| RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF PI Poulikakos, C Zhang, G Bollag, KM Shokat, N Rosen Nature 464 (7287), 427-430, 2010 | 2066 | 2010 |
| IRE1 signaling affects cell fate during the unfolded protein response JH Lin, H Li, D Yasumura, HR Cohen, C Zhang, B Panning, KM Shokat, ... science 318 (5852), 944-949, 2007 | 1647 | 2007 |
| The unfolded protein response signals through high-order assembly of Ire1 AV Korennykh, PF Egea, AA Korostelev, J Finer-Moore, C Zhang, ... Nature 457 (7230), 687-693, 2009 | 787 | 2009 |
| Structural bioinformatics-based design of selective, irreversible kinase inhibitors MS Cohen, C Zhang, KM Shokat, J Taunton Science 308 (5726), 1318-1321, 2005 | 730 | 2005 |
| The advantages of targeted protein degradation over inhibition: an RTK case study GM Burslem, BE Smith, AC Lai, S Jaime-Figueroa, DC McQuaid, ... Cell chemical biology 25 (1), 67-77. e3, 2018 | 625 | 2018 |
| Single-cell landscape of immunological responses in patients with COVID-19 JY Zhang, XM Wang, X Xing, Z Xu, C Zhang, JW Song, X Fan, P Xia, ... Nature immunology 21 (9), 1107-1118, 2020 | 605 | 2020 |
| Discovery of nitrate–CPK–NLP signalling in central nutrient–growth networks K Liu, Y Niu, M Konishi, Y Wu, H Du, H Sun Chung, L Li, M Boudsocq, ... Nature 545 (7654), 311-316, 2017 | 529 | 2017 |
| Chemical genetic analysis of the time course of signal transduction by JNK JJ Ventura, A Hübner, C Zhang, RA Flavell, KM Shokat, RJ Davis Molecular cell 21 (5), 701-710, 2006 | 426 | 2006 |
| Immunological and inflammatory profiles in mild and severe cases of COVID-19 JW Song, C Zhang, X Fan, FP Meng, Z Xu, P Xia, WJ Cao, T Yang, XP Dai, ... Nature communications 11 (1), 3410, 2020 | 420 | 2020 |
| Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II S Larochelle, R Amat, K Glover-Cutter, M Sansó, C Zhang, JJ Allen, ... Nature structural & molecular biology 19 (11), 1108-1115, 2012 | 408 | 2012 |
| TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II K Glover-Cutter, S Larochelle, B Erickson, C Zhang, K Shokat, RP Fisher, ... Molecular and cellular biology, 2009 | 404 | 2009 |
| Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast B Bodenmiller, S Wanka, C Kraft, J Urban, D Campbell, PG Pedrioli, ... Science signaling 3 (153), rs4-rs4, 2010 | 380 | 2010 |
| Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma S Lourido, J Shuman, C Zhang, KM Shokat, R Hui, LD Sibley Nature 465 (7296), 359-362, 2010 | 375 | 2010 |
| Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2 KR Benjamin, C Zhang, KM Shokat, I Herskowitz Genes & development 17 (12), 1524-1539, 2003 | 356 | 2003 |
| Inhibitor hijacking of Akt activation T Okuzumi, D Fiedler, C Zhang, DC Gray, B Aizenstein, R Hoffman, ... Nature chemical biology 5 (7), 484-493, 2009 | 336 | 2009 |
| An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED W Qi, K Zhao, J Gu, Y Huang, Y Wang, H Zhang, M Zhang, J Zhang, Z Yu, ... Nature chemical biology 13 (4), 381-388, 2017 | 321 | 2017 |
| An unbiased cell morphology–based screen for new, biologically active small molecules M Tanaka, R Bateman, D Rauh, E Vaisberg, S Ramachandani, C Zhang, ... PLoS biology 3 (5), e128, 2005 | 318 | 2005 |
| Bypassing a kinase activity with an ATP-competitive drug FR Papa, C Zhang, K Shokat, P Walter Science 302 (5650), 1533-1537, 2003 | 312 | 2003 |
| Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells ME Burkard, CL Randall, S Larochelle, C Zhang, KM Shokat, RP Fisher, ... Proceedings of the National Academy of Sciences 104 (11), 4383-4388, 2007 | 311 | 2007 |
| Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells S Larochelle, KA Merrick, ME Terret, L Wohlbold, NM Barboza, C Zhang, ... Molecular cell 25 (6), 839-850, 2007 | 288 | 2007 |
