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Nelson Simwela
Nelson Simwela
Verifierad e-postadress på cornell.edu
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Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target
MM Alam, A Sanchez-Azqueta, O Janha, EL Flannery, A Mahindra, ...
Science 365 (6456), eaau1682, 2019
782019
Current status of experimental models for the study of malaria
NV Simwela, AP Waters
Parasitology 149 (6), 729-750, 2022
352022
Experimentally Engineered Mutations in a Ubiquitin Hydrolase, UBP-1, Modulate In Vivo Susceptibility to Artemisinin and Chloroquine in Plasmodium berghei
NV Simwela, KR Hughes, AB Roberts, MT Rennie, MP Barrett, AP Waters
Antimicrobial agents and chemotherapy 64 (7), 10.1128/aac. 02484-19, 2020
282020
Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That Is Reversed by Proteasome Inhibition
NV Simwela, BH Stokes, D Aghabi, M Bogyo, DA Fidock, AP Waters
MBio 11 (6), 10.1128/mbio. 02312-20, 2020
202020
Mammalian Deubiquitinating Enzyme Inhibitors Display in Vitro and in Vivo Activity against Malaria Parasites and Potentiate Artemisinin Action
NV Simwela, KR Hughes, MT Rennie, MP Barrett, AP Waters
ACS Infectious Diseases 7 (2), 333-346, 2021
112021
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance
W Zhan, D Li, SB Subramanyaswamy, YJ Liu, C Yang, H Zhang, JC Harris, ...
Cell chemical biology 30 (5), 457-469. e11, 2023
82023
The use of molecular technology to investigate trypanosome infections in tsetse flies at Liwonde Wild Life Reserve
SF Nayupe
Malawi Medical Journal 31 (4), 233-237, 2019
62019
Genome-wide screen of Mycobacterium tuberculosis-infected macrophages identified the GID/CTLH complex as a determinant of intracellular bacterial growth
NV Simwela, L Johnston, P Pavinski Bitar, E Jaecklein, C Altier, ...
BiorXiv, 2024.05. 06.592714, 2024
32024
Genome-wide screen of Mycobacterium tuberculosis-infected macrophages revealed GID/CTLH complex-mediated modulation of bacterial growth
NV Simwela, L Johnston, PP Bitar, E Jaecklein, C Altier, CM Sassetti, ...
Nature Communications 15 (1), 9322, 2024
22024
How macrophage heterogeneity affects tuberculosis disease and therapy
DG Russell, NV Simwela, JT Mattila, JA Flynn, HC Mwandumba, D Pisu
Nature Reviews Immunology, 1-15, 2025
12025
Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis
NV Simwela, E Jaecklein, CM Sassetti, DG Russell
bioRxiv, 2024
12024
A conserved metabolic signature associated with response to fast-acting anti-malarial agents
NV Simwela, WA Guiguemde, J Straimer, C Regnault, BH Stokes, ...
Microbiology spectrum 11 (6), e03976-22, 2023
12023
Drug action and resistance in malaria parasites: experimental genetics models and biochemical features of fast acting novel antimalarials
NV Simwela
University of Glasgow, 2020
2020
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Artiklar 1–13