| Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress J Tsoi, L Robert, K Paraiso, C Galvan, KM Sheu, J Lay, DJL Wong, M Atefi, ... Cancer cell 33 (5), 890-904. e5, 2018 | 796 | 2018 |
| Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage JW Park, JK Lee, KM Sheu, L Wang, NG Balanis, K Nguyen, BA Smith, ... Science 362 (6410), 91-95, 2018 | 289 | 2018 |
| Single cell multi-omics technology: methodology and application Y Hu, Q An, K Sheu, B Trejo, S Fan, Y Guo Frontiers in cell and developmental biology 6, 28, 2018 | 185 | 2018 |
| Pan-cancer convergence to a small-cell neuroendocrine phenotype that shares susceptibilities with hematological malignancies NG Balanis, KM Sheu, FN Esedebe, SJ Patel, BA Smith, JW Park, ... Cancer cell 36 (1), 17-34. e7, 2019 | 149 | 2019 |
| NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages QJ Cheng, S Ohta, KM Sheu, R Spreafico, A Adelaja, B Taylor, ... Science 372 (6548), 1349-1353, 2021 | 128 | 2021 |
| A human adult stem cell signature marks aggressive variants across epithelial cancers BA Smith, NG Balanis, A Nanjundiah, KM Sheu, BL Tsai, Q Zhang, ... Cell reports 24 (12), 3353-3366. e5, 2018 | 111 | 2018 |
| Functional hallmarks of healthy macrophage responses: their regulatory basis and disease relevance KM Sheu, A Hoffmann Annual review of immunology 40 (1), 295-321, 2022 | 93 | 2022 |
| Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses A Adelaja, B Taylor, KM Sheu, Y Liu, S Luecke, A Hoffmann Immunity 54 (5), 916-930. e7, 2021 | 92 | 2021 |
| Gene regulatory strategies that decode the duration of NFκB dynamics contribute to LPS-versus TNF-specific gene expression S Sen, Z Cheng, KM Sheu, YH Chen, A Hoffmann Cell systems 10 (2), 169-182. e5, 2020 | 66 | 2020 |
| Melanoma dedifferentiation induced by IFN-γ epigenetic remodeling in response to anti–PD-1 therapy YJ Kim, KM Sheu, J Tsoi, G Abril-Rodriguez, E Medina, CS Grasso, ... The Journal of clinical investigation 131 (12), 2021 | 52 | 2021 |
| Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation CC Chen, W Tran, K Song, T Sugimoto, MB Obusan, L Wang, KM Sheu, ... Cancer Cell 41 (12), 2066-2082. e9, 2023 | 35 | 2023 |
| Stimulus-specific responses in innate immunity: Multilayered regulatory circuits S Luecke, KM Sheu, A Hoffmann Immunity 54 (9), 1915-1932, 2021 | 33 | 2021 |
| Pathogenic TNF-α drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity Y Wang, L Guo, X Yin, EC McCarthy, MI Cheng, AT Hoang, HC Chen, ... Proceedings of the National Academy of Sciences 119 (4), e2114406119, 2022 | 32 | 2022 |
| Stimulus-specificity in the responses of immune sentinel cells KM Sheu, S Luecke, A Hoffmann Current opinion in systems biology 18, 53-61, 2019 | 22 | 2019 |
| Single-cell RNA cap and tail sequencing (scRCAT-seq) reveals subtype-specific isoforms differing in transcript demarcation Y Hu, J Zhong, Y Xiao, Z Xing, K Sheu, S Fan, Q An, Y Qiu, Y Zheng, X Liu, ... Nature communications 11 (1), 5148, 2020 | 20 | 2020 |
| Quantifying stimulus-response specificity to probe the functional state of macrophages KM Sheu, AA Guru, A Hoffmann Cell systems 14 (3), 180-195. e5, 2023 | 13 | 2023 |
| Stochastic models of nucleosome dynamics reveal regulatory rules of stimulus-induced epigenome remodeling J Kim, KM Sheu, QJ Cheng, A Hoffmann, G Enciso Cell reports 40 (2), 2022 | 6 | 2022 |
| Single-cell stimulus-response gene expression trajectories reveal the stimulus specificities of dynamic responses by single macrophages KM Sheu, A Pimplaskar, A Hoffmann Molecular Cell 84 (21), 4095-4110. e6, 2024 | 2 | 2024 |
| Dynamical and combinatorial coding by MAPK p38 and NFκB in the inflammatory response of macrophages S Luecke, X Guo, KM Sheu, A Singh, SC Lowe, M Han, J Diaz, F Lopes, ... Molecular Systems Biology 20 (8), 898-932, 2024 | 1 | 2024 |
| Methods for treating small cell neuroendocrine and related cancers TG Graeber, NG Balanis, KM Sheu, ON Witte, F ESEDEBE, JW PARK US Patent App. 17/613,881, 2022 | 1 | 2022 |
Thomas G. GraeberUCLAVerifierad e-postadress på mednet.ucla.edu