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Tao-Hsin Chang
Tao-Hsin Chang
Senior Scientist, Integer Bio; Visiting Scientist, University of Oxford
Verifierad e-postadress på ntu.edu.tw
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Notum deacylates Wnt proteins to suppress signalling activity
S Kakugawa, PF Langton, M Zebisch, SA Howell, TH Chang, Y Liu, ...
Nature 519 (7542), 187-192, 2015
4392015
Bisphosphonates target multiple sites in both cis-and trans-prenyltransferases
RT Guo, R Cao, PH Liang, TP Ko, TH Chang, MP Hudock, WY Jeng, ...
Proceedings of the National Academy of Sciences 104 (24), 10022-10027, 2007
2312007
Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan
TH Chang, FL Hsieh, M Zebisch, K Harlos, J Elegheert, EY Jones
Elife 4, e06554, 2015
1392015
Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation
TH Chang, FL Hsieh, TP Ko, KH Teng, PH Liang, AHJ Wang
The Plant Cell 22 (2), 454-467, 2010
1282010
Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination
TH Chang, RT Guo, TP Ko, AHJ Wang, PH Liang
Journal of Biological Chemistry 281 (21), 14991-15000, 2006
1152006
Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation†
MP Hudock, Y Zhang, RT Guo, R Cao, JH No, PH Liang, TP Ko, ...
Journal of medicinal chemistry 51 (18), 5594-5607, 2008
972008
Structure and mechanism of an Arabidopsis medium/long-chain-length prenyl pyrophosphate synthase
FL Hsieh, TH Chang, TP Ko, AHJ Wang
Plant physiology 155 (3), 1079-1090, 2011
942011
Crystal structure of vaccinia viral A27 protein reveals a novel structure critical for its function and complex formation with A26 protein
TH Chang, SJ Chang, FL Hsieh, TP Ko, CT Lin, MR Ho, I Wang, STD Hsu, ...
PLoS pathogens 9 (8), e1003563, 2013
472013
Structure of the RECK CC domain, an evolutionary anomaly
TH Chang, FL Hsieh, PM Smallwood, SB Gabelli, J Nathans
Proceedings of the National Academy of Sciences 117 (26), 15104-15111, 2020
142020
Structural insights into plasmalemma vesicle-associated protein (PLVAP): Implications for vascular endothelial diaphragms and fenestrae
TH Chang, FL Hsieh, X Gu, PM Smallwood, JM Kavran, SB Gabelli, ...
Proceedings of the National Academy of Sciences 120 (14), e2221103120, 2023
112023
Antibody Display of cell surface receptor Tetraspanin12 and SARS-CoV-2 spike protein
FL Hsieh, TH Chang
bioRxiv, 2021.05. 29.446300, 2021
62021
Enhanced specificity of mint geranyl pyrophosphate synthase by modifying the R-loop interactions
FL Hsieh, TH Chang, TP Ko, AHJ Wang
Journal of molecular biology 404 (5), 859-873, 2010
52010
Control Activity of Yeast Geranylgeranyl Diphosphate Synthase from Dimer Interface through H-Bonds and Hydrophobic Interaction
CK Chang, KH Teng, SW Lin, TH Chang, PH Liang
Biochemistry 52 (16), 2783-2792, 2013
32013
Structural insights into Frizzled3 through nanobody modulators
J Hillier, Y Zhao, L Carrique, T Malinauskas, RR Ruza, TH Chang, G Yi, ...
Nature Communications 15 (1), 7228, 2024
12024
Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein
FL Hsieh, TH Chang, SB Gabelli, J Nathans
Proceedings of the National Academy of Sciences 120 (20), e2217096120, 2023
12023
Structural insights into Frizzled assembly by acylated Wnt and Frizzled Connector domain
TH Chang, FL Hsieh, K Harlos, EY Jones
bioRxiv, 2022.09. 29.510206, 2022
12022
Structural basis of Norrin recognition by Lgr4/5/6
TH Chang, K Harlos, FL Hsieh, EY Jones
bioRxiv, 2022.09. 29.510199, 2022
12022
Utility of protein–protein binding surfaces composed of anti-parallel alpha-helices and beta-sheets selected by phage display
N Zhu, PM Smallwood, A Rattner, TH Chang, J Williams, Y Wang, ...
Journal of Biological Chemistry 300 (5), 2024
2024
Antibody Display Technology (ADbody) to Present Challenging and Unstable Target Proteins on Antibodies
FL Hsieh, TH Chang
Genotype Phenotype Coupling: Methods and Protocols, 373-382, 2023
2023
Native SAD data collection using microbeam at NSLSII
K Phan, W Shi, T Chang, T Aytenfisu, A Soares, J Jakoncic, ...
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 76, A58-A58, 2020
2020
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