Jose M.P. Freije

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Alberto M PendasResearch Scientist of the Spanish Research Council (CSIC) Verifierad e-postadress på usal.es
Guillermo MariñoUniversity of OviedoVerifierad e-postadress på uniovi.es
Guido KroemerUniversité de Paris Cité, Hôpital Européen George Pompidou - AP-HP, Gustave Roussy Cancer CampusVerifierad e-postadress på inserm.fr
Andrew RamsayPostdoctoral researcherVerifierad e-postadress på uniovi.es
Vicente AndresCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Verifierad e-postadress på cnic.es
Karl TryggvasonProfessor, Karolinska Institute, Stockholm & Duke-NUS, SingaporeVerifierad e-postadress på tryggvason.com
Zhongjun ZhouThe University of Hong Kong, Faculty of MedicineVerifierad e-postadress på hku.hk
Álvaro Fernández Fernández (0000-0...Universidad de OviedoVerifierad e-postadress på uniovi.es
Fanjul-Fernandez MiriamPostdoctoral Researcher, Royal Children's hospitalVerifierad e-postadress på mcri.edu.au
Jorge ToliviaCatedrático de UniversidadVerifierad e-postadress på uniovi.es
Lorenzo GalluzziWeill Cornell Medical CollegeVerifierad e-postadress på med.cornell.edu
Paloma Morán (https://orcid.org/0000-...Professor of Genetics. CIM. Universidad de Vigo (RoR:05rdf8595). SpainVerifierad e-postadress på uvigo.es
Georgina S. ButlerResearch Associate, Center for Blood Research, University of British Columbia, Canada.Verifierad e-postadress på ubc.ca
Walter K. SchmidtUniversity of GeorgiaVerifierad e-postadress på uga.edu
yoshikazu takadaProfessor of Dermatology, Biochemistry and molecular medicineVerifierad e-postadress på ucdavis.edu
Piero CrespoIBBTEC, CSICVerifierad e-postadress på unican.es
Allan BradleyDept of Medicine, Cambridge University, UKVerifierad e-postadress på cam.ac.uk
Raffaella SantoroUniversity of ZurichVerifierad e-postadress på dmmd.uzh.ch
Juan Ramon PeinadoUCLMVerifierad e-postadress på uclm.es
Vincenzo CalvaneseUniversity College London, LMCBVerifierad e-postadress på ucl.ac.uk

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Jose M.P. Freije

Professor, Biochemistry and Molecular Biology, Univ. Oviedo

Verifierad e-postadress på uniovi.es

Cancer aging proteases


Titel Sortera efter citat Sortera efter år Sortera efter titel	Citeras av Citeras av	År
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia XS Puente, M Pinyol, V Quesada, L Conde, GR Ordóñez, N Villamor, ... Nature 475 (7354), 101-105, 2011	1955	2011
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia V Quesada, L Conde, N Villamor, GR Ordóñez, P Jares, L Bassaganyas, ... Nature genetics 44 (1), 47-52, 2012	1291	2012
Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas JM Freije, I Diez-Itza, M Balbín, LM Sánchez, R Blasco, J Tolivia, ... Journal of Biological Chemistry 269 (24), 16766-16773, 1994	985	1994
Metabolic control of longevity C López-Otín, L Galluzzi, JMP Freije, F Madeo, G Kroemer Cell 166 (4), 802-821, 2016	786	2016
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase–deficient mice AM Pendás, Z Zhou, J Cadiñanos, JMP Freije, J Wang, K Hultenby, ... Nature genetics 31 (1), 94-99, 2002	661	2002
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation I Varela, J Cadinanos, AM Pendás, A Gutiérrez-Fernández, AR Folgueras, ... Nature 437 (7058), 564-568, 2005	571	2005
Deubiquitinases in cancer: new functions and therapeutic options JM Fraile, V Quesada, D Rodríguez, JMP Freije, C López-Otín Oncogene 31 (19), 2373-2388, 2012	541	2012
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice C Bárcena, R Valdés-Mas, P Mayoral, C Garabaya, S Durand, ... Nature medicine 25 (8), 1234-1242, 2019	508	2019
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging I Varela, S Pereira, AP Ugalde, CL Navarro, MF Suárez, P Cau, ... Nature medicine 14 (7), 767-772, 2008	497	2008
Splicing-directed therapy in a new mouse model of human accelerated aging FG Osorio, CL Navarro, J Cadiñanos, IC López-Mejía, PM Quirós, ... Science translational medicine 3 (106), 106ra107-106ra107, 2011	481	2011
Chromosomal mapping and nucleotide sequence of two tandem repeats of Atlantic salmon 5S rDNA AM Pendás, P Moran, JP Freije, E Garcia-Vazquez Cytogenetic and Genome Research 67 (1), 31-36, 1994	366	1994
Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors CL Navarro, J Cadinanos, AD Sandre-Giovannoli, R Bernard, S Courrier, ... Human molecular genetics 14 (11), 1503-1513, 2005	354	2005
Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors E Llano, AM Pendás, JP Freije, A Nakano, V Knäuper, G Murphy, ... Cancer research 59 (11), 2570-2576, 1999	344	1999
Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response FG Osorio, C Bárcena, C Soria-Valles, AJ Ramsay, F de Carlos, J Cobo, ... Genes & development 26 (20), 2311-2324, 2012	322	2012
Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-α convertase activity but does not activate pro-MMP2 WR English, XS Puente, JMP Freije, V Knäuper, A Amour, ... Journal of Biological Chemistry 275 (19), 14046-14055, 2000	302	2000
Aging and chronic DNA damage response activate a regulatory pathway involving miR‐29 and p53 AP Ugalde, AJ Ramsay, J De La Rosa, I Varela, G Mariño, J Cadiñanos, ... The EMBO journal 30 (11), 2219-2232, 2011	292	2011
Differential effects of transforming growth factor-beta on the expression of collagenase-1 and collagenase-3 in human fibroblasts. JA Uria, MG Jimenez, M Balbin, JM Freije, C Lopez-Otin The Journal of biological chemistry 273 (16), 9769-9777, 1998	280	1998
A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential. NJ MacDonald, A De La Rosa, MA Benedict, JM Freije, H Krutsch, ... Journal of Biological Chemistry 268 (34), 25780-25789, 1993	268	1993
Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome XS Puente, V Quesada, FG Osorio, R Cabanillas, J Cadiñanos, JM Fraile, ... The American Journal of Human Genetics 88 (5), 650-656, 2011	252	2011
Matrix metalloproteinases and tumor progression JMP Freije, M Balbín, AM Pendás, LM Sánchez, XS Puente, C López-Otín New Trends in Cancer for the 21 st Century: Proceedings of the International …, 2003	237	2003

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