| Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, ... Science 370 (6521), eabe9403, 2020 | 695 | 2020 |
| An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, ... Science 370 (6523), 1473-1479, 2020 | 417 | 2020 |
| Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet LE Buchanan, EB Dunkelberger, HQ Tran, PN Cheng, CC Chiu, P Cao, ... Proceedings of the National Academy of Sciences 110 (48), 19285-19290, 2013 | 299 | 2013 |
| Instantaneous ion configurations in the K+ ion channel selectivity filter revealed by 2D IR spectroscopy HT Kratochvil, JK Carr, K Matulef, AW Annen, H Li, M Maj, J Ostmeyer, ... Science 353 (6303), 1040-1044, 2016 | 221 | 2016 |
| Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking M Schuller, GJ Correy, S Gahbauer, D Fearon, T Wu, RE Díaz, ID Young, ... Science advances 7 (16), eabf8711, 2021 | 157 | 2021 |
| Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2 CJ Bracken, SA Lim, P Solomon, NJ Rettko, DP Nguyen, BS Zha, ... Nature chemical biology 17 (1), 113-121, 2021 | 98 | 2021 |
| Constructing ion channels from water-soluble α-helical barrels AJ Scott, A Niitsu, HT Kratochvil, EJM Lang, JT Sengel, WM Dawson, ... Nature chemistry 13 (7), 643-650, 2021 | 96 | 2021 |
| CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes M Gupta, CM Azumaya, M Moritz, S Pourmal, A Diallo, GE Merz, G Jang, ... Research square, rs. 3. rs-515215, 2021 | 88 | 2021 |
| Designed peptides that assemble into cross-α amyloid-like structures SQ Zhang, H Huang, J Yang, HT Kratochvil, M Lolicato, Y Liu, X Shu, ... Nature Chemical Biology 14 (9), 870-875, 2018 | 74 | 2018 |
| Solvent-independent anharmonicity for carbonyl oscillators SH Schneider, HT Kratochvil, MT Zanni, SG Boxer The Journal of Physical Chemistry B 121 (10), 2331-2338, 2017 | 56 | 2017 |
| An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation M Schoof, B Faust, RA Saunders, S Sangwan, VV Rezelj, N Hoppe, ... | 49 | 2020 |
| Probing the Effects of Gating on the Ion Occupancy of the K+ Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy HT Kratochvil, M Maj, K Matulef, AW Annen, J Ostmeyer, E Perozo, ... Journal of the American Chemical Society 139 (26), 8837-8845, 2017 | 35 | 2017 |
| Transient water wires mediate selective proton transport in designed channel proteins HT Kratochvil, LC Watkins, M Mravic, JL Thomaston, JM Nicoludis, ... Nature chemistry 15 (7), 1012-1021, 2023 | 33 | 2023 |
| Synthesis and application of the blue fluorescent amino acid l-4-cyanotryptophan to assess peptide–membrane interactions K Zhang, IA Ahmed, HT Kratochvil, WF DeGrado, F Gai, H Jo Chemical Communications 55 (35), 5095-5098, 2019 | 29 | 2019 |
| Glutamine Side Chain 13C═18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly H Wu, DJ Saltzberg, HT Kratochvil, H Jo, A Sali, WF DeGrado Journal of the American Chemical Society 141 (18), 7320-7326, 2019 | 16 | 2019 |
| An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, ... BioRxiv, 2020 | 14 | 2020 |
| Consortium QSB, Walter P, Manglik A M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, ... Science 370 (6523), 1473, 2020 | 11 | 2020 |
| Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides HT Kratochvil, RW Newberry, B Mensa, M Mravic, WF DeGrado Faraday discussions 232, 9-48, 2021 | 8 | 2021 |
| De novo-designed transmembrane proteins bind and regulate a cytokine receptor M Mravic, L He, HT Kratochvil, H Hu, SE Nick, W Bai, A Edwards, H Jo, ... Nature Chemical Biology 20 (6), 751-760, 2024 | 5 | 2024 |
| MeMDLM: De Novo Membrane Protein Design with Masked Discrete Diffusion Protein Language Models S Goel, V Thoutam, EM Marroquin, A Gokaslan, A Firouzbakht, S Vincoff, ... arXiv preprint arXiv:2410.16735, 2024 | 2 | 2024 |
