| Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 … T Shimada, H Yamazaki, M Mimura, Y Inui, FP Guengerich The Journal of pharmacology and experimental therapeutics 270 (1), 414-423, 1994 | 3681 | 1994 |
| Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1 T Shimada, CL Hayes, H Yamazaki, S Amin, SS Hecht, FP Guengerich, ... Cancer research 56 (13), 2979-2984, 1996 | 1040 | 1996 |
| Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes H Yamazaki, Y Inui, CH Yun, FP Guengerich, T Shimada Carcinogenesis 13 (10), 1789-1794, 1992 | 507 | 1992 |
| Activation and detoxication of aflatoxin B1 FP Guengerich, WW Johnson, T Shimada, YF Ueng, H Yamazaki, ... Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 402 (1 …, 1998 | 419 | 1998 |
| Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes H Yamazaki, T Shimada Archives of biochemistry and biophysics 346 (1), 161-169, 1997 | 395 | 1997 |
| Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal livers and adult lungs T Shimada, H Yamazaki, M Mimura, N Wakamiya, YF Ueng, ... Drug Metabolism and Disposition 24 (5), 515-522, 1996 | 335 | 1996 |
| Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens. T Shimada, CH Yun, H Yamazaki, JC Gautier, PH Beaune, ... Molecular pharmacology 41 (5), 856-864, 1992 | 322 | 1992 |
| Genomic landscape of esophageal squamous cell carcinoma in a Japanese population G Sawada, A Niida, R Uchi, H Hirata, T Shimamura, Y Suzuki, Y Shiraishi, ... Gastroenterology 150 (5), 1171-1182, 2016 | 313 | 2016 |
| Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes YF Ueng, T Shimada, H Yamazaki, FP Guengerich Chemical research in toxicology 8 (2), 218-225, 1995 | 283 | 1995 |
| Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes H Yamazaki, K Inoue, M Hashimoto, T Shimada Archives of toxicology 73, 65-70, 1999 | 282 | 1999 |
| Roles of NADPH-P450 reductase and apo-and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli H Yamazaki, M Nakamura, T Komatsu, K Ohyama, N Hatanaka, S Asahi, ... Protein expression and purification 24 (3), 329-337, 2002 | 281 | 2002 |
| Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1 T Shimada, H Yamazaki, M Foroozesh, NE Hopkins, WL Alworth, ... Chemical research in toxicology 11 (9), 1048-1056, 1998 | 276 | 1998 |
| Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes H Yamazaki, PM Shaw, FP Guengerich, T Shimada Chemical research in toxicology 11 (6), 659-665, 1998 | 259 | 1998 |
| Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers M Fujieda, H Yamazaki, T Saito, K Kiyotani, MA Gyamfi, M Sakurai, ... Carcinogenesis 25 (12), 2451-2458, 2004 | 254 | 2004 |
| Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4: characterization of a reconstituted cytochrome P450 3A4/NADPH … H Yamazaki, WW Johnson, YF Ueng, T Shimada, FP Guengerich Journal of Biological Chemistry 271 (44), 27438-27444, 1996 | 253 | 1996 |
| Inhibitory effects of amiodarone and its N‐deethylated metabolite on human cytochrome P450 activities: Prediction of in vivo drug interactions K Ohyama, M Nakajima, M Suzuki, N Shimada, H Yamazaki, T Yokoi British journal of clinical pharmacology 49 (3), 244-253, 2000 | 252 | 2000 |
| Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys-and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes H Yamazaki, K Inoue, K Chiba, N Ozawa, T Kawai, Y Suzuki, JA Goldstein, ... Biochemical pharmacology 56 (2), 243-251, 1998 | 228 | 1998 |
| Oxidation of xenobiotics by recombinant human cytochrome P450 1B1 T Shimada, EMJ Gillam, TR Sutter, PT Strickland, FP Guengerich, ... Drug metabolism and disposition 25 (5), 617-622, 1997 | 224 | 1997 |
| Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes H Yamazaki, A Shibata, M Suzuki, M Nakajima, N Shimada, ... Drug Metabolism and Disposition 27 (11), 1260-1266, 1999 | 216 | 1999 |
| A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approach to predict the contribution with relative activity factor K Ohyama, M Nakajima, S Nakamura, N Shimada, H Yamazaki, T Yokoi Drug metabolism and disposition 28 (11), 1303-1310, 2000 | 213 | 2000 |
Fred GuengerichProfessor of Biochemistry, Vanderbilt UniversityВерификована је имејл адреса на vanderbilt.edu