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Giuseppe Locatelli
Giuseppe Locatelli
NIBR Novartis, Basel
Verifierad e-postadress på novartis.com
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Origin, fate and dynamics of macrophages at central nervous system interfaces
T Goldmann, P Wieghofer, MJC Jordão, F Prutek, N Hagemeyer, ...
Nature immunology 17 (7), 797-805, 2016
11332016
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation
MJC Jordão, R Sankowski, SM Brendecke, Sagar, G Locatelli, YH Tai, ...
Science 363 (6425), eaat7554, 2019
7372019
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
AG Spiteri, CL Wishart, R Pamphlett, G Locatelli, NJC King
Acta neuropathologica, 1-46, 2022
1582022
Primary oligodendrocyte death does not elicit anti-CNS immunity
G Locatelli, S Wörtge, T Buch, B Ingold, F Frommer, B Sobottka, M Krüger, ...
Nature neuroscience 15 (4), 543-550, 2012
1572012
Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model
G Locatelli, D Theodorou, A Kendirli, MJC Jordao, O Staszewski, ...
Nature neuroscience 21 (9), 1196-1208, 2018
1482018
Mouse redox histology using genetically encoded probes
Y Fujikawa, LP Roma, MC Sobotta, AJ Rose, MB Diaz, G Locatelli, ...
Science signaling 9 (419), rs1-rs1, 2016
862016
Dwellers and trespassers: mononuclear phagocytes at the borders of the central nervous system
DC Ivan, S Walthert, K Berve, J Steudler, G Locatelli
Frontiers in immunology 11, 609921, 2021
342021
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation. Science 363: eaat7554
MJC Jordão, R Sankowski, SM Brendecke, G Sagar, G Locatelli, YH Tai, ...
252019
Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation
DC Ivan, KC Berve, S Walthert, G Monaco, K Borst, E Bouillet, F Ferreira, ...
Acta neuropathologica communications 11 (1), 35, 2023
222023
Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes
J Steudler, T Ecott, DC Ivan, E Bouillet, S Walthert, K Berve, TP Dick, ...
Glia 70 (11), 2045-2061, 2022
212022
Central Nervous System Barriers Impact Distribution and Expression of iNOS and Arginase-1 in Infiltrating Macrophages During Neuroinflammation
L Ivan, Walthert
Frontiers in Immunology, 2021
182021
The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm
F Gasparri, F Sola, G Locatelli, M Muzio
FEBS letters 574 (1-3), 13-19, 2004
142004
Semaphorin 7A restricts serotonergic innervation and ensures recovery after spinal cord injury
K Loy, J Fourneau, N Meng, C Denecke, G Locatelli, FM Bareyre
Cellular and Molecular Life Sciences 78 (6), 2911-2927, 2021
132021
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions
YH Tai, D Engels, G Locatelli, I Emmanouilidis, C Fecher, D Theodorou, ...
Nature metabolism 5 (8), 1364-1381, 2023
122023
Mature oligodendrocytes actively increase in vivo cytoskeletal plasticity following CNS damage
G Locatelli, A Baggiolini, B Schreiner, P Palle, A Waisman, B Becher, ...
Journal of neuroinflammation 12, 1-12, 2015
102015
A phase I study of ATR inhibitor gartisertib (M4344) as a single agent and in combination with carboplatin in patients with advanced solid tumours
HA Burris, J Berlin, T Arkenau, GM Cote, MP Lolkema, J Ferrer-Playan, ...
British Journal of Cancer 130 (7), 1131-1140, 2024
92024
Relationship among DDR gene mutations, TMB and PD-L1 in solid tumour genomes identified using clinically actionable biomarker assays
D Wang, B Elenbaas, K Murugesan, K Shah, M Montesion, I Gounaris, ...
NPJ Precision Oncology 7 (1), 103, 2023
92023
First-in-human study of the ataxia telangiectasia and Rad3-related (ATR) inhibitor tuvusertib (M1774) as monotherapy in patients with solid tumors
TA Yap, AW Tolcher, R Plummer, JK Mukker, M Enderlin, C Hicking, ...
Clinical Cancer Research 30 (10), 2057-2067, 2024
82024
Integrating transcriptomic datasets across neurological disease identifies unique myeloid subpopulations driving disease‐specific signatures
CL Wishart, AG Spiteri, G Locatelli, NJC King
Glia 71 (4), 904-925, 2023
82023
Beyond trial and error: a systematic development of liposomes targeting primary macrophages
F Weber, DC Ivan, ST Proulx, G Locatelli, S Aleandri, P Luciani
Advanced NanoBiomed Research 1 (3), 2000098, 2021
82021
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Artiklar 1–20