Прати
Suman Luthra
Suman Luthra
Discovery Pharmaceutical Sciences, Merck & Co., Inc.
Верификована је имејл адреса на MERCK.COM
Наслов
Навело
Навело
Година
Delineating the role of cooperativity in the design of potent PROTACs for BTK
A Zorba, C Nguyen, Y Xu, J Starr, K Borzilleri, J Smith, H Zhu, KA Farley, ...
Proceedings of the National Academy of Sciences 115 (31), E7285-E7292, 2018
3782018
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19
B Boras, RM Jones, BJ Anson, D Arenson, L Aschenbrenner, ...
Nature communications 12 (1), 6055, 2021
2492021
Discovery of a novel inhibitor of coronavirus 3CL protease for the potential treatment of COVID-19
B Boras, RM Jones, BJ Anson, D Arenson, L Aschenbrenner, ...
BioRxiv, 2020.09. 12.293498, 2020
1302020
Cake shrinkage during freeze drying: a combined experimental and theoretical study
S Rambhatla, JP Obert, S Luthra, C Bhugra, MJ Pikal
Pharmaceutical development and technology 10 (1), 33-40, 2005
1002005
Optimization of the secondary drying step in freeze drying using TDLAS technology
SC Schneid, H Gieseler, WJ Kessler, SA Luthra, MJ Pikal
Aaps Pharmscitech 12, 379-387, 2011
792011
Correlation of annealing with chemical stability in lyophilized pharmaceutical glasses
SA Luthra, IM Hodge, M Utz, MJ Pikal
Journal of Pharmaceutical sciences 97 (12), 5240-5251, 2008
612008
Delivering on the promise of protein degraders
MN O’Brien Laramy, S Luthra, MF Brown, DW Bartlett
Nature Reviews Drug Discovery 22 (5), 410-427, 2023
502023
Investigation of the impact of annealing on global molecular mobility in glasses: Optimization for stabilization of amorphous pharmaceuticals
SA Luthra, IM Hodge, MJ Pikal
Journal of pharmaceutical sciences 97 (9), 3865-3882, 2008
432008
Role of coformer and excipient properties on the solid-state stability of theophylline cocrystals
S Koranne, JF Krzyzaniak, S Luthra, KK Arora, R Suryanarayanan
Crystal Growth & Design 19 (2), 868-875, 2019
372019
Challenges in transitioning cocrystals from bench to bedside: Dissociation in prototype drug product environment
S Koranne, A Sahoo, JF Krzyzaniak, S Luthra, KK Arora, ...
Molecular pharmaceutics 15 (8), 3297-3307, 2018
352018
Effects of annealing on enthalpy relaxation in lyophilized disaccharide formulations: Mathematical modeling of DSC curves
SA Luthra, IM Hodge, MJ Pikal
Journal of pharmaceutical sciences 97 (8), 3084-3099, 2008
302008
Chemical stability of amorphous materials: Specific and general media effects in the role of water in the degradation of freeze-dried zoniporide
SA Luthra, EY Shalaev, A Medek, J Hong, MJ Pikal
Journal of pharmaceutical sciences 101 (9), 3110-3123, 2012
282012
The glass transition and sub-Tg-relaxation in pharmaceutical powders and dried proteins by thermally stimulated current
R Reddy, LL Chang, S Luthra, G Collins, C Lopez, SL Shamblin, MJ Pikal, ...
Journal of pharmaceutical sciences 98 (1), 81-93, 2009
282009
Effect of excipient properties, water activity, and water content on the disproportionation of a pharmaceutical salt
MA Patel, S Luthra, SL Shamblin, KK Arora, JF Krzyzaniak, LS Taylor
International Journal of Pharmaceutics 546 (1-2), 226-234, 2018
212018
Solid state 13C NMR investigation of impact of annealing in lyophilized glasses
SA Luthra, MJ Pikal, M Utz
Journal of pharmaceutical sciences 97 (10), 4336-4346, 2008
202008
Impact of solid-state form on the disproportionation of miconazole mesylate
MA Patel, S Luthra, SL Shamblin, K Arora, JF Krzyzaniak, LS Taylor
Molecular Pharmaceutics 15 (1), 40-52, 2018
142018
Salts and polymorphs of 8-fluoro-2-{4-[(methylamino) methyl] phenyl}-1, 3, 4, 5-tetrahydro-6h-azepino [5, 4, 3-cd] indol-6-one
PA Basford, AM Campeta, A Gillmore, MC Jones, E Kougoulos, S Luthra, ...
US Patent 8,754,072, 2014
122014
Carbon–deuterium rotational-echo double-resonance NMR spectroscopy of lyophilized aspartame formulations
SA Luthra, M Utz, EM Gorman, MJ Pikal, EJ Munson, JW Lubach
Journal of pharmaceutical sciences 101 (1), 283-290, 2012
112012
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19. preprint
B Boras
Pharmacology and Toxicology 13, 2020
102020
Assessing the risk of salt disproportionation using crystal structure and surface topography analysis
MA Patel, S Luthra, SL Shamblin, KK Arora, JF Krzyzaniak, LS Taylor
Crystal Growth & Design 18 (11), 7027-7040, 2018
102018
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