| A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier, KM White, ... Nature 583 (7816), 459-468, 2020 | 4760 | 2020 |
| NMDAR inhibition-independent antidepressant actions of ketamine metabolites P Zanos, R Moaddel, PJ Morris, P Georgiou, J Fischell, GI Elmer, ... Nature 533 (7604), 481-486, 2016 | 1601 | 2016 |
| Structure of the human κ-opioid receptor in complex with JDTic H Wu, D Wacker, M Mileni, V Katritch, GW Han, E Vardy, W Liu, ... Nature 485 (7398), 327-332, 2012 | 1101 | 2012 |
| Structure-based discovery of opioid analgesics with reduced side effects A Manglik, H Lin, DK Aryal, JD McCorvy, D Dengler, G Corder, A Levit, ... Nature 537 (7619), 185-190, 2016 | 1028 | 2016 |
| Automated design of ligands to polypharmacological profiles J Besnard, GF Ruda, V Setola, K Abecassis, RM Rodriguiz, XP Huang, ... Nature 492 (7428), 215-220, 2012 | 892 | 2012 |
| Structural features for functional selectivity at serotonin receptors D Wacker, C Wang, V Katritch, GW Han, XP Huang, E Vardy, JD McCorvy, ... Science 340 (6132), 615-619, 2013 | 824 | 2013 |
| PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome WK Kroeze, MF Sassano, XP Huang, K Lansu, JD McCorvy, PM Giguère, ... Nature structural & molecular biology 22 (5), 362-369, 2015 | 735 | 2015 |
| Structural basis for molecular recognition at serotonin receptors C Wang, Y Jiang, J Ma, H Wu, D Wacker, V Katritch, GW Han, W Liu, ... Science 340 (6132), 610-614, 2013 | 617 | 2013 |
| Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic AA Thompson, W Liu, E Chun, V Katritch, H Wu, E Vardy, XP Huang, ... Nature 485 (7398), 395-399, 2012 | 597 | 2012 |
| A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ... Nature chemical biology 7 (8), 566-574, 2011 | 581 | 2011 |
| Molecular control of δ-opioid receptor signalling G Fenalti, PM Giguere, V Katritch, XP Huang, AA Thompson, V Cherezov, ... Nature 506 (7487), 191-196, 2014 | 569 | 2014 |
| Structure of the human smoothened receptor bound to an antitumour agent C Wang, H Wu, V Katritch, GW Han, XP Huang, W Liu, FY Siu, BL Roth, ... Nature 497 (7449), 338-343, 2013 | 558 | 2013 |
| An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1 KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ... ACS chemical biology 8 (6), 1324-1334, 2013 | 499 | 2013 |
| A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior E Vardy, JE Robinson, C Li, RHJ Olsen, JF DiBerto, PM Giguere, ... Neuron 86 (4), 936-946, 2015 | 438 | 2015 |
| Discovery of β-arrestin–biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy JA Allen, JM Yost, V Setola, X Chen, MF Sassano, M Chen, S Peterson, ... Proceedings of the National Academy of Sciences 108 (45), 18488-18493, 2011 | 398 | 2011 |
| Structure of the nanobody-stabilized active state of the kappa opioid receptor T Che, S Majumdar, SA Zaidi, P Ondachi, JD McCorvy, S Wang, ... Cell 172 (1), 55-67. e15, 2018 | 395 | 2018 |
| Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo AI Abbas, PB Hedlund, XP Huang, TB Tran, HY Meltzer, BL Roth Psychopharmacology 205, 119-128, 2009 | 374 | 2009 |
| Comprehensive characterization of the published kinase inhibitor set JM Elkins, V Fedele, M Szklarz, KR Abdul Azeez, E Salah, J Mikolajczyk, ... Nature biotechnology 34 (1), 95-103, 2016 | 350 | 2016 |
| Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys Y Nagai, N Miyakawa, H Takuwa, Y Hori, K Oyama, B Ji, M Takahashi, ... Nature neuroscience 23 (9), 1157-1167, 2020 | 313 | 2020 |
| Synthon-based ligand discovery in virtual libraries of over 11 billion compounds AA Sadybekov, AV Sadybekov, Y Liu, C Iliopoulos-Tsoutsouvas, ... Nature 601 (7893), 452-459, 2022 | 298 | 2022 |
BL RothDepartment of Pharmacology, University of North Carolina Medical SchoolВерификована је имејл адреса на med.unc.edu
