| Targeting the translation machinery in cancer M Bhat, N Robichaud, L Hulea, N Sonenberg, J Pelletier, I Topisirovic Nature reviews Drug discovery 14 (4), 261-278, 2015 | 915 | 2015 |
| mTOR coordinates protein synthesis, mitochondrial activity and proliferation M Morita, SP Gravel, L Hulea, O Larsson, M Pollak, J St-Pierre, ... Cell cycle 14 (4), 473-480, 2015 | 557 | 2015 |
| mTOR as a central regulator of lifespan and aging D Papadopoli, K Boulay, L Kazak, M Pollak, F Mallette, I Topisirovic, ... F1000Research 8, 2019 | 410 | 2019 |
| mTOR controls mitochondrial dynamics and cell survival via MTFP1 M Morita, J Prudent, K Basu, V Goyon, S Katsumura, L Hulea, D Pearl, ... Molecular cell 67 (6), 922-935. e5, 2017 | 340 | 2017 |
| nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs V Gandin, L Masvidal, L Hulea, SP Gravel, M Cargnello, S McLaughlan, ... Genome research 26 (5), 636-648, 2016 | 243 | 2016 |
| The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway M Carbonneau, L M. Gagné, ME Lalonde, MA Germain, A Motorina, ... Nature communications 7 (1), 12700, 2016 | 173 | 2016 |
| METTL13 methylation of eEF1A increases translational output to promote tumorigenesis S Liu, S Hausmann, SM Carlson, ME Fuentes, JW Francis, R Pillai, ... Cell 176 (3), 491-504. e21, 2019 | 156 | 2019 |
| Serine deprivation enhances antineoplastic activity of biguanides SP Gravel, L Hulea, N Toban, E Birman, MJ Blouin, M Zakikhani, Y Zhao, ... Cancer research 74 (24), 7521-7533, 2014 | 145 | 2014 |
| RAS transformation requires CUX1-dependent repair of oxidative DNA damage ZM Ramdzan, C Vadnais, R Pal, G Vandal, C Cadieux, L Leduy, ... PLoS biology 12 (3), e1001807, 2014 | 89 | 2014 |
| CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases L Hulea, A Nepveu Gene 497 (1), 18-26, 2012 | 88 | 2012 |
| Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides L Hulea, SP Gravel, M Morita, M Cargnello, O Uchenunu, YK Im, ... Cell metabolism 28 (6), 817-832. e8, 2018 | 82 | 2018 |
| mTOR-sensitive translation: cleared fog reveals more trees L Masvidal, L Hulea, L Furic, I Topisirovic, O Larsson RNA biology 14 (10), 1299-1305, 2017 | 76 | 2017 |
| Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth BJ Lee, JA Boyer, GL Burnett, AP Thottumkara, N Tibrewal, SL Wilson, ... Nature chemical biology 17 (10), 1065-1074, 2021 | 69 | 2021 |
| Autocrine activation of the Wnt/β-catenin pathway by CUX1 and GLIS1 in breast cancers C Vadnais, P Shooshtarizadeh, CV Rajadurai, R Lesurf, L Hulea, ... Biology open 3 (10), 937-946, 2014 | 49 | 2014 |
| SBI-0640756 attenuates the growth of clinically unresponsive melanomas by disrupting the eIF4F translation initiation complex Y Feng, AB Pinkerton, L Hulea, T Zhang, MA Davies, S Grotegut, Y Cheli, ... Cancer research 75 (24), 5211-5218, 2015 | 46 | 2015 |
| A hydride transfer complex reprograms NAD metabolism and bypasses senescence S Igelmann, F Lessard, O Uchenunu, J Bouchard, A Fernandez-Ruiz, ... Molecular Cell 81 (18), 3848-3865. e19, 2021 | 45 | 2021 |
| Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis M Uriarte, N Sen Nkwe, R Tremblay, O Ahmed, C Messmer, N Mashtalir, ... Nature communications 12 (1), 6984, 2021 | 44 | 2021 |
| PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis S Mzoughi, JY Fong, D Papadopoli, CM Koh, L Hulea, P Pigini, F Di Tullio, ... Nature communications 11 (1), 3520, 2020 | 35 | 2020 |
| Biomedical potential of mTOR modulation by nanoparticles L Hulea, Z Markovic, I Topisirovic, T Simmet, V Trajkovic Trends in biotechnology 34 (5), 349-353, 2016 | 34 | 2016 |
| Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin D Papadopoli, O Uchenunu, R Palia, N Chekkal, L Hulea, I Topisirovic, ... Neoplasia 23 (4), 391-399, 2021 | 33 | 2021 |
