Delineating the role of cooperativity in the design of potent PROTACs for BTK A Zorba, C Nguyen, Y Xu, J Starr, K Borzilleri, J Smith, H Zhu, KA Farley, ... Proceedings of the National Academy of Sciences 115 (31), E7285-E7292, 2018 | 378 | 2018 |
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19 B Boras, RM Jones, BJ Anson, D Arenson, L Aschenbrenner, ... Nature communications 12 (1), 6055, 2021 | 249 | 2021 |
Discovery of a novel inhibitor of coronavirus 3CL protease for the potential treatment of COVID-19 B Boras, RM Jones, BJ Anson, D Arenson, L Aschenbrenner, ... BioRxiv, 2020.09. 12.293498, 2020 | 130 | 2020 |
Cake shrinkage during freeze drying: a combined experimental and theoretical study S Rambhatla, JP Obert, S Luthra, C Bhugra, MJ Pikal Pharmaceutical development and technology 10 (1), 33-40, 2005 | 100 | 2005 |
Optimization of the secondary drying step in freeze drying using TDLAS technology SC Schneid, H Gieseler, WJ Kessler, SA Luthra, MJ Pikal Aaps Pharmscitech 12, 379-387, 2011 | 79 | 2011 |
Correlation of annealing with chemical stability in lyophilized pharmaceutical glasses SA Luthra, IM Hodge, M Utz, MJ Pikal Journal of Pharmaceutical sciences 97 (12), 5240-5251, 2008 | 61 | 2008 |
Delivering on the promise of protein degraders MN O’Brien Laramy, S Luthra, MF Brown, DW Bartlett Nature Reviews Drug Discovery 22 (5), 410-427, 2023 | 50 | 2023 |
Investigation of the impact of annealing on global molecular mobility in glasses: Optimization for stabilization of amorphous pharmaceuticals SA Luthra, IM Hodge, MJ Pikal Journal of pharmaceutical sciences 97 (9), 3865-3882, 2008 | 43 | 2008 |
Role of coformer and excipient properties on the solid-state stability of theophylline cocrystals S Koranne, JF Krzyzaniak, S Luthra, KK Arora, R Suryanarayanan Crystal Growth & Design 19 (2), 868-875, 2019 | 37 | 2019 |
Challenges in transitioning cocrystals from bench to bedside: Dissociation in prototype drug product environment S Koranne, A Sahoo, JF Krzyzaniak, S Luthra, KK Arora, ... Molecular pharmaceutics 15 (8), 3297-3307, 2018 | 35 | 2018 |
Effects of annealing on enthalpy relaxation in lyophilized disaccharide formulations: Mathematical modeling of DSC curves SA Luthra, IM Hodge, MJ Pikal Journal of pharmaceutical sciences 97 (8), 3084-3099, 2008 | 30 | 2008 |
Chemical stability of amorphous materials: Specific and general media effects in the role of water in the degradation of freeze-dried zoniporide SA Luthra, EY Shalaev, A Medek, J Hong, MJ Pikal Journal of pharmaceutical sciences 101 (9), 3110-3123, 2012 | 28 | 2012 |
The glass transition and sub-Tg-relaxation in pharmaceutical powders and dried proteins by thermally stimulated current R Reddy, LL Chang, S Luthra, G Collins, C Lopez, SL Shamblin, MJ Pikal, ... Journal of pharmaceutical sciences 98 (1), 81-93, 2009 | 28 | 2009 |
Effect of excipient properties, water activity, and water content on the disproportionation of a pharmaceutical salt MA Patel, S Luthra, SL Shamblin, KK Arora, JF Krzyzaniak, LS Taylor International Journal of Pharmaceutics 546 (1-2), 226-234, 2018 | 21 | 2018 |
Solid state 13C NMR investigation of impact of annealing in lyophilized glasses SA Luthra, MJ Pikal, M Utz Journal of pharmaceutical sciences 97 (10), 4336-4346, 2008 | 20 | 2008 |
Impact of solid-state form on the disproportionation of miconazole mesylate MA Patel, S Luthra, SL Shamblin, K Arora, JF Krzyzaniak, LS Taylor Molecular Pharmaceutics 15 (1), 40-52, 2018 | 14 | 2018 |
Salts and polymorphs of 8-fluoro-2-{4-[(methylamino) methyl] phenyl}-1, 3, 4, 5-tetrahydro-6h-azepino [5, 4, 3-cd] indol-6-one PA Basford, AM Campeta, A Gillmore, MC Jones, E Kougoulos, S Luthra, ... US Patent 8,754,072, 2014 | 12 | 2014 |
Carbon–deuterium rotational-echo double-resonance NMR spectroscopy of lyophilized aspartame formulations SA Luthra, M Utz, EM Gorman, MJ Pikal, EJ Munson, JW Lubach Journal of pharmaceutical sciences 101 (1), 283-290, 2012 | 11 | 2012 |
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19. preprint B Boras Pharmacology and Toxicology 13, 2020 | 10 | 2020 |
Assessing the risk of salt disproportionation using crystal structure and surface topography analysis MA Patel, S Luthra, SL Shamblin, KK Arora, JF Krzyzaniak, LS Taylor Crystal Growth & Design 18 (11), 7027-7040, 2018 | 10 | 2018 |