Прати
Hao Chen
Hao Chen
University of Tennessee Health Science Center
Верификована је имејл адреса на uthsc.edu
Наслов
Навело
Навело
Година
Tubulin inhibitor-based antibody-drug conjugates for cancer therapy
H Chen, Z Lin, KE Arnst, DD Miller, W Li
Molecules 22 (8), 1281, 2017
2092017
Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy
KE Arnst, S Banerjee, H Chen, S Deng, DJ Hwang, W Li, DD Miller
Medicinal research reviews 39 (4), 1398-1426, 2019
1402019
DYRK1A inhibitors for disease therapy: Current status and perspectives
T Liu, Y Wang, J Wang, C Ren, H Chen, J Zhang
European journal of medicinal chemistry 229, 114062, 2022
782022
Mechanism of microtubule stabilization by taccalonolide AJ
Y Wang, Y Yu, GB Li, SA Li, C Wu, B Gigant, W Qin, H Chen, Y Wu, ...
Nature communications 8 (1), 15787, 2017
782017
Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis
Z Xiao, J Baudry, L Cao, J Huang, H Chen, CR Yates, W Li, B Dong, ...
The Journal of clinical investigation 128 (1), 157-174, 2018
762018
Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK inhibitors
XY Jin, H Chen, DD Li, AL Li, WY Wang, W Gu
Journal of enzyme inhibition and medicinal chemistry 34 (1), 955-972, 2019
672019
Design, synthesis and in vitro anticancer activity of novel quinoline and oxadiazole derivatives of ursolic acid
W Gu, XY Jin, DD Li, SF Wang, XB Tao, H Chen
Bioorganic & Medicinal Chemistry Letters 27 (17), 4128-4132, 2017
662017
Structural modification of the 3, 4, 5-trimethoxyphenyl moiety in the tubulin inhibitor VERU-111 leads to improved antiproliferative activities
Q Wang, KE Arnst, Y Wang, G Kumar, D Ma, H Chen, Z Wu, J Yang, ...
Journal of medicinal chemistry 61 (17), 7877-7891, 2018
492018
A novel carbazole-based mitochondria-targeted ratiometric fluorescent probe for bisulfite in living cells
G Wang, H Chen, X Chen, Y Xie
Rsc Advances 6 (22), 18662-18666, 2016
492016
Synthesis, characterization and targeting chemotherapy for ovarian cancer of trastuzumab-SN-38 conjugates
Y Yao, L Yu, X Su, Y Wang, W Li, Y Wu, X Cheng, H Zhang, X Wei, ...
Journal of Controlled Release 220, 5-17, 2015
482015
Design, synthesis, and biological evaluation of stable colchicine-binding site tubulin inhibitors 6-aryl-2-benzoyl-pyridines as potential anticancer agents
H Chen, S Deng, N Albadari, MK Yun, S Zhang, Y Li, D Ma, DN Parke, ...
Journal of medicinal chemistry 64 (16), 12049-12074, 2021
402021
Structure–activity relationship study of novel 6-Aryl-2-benzoyl-pyridines as tubulin polymerization inhibitors with potent antiproliferative properties
H Chen, S Deng, Y Wang, N Albadari, G Kumar, D Ma, W Li, SW White, ...
Journal of Medicinal Chemistry 63 (2), 827-846, 2019
392019
A hypoxia-specific and mitochondria-targeted anticancer theranostic agent with high selectivity for cancer cells
M Hu, C Yang, Y Luo, F Chen, F Yang, S Yang, H Chen, Z Cheng, K Li, ...
Journal of materials chemistry B 6 (16), 2413-2416, 2018
352018
Synthesis and biological evaluation of 2-aryl-benzimidazole derivatives of dehydroabietic acid as novel tubulin polymerization inhibitors
TT Miao, XB Tao, DD Li, H Chen, XY Jin, Y Geng, SF Wang, W Gu
RSC advances 8 (31), 17511-17526, 2018
352018
An orally available tubulin inhibitor, VERU-111, suppresses triple-negative breast cancer tumor growth and metastasis and bypasses taxane resistance
S Deng, RI Krutilina, Q Wang, Z Lin, DN Parke, HC Playa, H Chen, ...
Molecular cancer therapeutics 19 (2), 348-363, 2020
342020
Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site
Q Lai, Y Wang, R Wang, W Lai, L Tang, Y Tao, Y Liu, R Zhang, L Huang, ...
European Journal of Medicinal Chemistry 156, 162-179, 2018
342018
1α,20S-Dihydroxyvitamin D3 Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis
Z Lin, H Chen, AY Belorusova, JC Bollinger, EKY Tang, Z Janjetovic, ...
Scientific reports 7 (1), 10193, 2017
342017
Orally available tubulin inhibitor VERU-111 enhances antitumor efficacy in paclitaxel-resistant lung cancer
F Mahmud, S Deng, H Chen, DD Miller, W Li
Cancer letters 495, 76-88, 2020
292020
Dual-target inhibitors of poly (ADP-ribose) polymerase-1 for cancer therapy: Advances, challenges, and opportunities
X Hu, J Zhang, Y Zhang, F Jiao, J Wang, H Chen, L Ouyang, Y Wang
European Journal of Medicinal Chemistry 230, 114094, 2022
282022
Cryptophycin-55/52 based antibody-drug conjugates: Synthesis, efficacy, and mode of action studies
Q Lai, M Wu, R Wang, W Lai, Y Tao, Y Lu, Y Wang, L Yu, R Zhang, ...
European Journal of Medicinal Chemistry 199, 112364, 2020
252020
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