| Can cysteine protease cross-class inhibitors achieve selectivity? L Cianni, CW Feldmann, E Gilberg, M Gütschow, L Juliano, A Leitao, ... Journal of medicinal chemistry 62 (23), 10497-10525, 2019 | 66 | 2019 |
| Experimental study and computational modelling of cruzain cysteine protease inhibition by dipeptidyl nitriles AM Dos Santos, L Cianni, D De Vita, F Rosini, A Leitão, CA Laughton, ... Physical Chemistry Chemical Physics 20 (37), 24317-24328, 2018 | 54 | 2018 |
| A comparative study of warheads for design of cysteine protease inhibitors DG Silva, JFR Ribeiro, D De Vita, L Cianni, CH Franco, LH Freitas-Junior, ... Bioorganic & medicinal chemistry letters 27 (22), 5031-5035, 2017 | 51 | 2017 |
| Assessment of the cruzain cysteine protease reversible and irreversible covalent inhibition mechanism JRA Silva, L Cianni, D Araujo, PHJ Batista, D de Vita, F Rosini, A Leitao, ... Journal of chemical information and modeling 60 (3), 1666-1677, 2020 | 43 | 2020 |
| Leveraging the cruzain S3 subsite to increase affinity for reversible covalent inhibitors L Cianni, G Sartori, F Rosini, D De Vita, G Pires, BR Lopes, A Leitão, ... Bioorganic Chemistry 79, 285-292, 2018 | 28 | 2018 |
| Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells E Micheli, A Altieri, L Cianni, C Cingolani, S Iachettini, A Bianco, ... Biochimie 125, 223-231, 2016 | 28 | 2016 |
| Predicting the affinity of halogenated reversible covalent inhibitors through relative binding free energy J Lameira, V Bonatto, L Cianni, F dos Reis Rocho, A Leitão, CA Montanari Physical Chemistry Chemical Physics 21 (44), 24723-24730, 2019 | 25 | 2019 |
| Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement JC Gomes, L Cianni, J Ribeiro, F dos Reis Rocho, SCM Silva, PHJ Batista, ... Bioorganic & Medicinal Chemistry 27 (22), 115083, 2019 | 22 | 2019 |
| Natural aromatic compounds as scaffolds to develop selective G-quadruplex ligands: from previously reported berberine derivatives to new palmatine analogues M Franceschin, L Cianni, M Pitorri, E Micheli, S Cacchione, C Frezza, ... Molecules 23 (6), 1423, 2018 | 21 | 2018 |
| Mapping the S1 and S1’subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents L Cianni, C Lemke, E Gilberg, C Feldmann, F Rosini, FR Rocho, ... PLoS neglected tropical diseases 14 (3), e0007755, 2020 | 17 | 2020 |
| Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases L Cianni, F dos Reis Rocho, F Rosini, V Bonatto, JFR Ribeiro, J Lameira, ... Bioorganic Chemistry 101, 104039, 2020 | 11 | 2020 |
| On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors V Bonatto, PHJ Batista, L Cianni, D De Vita, DG Silva, R Cedron, ... RSC Medicinal Chemistry 11 (11), 1275-1284, 2020 | 10 | 2020 |
| Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L L Cianni, FDR Rocho, V Bonatto, FCP Martins, J Lameira, A Leitao, ... Bioorganic & Medicinal Chemistry 29, 115827, 2021 | 9 | 2021 |
| Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor JFR Ribeiro, L Cianni, C Li, TG Warwick, D De Vita, F Rosini, ... Bioorganic & Medicinal Chemistry 28 (22), 115743, 2020 | 9 | 2020 |
| N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization C Lemke, L Cianni, C Feldmann, E Gilberg, J Yin, F dos Reis Rocho, ... Bioorganic & Medicinal Chemistry Letters 30 (18), 127420, 2020 | 5 | 2020 |
| Druglike, 18F-labeled PET Tracers Targeting Fibroblast Activation Protein M Tanc, N Filippi, Y Van Rymenant, S Grintsevich, I Pintelon, ... Journal of Medicinal Chemistry 67 (9), 7068-7087, 2024 | 3 | 2024 |
| Molecular design aided by random forests and synthesis of potent trypanocidal agents as cruzain inhibitors for Chagas disease treatment S de Albuquerque, L Cianni, D de Vita, C Duque, ASM Gomes, P Gomes, ... Chemical Biology & Drug Design 96 (3), 948-960, 2020 | 2 | 2020 |
| The Effect of Dipeptidyl Nitrile Derivatives on Pancreatic Ductal Adenocarcinoma Cells In Vitro SM Botelho, F dos Reis Rocho, L Cianni, CA Montanari, A Leitão Current Chemical Biology 15 (4), 278-286, 2021 | 1 | 2021 |
| Selective interactions with various G-quadruplex DNA forming sequences by berberine and palmatine analogues M Franceschin, L Cianni, M Pitorri, E Micheli, S Cacchione, C Frezza, ... Preprints, 2018 | 1 | 2018 |
| Inhibitors of fibroblast activation protein K Augustyns, L BEROSKE, L CIANNI, ID Meester, F ELVAS, N FILIPPI, ... WO Patent WO2023233023A1, 2023 | | 2023 |
