Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target MM Alam, A Sanchez-Azqueta, O Janha, EL Flannery, A Mahindra, ... Science 365 (6456), eaau1682, 2019 | 78 | 2019 |
Current status of experimental models for the study of malaria NV Simwela, AP Waters Parasitology 149 (6), 729-750, 2022 | 35 | 2022 |
Experimentally Engineered Mutations in a Ubiquitin Hydrolase, UBP-1, Modulate In Vivo Susceptibility to Artemisinin and Chloroquine in Plasmodium berghei NV Simwela, KR Hughes, AB Roberts, MT Rennie, MP Barrett, AP Waters Antimicrobial agents and chemotherapy 64 (7), 10.1128/aac. 02484-19, 2020 | 28 | 2020 |
Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That Is Reversed by Proteasome Inhibition NV Simwela, BH Stokes, D Aghabi, M Bogyo, DA Fidock, AP Waters MBio 11 (6), 10.1128/mbio. 02312-20, 2020 | 20 | 2020 |
Mammalian Deubiquitinating Enzyme Inhibitors Display in Vitro and in Vivo Activity against Malaria Parasites and Potentiate Artemisinin Action NV Simwela, KR Hughes, MT Rennie, MP Barrett, AP Waters ACS Infectious Diseases 7 (2), 333-346, 2021 | 11 | 2021 |
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance W Zhan, D Li, SB Subramanyaswamy, YJ Liu, C Yang, H Zhang, JC Harris, ... Cell chemical biology 30 (5), 457-469. e11, 2023 | 8 | 2023 |
The use of molecular technology to investigate trypanosome infections in tsetse flies at Liwonde Wild Life Reserve SF Nayupe Malawi Medical Journal 31 (4), 233-237, 2019 | 6 | 2019 |
Genome-wide screen of Mycobacterium tuberculosis-infected macrophages identified the GID/CTLH complex as a determinant of intracellular bacterial growth NV Simwela, L Johnston, P Pavinski Bitar, E Jaecklein, C Altier, ... BiorXiv, 2024.05. 06.592714, 2024 | 3 | 2024 |
Genome-wide screen of Mycobacterium tuberculosis-infected macrophages revealed GID/CTLH complex-mediated modulation of bacterial growth NV Simwela, L Johnston, PP Bitar, E Jaecklein, C Altier, CM Sassetti, ... Nature Communications 15 (1), 9322, 2024 | 2 | 2024 |
How macrophage heterogeneity affects tuberculosis disease and therapy DG Russell, NV Simwela, JT Mattila, JA Flynn, HC Mwandumba, D Pisu Nature Reviews Immunology, 1-15, 2025 | 1 | 2025 |
Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis NV Simwela, E Jaecklein, CM Sassetti, DG Russell bioRxiv, 2024 | 1 | 2024 |
A conserved metabolic signature associated with response to fast-acting anti-malarial agents NV Simwela, WA Guiguemde, J Straimer, C Regnault, BH Stokes, ... Microbiology spectrum 11 (6), e03976-22, 2023 | 1 | 2023 |
Drug action and resistance in malaria parasites: experimental genetics models and biochemical features of fast acting novel antimalarials NV Simwela University of Glasgow, 2020 | | 2020 |