Caenorhabditis elegans pathways that surveil and defend mitochondria Y Liu, BS Samuel, PC Breen, G Ruvkun Nature 508 (7496), 406-410, 2014 | 320 | 2014 |
MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline CM Phillips, TA Montgomery, PC Breen, G Ruvkun Genes & development 26 (13), 1433-1444, 2012 | 203 | 2012 |
Protein sequence editing of SKN-1A/Nrf1 by peptide: N-glycanase controls proteasome gene expression NJ Lehrbach, PC Breen, G Ruvkun Cell 177 (3), 737-750. e15, 2019 | 119 | 2019 |
The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications SEJ Fischer, TA Montgomery, C Zhang, N Fahlgren, PC Breen, A Hwang, ... PLoS genetics 7 (11), e1002369, 2011 | 107 | 2011 |
A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport RH Dowen, PC Breen, T Tullius, AL Conery, G Ruvkun Genes & development 30 (13), 1515-1528, 2016 | 83 | 2016 |
MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation CM Phillips, BE Montgomery, PC Breen, EF Roovers, YS Rim, TK Ohsumi, ... Current Biology 24 (8), 839-844, 2014 | 65 | 2014 |
Mitochondrial dysfunction in C. elegans activates mitochondrial relocalization and nuclear hormone receptor-dependent detoxification genes K Mao, F Ji, P Breen, A Sewell, M Han, R Sadreyev, G Ruvkun Cell metabolism 29 (5), 1182-1191. e4, 2019 | 61 | 2019 |
Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans SEJ Fischer, Q Pan, PC Breen, Y Qi, Z Shi, C Zhang, G Ruvkun Genes & Development 27 (24), 2678-2695, 2013 | 54 | 2013 |
Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans JA Govindan, E Jayamani, X Zhang, P Breen, J Larkins-Ford, E Mylonakis, ... Nature cell biology 17 (10), 1294-1303, 2015 | 27 | 2015 |
Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response K Mao, P Breen, G Ruvkun PLoS Biology 18 (12), e3000996, 2020 | 15 | 2020 |
Opposing action of the FLR-2 glycoprotein hormone and DRL-1/FLR-4 MAP kinases balance p38-mediated growth and lipid homeostasis in C. elegans SK Torzone, AY Park, PC Breen, NR Cohen, RH Dowen PLoS Biology 21 (9), e3002320, 2023 | 9 | 2023 |
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways K Mao, P Breen, G Ruvkun Proceedings of the National Academy of Sciences 119 (49), e2215966119, 2022 | 9 | 2022 |
moc-6/MOCS2A is necessary for molybdenum cofactor synthesis in C. elegans J Snoozy, PC Breen, G Ruvkun, K Warnhoff Micropublication Biology 2022, 10.17912/micropub. biology. 000531, 2022 | 6 | 2022 |
Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans K Warnhoff, S Bhattacharya, J Snoozy, PC Breen, G Ruvkun Elife 12, RP89173, 2024 | 4 | 2024 |
Prospecting for aptamers in the human genome PC Bevilacqua, PC Breen, P Thaplyal Chemistry & Biology 19 (10), 1218-1220, 2012 | 2 | 2012 |
Hydrogen sulfide mediates the interaction between C. elegans and Actinobacteria from its natural microbial environment O Patange, P Breen, G Arsuffi, G Ruvkun Cell Reports 44 (1), 2025 | 1 | 2025 |
Caenorhabditis elegans inositol hexaphosphate pathways couple to RNA interference and pathogen defense W Xu, Y Sun, P Breen, G Ruvkun, K Mao Proceedings of the National Academy of Sciences 121 (49), e2416982121, 2024 | 1 | 2024 |
A novel gain-of-function mutation in sgk-1 partially suppresses mTORC2 defects D Cully, NR Cohen, PC Breen, MA Newman, RH Dowen microPublication Biology 2024, 10.17912/micropub. biology. 001163, 2024 | 1 | 2024 |
The F-box protein FBXL-5 governs vitellogenesis and lipid homeostasis in C. elegans PC Breen, KG Kanakanui, MA Newman, RH Dowen Frontiers in Cell and Developmental Biology 12, 1389077, 2024 | 1 | 2024 |
Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans K Warnhoff, S Bhattacharya, J Snoozy, PC Breen, G Ruvkun bioRxiv, 2023 | 1 | 2023 |