 2024 |
| Central control of dynamic gene circuits governs T cell rest and activation MM Arce, JM Umhoefer, N Arang, S Kasinathan, JW Freimer, Z Steinhart, ... Nature 637 (8047), 930-939, 2025 | 2 | 2025 |
| Abstract PR008: CD4+ T cell rest and activation is enabled by centralized control of state specific regulatory genes MM Arce, J Umhoefer, N Arang, S Kasinathan, JW Freimer, Z Steinhart, ... Cancer Immunology Research 13 (2_Supplement), PR008-PR008, 2025 | | 2025 |
| Gene targets for manipulating t cell behavior J Freimer, A Marson, J Pritchard, O Shaked US Patent App. 17/754,848, 2024 | | 2024 |
| 334 Computational mapping of CAR-T cell exhaustion through single-cell perturbation screens L Wang, D DeTomaso, A Cass, J Chow, R Bao, AC Boroughs, A Cardozo, ... Journal for ImmunoTherapy of Cancer 12 (Suppl 2), 2024 | | 2024 |
| 282 Improving solid tumor CAR-T therapies by modulating T cell transcriptional states using combinatorial in vitro CRISPR screening followed by in vivo validation LM Leon, AC Boroughs, A Cass, J Choe, A Cardozo, J Chow, ... Journal for ImmunoTherapy of Cancer 12 (Suppl 2), 2024 | | 2024 |
| Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3 JM Umhoefer, MM Arce, S Whalen, R Dajani, L Goudy, S Kasinathan, ... bioRxiv, 2024.08. 30.610436, 2024 | | 2024 |
| A model for accurate quantification of CRISPR effects in pooled FACS screens H Pimentel, JW Freimer, MM Arce, CM Garrido, A Marson, JK Pritchard bioRxiv, 2024 | | 2024 |
| Single-Cell, Pooled CRISPR Screening Reveals T Cell Intrinsic Regulators of Exhaustion in the Context of Chronic Antigen Stimulation GG Wozniak, S Joshi, K Vucci, A Boroughs, A Cardozo, A Cass, B Chen, ... MOLECULAR THERAPY 32 (4), 417-418, 2024 | | 2024 |
Robert BlellochUniversity of California, San FranciscoPreverjeni e-poštni naslov na ucsf.edu