X. Long Zheng, M.D., Ph.D.

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Wenjing Cao, M.D., Ph.D.University of Wisconsin-MadisonVerifierad e-postadress på wisc.edu
Spero CatalandProfessor, Ohio State UniversityVerifierad e-postadress på osumc.edu
h.kwaanFeinberg School of MedicineVerifierad e-postadress på northwestern.edu
Huy P. PhamAssociate ProfessorVerifierad e-postadress på usc.edu
Christopher SkipwithDepartment of Biotechnology, Johns Hopkins UniversityVerifierad e-postadress på jhu.edu
Don SiegelProfessor of Pathology and Laboaratory Medicine, University of PennsylvaniaVerifierad e-postadress på pennmedicine.upenn.edu
Flora PeyvandiUniversità degli Studi di MilanoVerifierad e-postadress på unimi.it
Mohammad S. Abdelgawwad, MD, PhDUniversity of Alabama at BirminghamVerifierad e-postadress på uab.edu
Reem Mustafa, MD, PhD, MPH, FASNUniversity of KansasVerifierad e-postadress på kumc.edu
Paul COPPOVerifierad e-postadress på aphp.fr
Alfonso IorioProfessor and Chair, Department of Health Research Methods, Evidence, and Impact, McMasterVerifierad e-postadress på mcmaster.ca
Friedrich ScheiflingerExecutive Vice President, General Manager Evotec Gene Therapy, AustriaVerifierad e-postadress på evotec.com
Menaka PaiProfessor of Hematology & Thromboembolism, Department of Medicine, McMaster UniversityVerifierad e-postadress på mcmaster.ca
Liz StaleyAssistant Professor, University of WashingtonVerifierad e-postadress på uw.edu
Yoshihiro FujimuraProfessor Em of Nara Medical University and Senior Fellow of Japanese Red Cross Blood CenterVerifierad e-postadress på kk.bbc.jrc.or.jp
Robin LorenzExecutive Director, Research Pathology, Genentech, Inc.Verifierad e-postadress på gene.com
Mortimer PonczProfessor of Pediatrics, University of PennsylvaniaVerifierad e-postadress på chop.edu
Vikram Gopalakrishna PillaiSenior Scientist, University of Kansas Medical CenterVerifierad e-postadress på kumc.edu
Robert C. BauerAssistant Professor of Medical Science, Columbia UniversityVerifierad e-postadress på columbia.edu
Junichiro TohyamaPerelman School of Medicine at The University of Pennsylvania Department of Pathology and LaboratoryVerifierad e-postadress på mail.med.upenn.edu

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X. Long Zheng, M.D., Ph.D.

Professor and Chair of Pathology and Laboratory Medicine

Verifierad e-postadress på kumc.edu

Thrombosis Haemostasis Thrombotic Microangiopathy


Titel Sortera efter citat Sortera efter år Sortera efter titel	Citeras av Citeras av	År
Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura X Zheng, D Chung, TK Takayama, EM Majerus, JE Sadler, K Fujikawa Journal of Biological Chemistry 276 (44), 41059-41063, 2001	1117	2001
Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic … XL Zheng, RM Kaufman, LT Goodnough, JE Sadler Blood 103 (11), 4043-4049, 2004	553	2004
ISTH guidelines for treatment of thrombotic thrombocytopenic purpura XL Zheng, SK Vesely, SR Cataland, P Coppo, B Geldziler, A Iorio, ... Journal of Thrombosis and Haemostasis 18 (10), 2496-2502, 2020	342	2020
Pathogenesis of thrombotic microangiopathies XL Zheng, JE Sadler Annu. Rev. Pathol. Mech. Dis. 3 (1), 249-277, 2008	298	2008
ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura XL Zheng Annual review of medicine 66 (1), 211-225, 2015	294	2015
ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura XL Zheng, SK Vesely, SR Cataland, P Coppo, B Geldziler, A Iorio, ... Journal of Thrombosis and Haemostasis 18 (10), 2486-2495, 2020	275	2020
Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13 X Zheng, K Nishio, EM Majerus, JE Sadler Journal of Biological Chemistry 278 (32), 30136-30141, 2003	248	2003
Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice J Xue, Q Wu, LA Westfield, EA Tuley, D Lu, Q Zhang, K Shim, X Zheng, ... Proceedings of the National Academy of Sciences 95 (13), 7603-7607, 1998	198	1998
Binding of platelet glycoprotein Ibα to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13 K Nishio, PJ Anderson, XL Zheng, JE Sadler Proceedings of the National Academy of Sciences 101 (29), 10578-10583, 2004	194	2004
Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice M Dewerchin, Z Liang, L Moons, P Carmeliet, FJ Castellino, D Collen, ... Thrombosis and haemostasis 83 (02), 185-190, 2000	189	2000
Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics M Saha, JK McDaniel, XL Zheng Journal of Thrombosis and Haemostasis 15 (10), 1889-1900, 2017	175	2017
Structure–function and regulation of ADAMTS‐13 protease XL Zheng Journal of Thrombosis and Haemostasis 11, 11-23, 2013	173	2013
Remission of chronic thrombotic thrombocytopenic purpura after treatment with cyclophosphamide and rituximab X Zheng, AM Pallera, LT Goodnough, JE Sadler, MA Blinder Annals of internal medicine 138 (2), 105-108, 2003	170	2003
Cleavage of the ADAMTS13 propeptide is not required for protease activity EM Majerus, X Zheng, EA Tuley, JE Sadler Journal of Biological Chemistry 278 (47), 46643-46648, 2003	168	2003
Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura XL Zheng, HM Wu, D Shang, E Falls, CG Skipwith, SR Cataland, ... Haematologica 95 (9), 1555, 2010	157	2010
Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells WJ Cao, M Niiya, XW Zheng, DZ Shang, XL Zheng Journal of Thrombosis and Haemostasis 6 (7), 1233-1235, 2008	156	2008
The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow P Zhang, W Pan, AH Rux, BS Sachais, XL Zheng Blood, The Journal of the American Society of Hematology 110 (6), 1887-1894, 2007	152	2007
Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura C Jian, J Xiao, L Gong, CG Skipwith, SY Jin, HC Kwaan, XL Zheng Blood, The Journal of the American Society of Hematology 119 (16), 3836-3843, 2012	149	2012
The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor J Ai, P Smith, S Wang, P Zhang, XL Zheng Journal of Biological Chemistry 280 (33), 29428-29434, 2005	147	2005
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site TJ Raife, W Cao, BS Atkinson, B Bedell, RR Montgomery, SR Lentz, ... Blood, The Journal of the American Society of Hematology 114 (8), 1666-1674, 2009	144	2009

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