Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands EC Petronilho, MM Pedrote, MA Marques, YM Passos, MF Mota, ... Chemical science 12 (21), 7334-7349, 2021 | 70 | 2021 |
Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain PS Kovachev, D Banerjee, LP Rangel, J Eriksson, MM Pedrote, ... Journal of Biological Chemistry 292 (22), 9345-9357, 2017 | 62 | 2017 |
Aggregation tendencies in the p53 family are modulated by backbone hydrogen bonds EA Cino, IN Soares, MM Pedrote, GAP de Oliveira, JL Silva Scientific Reports 6 (1), 32535, 2016 | 62 | 2016 |
Oncogenic gain of function in glioblastoma is linked to mutant p53 amyloid oligomers MM Pedrote, MF Motta, GDS Ferretti, DR Norberto, TCLS Spohr, ... Iscience 23 (2), 2020 | 55 | 2020 |
The status of p53 oligomeric and aggregation states in cancer GAP de Oliveira, EC Petronilho, MM Pedrote, MA Marques, TCRG Vieira, ... Biomolecules 10 (4), 548, 2020 | 53 | 2020 |
Loss of the p53 transactivation domain results in high amyloid aggregation of the Δ40p53 isoform in endometrial carcinoma cells NM Dos Santos, GAP de Oliveira, MR Rocha, MM Pedrote, ... Journal of Biological Chemistry 294 (24), 9430-9439, 2019 | 52 | 2019 |
Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer MM Pedrote, GAP de Oliveira, AL Felix, MF Mota, MA Marques, IN Soares, ... Journal of Biological Chemistry 293 (29), 11374-11387, 2018 | 41 | 2018 |
Allosteric transmission along a loosely structured backbone allows a cardiac troponin C mutant to function with only one Ca2+ ion MA Marques, JR Pinto, AH Moraes, A Iqbal, MTQ de Magalhães, ... Biophysical Journal 112 (3), 62a, 2017 | 18 | 2017 |
Oncogenic gain of function in glioblastoma is linked to mutant p53 amyloid oligomers. iScience 23, 100820 MM Pedrote, MF Motta, GDS Ferretti, DR Norberto, T Spohr, FRS Lima, ... Article CAS PubMed PubMed Central, 2020 | 6 | 2020 |
High pressure studies on the misfolding and aggregation of p53 in cancer and of α-synuclein in Parkinson’s disease GAP de Oliveira, MA Marques, MM Pedrote, JL Silva High Pressure Research 39 (2), 193-201, 2019 | 5 | 2019 |
Water leakage pathway leads to internal hydration of the p53 core domain IDM Lima, MM Pedrote, MA Marques, GS Sousa, JL Silva, ... Biochemistry 62 (1), 35-43, 2022 | 3 | 2022 |
Amyloid Oligomers of Mutant p53 in Living Cells Result in Oncogenic Gain of Function in Glioblastoma MM Pedrote, MF Motta, DR Norberto, TCLS Spohr, FRS Lima, E Gratton, ... Available at SSRN 3445669, 2019 | | 2019 |
Prion-like aggregation of p53 in breast cancer and glioblastoma: New targets for antitumoral drugs JL Silva, DCF da Costa, FRS Lima, MM Pedrote, GGAP Oliveira, ... PRION 8, 138-138, 2014 | | 2014 |
Δ40p53 isoform explains p53 aggregation NM dos Santos, GAP de Oliveira, MR Rocha, MM Pedrote, ... | | |