Прати
Piotr S. Kowalski, PhD
Piotr S. Kowalski, PhD
Associate professor (Senior Lecturer), School of Pharmacy, University College Cork
Верификована је имејл адреса на ucc.ie
Наслов
Навело
Навело
Година
Delivering the messenger: advances in technologies for therapeutic mRNA delivery
PS Kowalski, A Rudra, L Miao, DG Anderson
Molecular Therapy 27 (4), 710-728, 2019
10262019
Advances in the delivery of RNA therapeutics: from concept to clinical reality
JC Kaczmarek, PS Kowalski, DG Anderson
Genome medicine 9, 1-16, 2017
7092017
Engineering circular RNA for potent and stable translation in eukaryotic cells
RA Wesselhoeft, PS Kowalski, DG Anderson
Nature communications 9 (1), 2629, 2018
5872018
RNA circularization diminishes immunogenicity and can extend translation duration in vivo
RA Wesselhoeft, PS Kowalski, FC Parker-Hale, Y Huang, N Bisaria, ...
Molecular cell 74 (3), 508-520. e4, 2019
3542019
Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo
KJ Kauffman, FF Mir, S Jhunjhunwala, JC Kaczmarek, JE Hurtado, ...
Biomaterials 109, 78-87, 2016
2042016
mRNA delivery for therapeutic anti-HER2 antibody expression in vivo
Y Rybakova, PS Kowalski, Y Huang, JT Gonzalez, MW Heartlein, ...
Molecular Therapy 27 (8), 1415-1423, 2019
1862019
Smart biomaterials: recent advances and future directions
PS Kowalski, C Bhattacharya, S Afewerki, R Langer
ACS biomaterials science & engineering 4 (11), 3809-3817, 2018
1842018
Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations
S Farah, JC Doloff, P Müller, A Sadraei, HJ Han, K Olafson, K Vyas, ...
Nature materials 18 (8), 892-904, 2019
1682019
Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy
K Jung, T Heishi, OF Khan, PS Kowalski, J Incio, NN Rahbari, E Chung, ...
The Journal of clinical investigation 127 (8), 3039-3051, 2017
1602017
Reduction of the therapeutic dose of silencing RNA by packaging it in extracellular vesicles via a pre-microRNA backbone
R Reshke, JA Taylor, A Savard, H Guo, LH Rhym, PS Kowalski, MT Trung, ...
Nature biomedical engineering 4 (1), 52-68, 2020
1492020
Ionizable amino‐polyesters synthesized via ring opening polymerization of tertiary amino‐alcohols for tissue selective mRNA delivery
PS Kowalski, U Capasso Palmiero, Y Huang, A Rudra, R Langer, ...
Advanced materials 30 (34), 1801151, 2018
1242018
Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche
M Krohn-Grimberghe, MJ Mitchell, MJ Schloss, OF Khan, G Courties, ...
Nature biomedical engineering 4 (11), 1076-1089, 2020
1102020
Endothelial siRNA delivery in nonhuman primates using ionizable low–molecular weight polymeric nanoparticles
OF Khan, PS Kowalski, JC Doloff, JK Tsosie, V Bakthavatchalu, CB Winn, ...
Science advances 4 (6), eaar8409, 2018
1072018
Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β–induced Serpine1
JV McCann, L Xiao, DJ Kim, OF Khan, PS Kowalski, DG Anderson, ...
The Journal of clinical investigation 129 (4), 1654-1670, 2019
882019
Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo
PS Kowalski, PJ Zwiers, HWM Morselt, JM Kuldo, NGJ Leus, MHJ Ruiters, ...
Journal of controlled release 176, 64-75, 2014
812014
Anti-VCAM-1 and anti-E-selectin SAINT-O-Somes for selective delivery of siRNA into inflammation-activated primary endothelial cells
PS Kowalski, LL Lintermans, HWM Morselt, NGJ Leus, MHJ Ruiters, ...
Molecular pharmaceutics 10 (8), 3033-3044, 2013
742013
Heparin enhances serpin inhibition of the cysteine protease cathepsin L
WJ Higgins, DM Fox, PS Kowalski, JE Nielsen, DM Worrall
Journal of Biological Chemistry 285 (6), 3722-3729, 2010
652010
Design of lipid-based nanoparticles for delivery of therapeutic nucleic acids
MCP Mendonça, A Kont, PS Kowalski, CM O'Driscoll
Drug Discovery Today 28 (3), 103505, 2023
532023
A critical role for Egr-1 during vascular remodelling in pulmonary arterial hypertension
MG Dickinson, PS Kowalski, B Bartelds, MAJ Borgdorff, D van der Feen, ...
Cardiovascular research 103 (4), 573-584, 2014
482014
Targeted siRNA delivery to diseased microvascular endothelial cells—Cellular and molecular concepts
PS Kowalski, NGJ Leus, GL Scherphof, MHJ Ruiters, JAAM Kamps, ...
IUBMB life 63 (8), 648-658, 2011
442011
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