Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair LR Myler, IF Gallardo, MM Soniat, RA Deshpande, XB Gonzalez, Y Kim, ... Molecular cell 67 (5), 891-898. e4, 2017 | 225 | 2017 |
Poly (ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks MC Caron, AK Sharma, J O’Sullivan, LR Myler, MT Ferreira, A Rodrigue, ... Nature communications 10 (1), 2954, 2019 | 186 | 2019 |
DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP RA Deshpande, LR Myler, MM Soniat, N Makharashvili, L Lee, ... Science advances 6 (2), eaay0922, 2020 | 122 | 2020 |
Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins LR Myler, IF Gallardo, Y Zhou, F Gong, SH Yang, MS Wold, KM Miller, ... Proceedings of the National Academy of Sciences 113 (9), E1170-E1179, 2016 | 116 | 2016 |
Assembly and translocation of a CRISPR-Cas primed acquisition complex KE Dillard, MW Brown, NV Johnson, Y Xiao, A Dolan, E Hernandez, ... Cell 175 (4), 934-946. e15, 2018 | 104 | 2018 |
RPA phosphorylation inhibits DNA resection MM Soniat, LR Myler, HC Kuo, TT Paull, IJ Finkelstein Molecular cell 75 (1), 145-153. e5, 2019 | 100 | 2019 |
Direct activation of ATM by resveratrol under oxidizing conditions JH Lee, Z Guo, LR Myler, S Zheng, TT Paull PLoS One 9 (6), e97969, 2014 | 44 | 2014 |
The evolution of metazoan shelterin LR Myler, CG Kinzig, NK Sasi, G Zakusilo, SW Cai, T de Lange Genes & development 35 (23-24), 1625-1641, 2021 | 39 | 2021 |
Next-generation DNA curtains for single-molecule studies of homologous recombination MM Soniat, LR Myler, JM Schaub, Y Kim, IF Gallardo, IJ Finkelstein Methods in enzymology 592, 259-281, 2017 | 35 | 2017 |
DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres LR Myler, B Toia, CK Vaughan, K Takai, AM Matei, P Wu, TT Paull, ... Nature Structural & Molecular Biology 30 (9), 1346-1356, 2023 | 16 | 2023 |
Eukaryotic resectosomes: A single-molecule perspective LR Myler, IJ Finkelstein Progress in biophysics and molecular biology 127, 119-129, 2017 | 13 | 2017 |
ATR blocks telomerase from converting DNA breaks into telomeres CG Kinzig, G Zakusilo, KK Takai, LR Myler, T de Lange Science 383 (6684), 763-770, 2024 | 11 | 2024 |
Homeodomain proteins directly regulate ATM kinase activity TE Johnson, JH Lee, LR Myler, Y Zhou, TJ Mosley, SH Yang, N Uprety, ... Cell reports 24 (6), 1471-1483, 2018 | 9 | 2018 |
Assembling the human resectosome on DNA curtains MM Soniat, LR Myler, IJ Finkelstein DNA Repair: Methods and Protocols, 225-244, 2019 | 8 | 2019 |
Purification and biophysical characterization of the Mre11-Rad50-Nbs1 complex LR Myler, MM Soniat, X Zhang, RA Deshpande, TT Paull, IJ Finkelstein SMC Complexes: Methods and Protocols, 269-287, 2019 | 7 | 2019 |
Tetrameric TRF2 forms t-loop to protect telomeres from ATM signaling and cNHEJ AM Goldfarb, NK Sasi, TC Dilgen, SW Cai, LR Myler, T de Lange bioRxiv, 2024.06. 27.600884, 2024 | | 2024 |
Single-molecule studies reveal mechanisms of human DNA double-strand break repair LR Myler | | 2018 |
Visualizing the First Steps of Human Double-Strand Break Repair on a Crowded DNA Track L Myler, I Gallardo, Y Kim, TT Paull, IJ Finkelstein Biophysical Journal 110 (3), 65a, 2016 | | 2016 |