| Rewiring carbon metabolism in yeast for high level production of aromatic chemicals Q Liu, T Yu, X Li, Y Chen, K Campbell, J Nielsen, Y Chen Nature communications 10 (1), 4976, 2019 | 280 | 2019 |
| Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism J Zhang, SD Petersen, T Radivojevic, A Ramirez, A Pérez-Manríquez, ... Nature communications 11 (1), 4880, 2020 | 247 | 2020 |
| Deep learning-based kcat prediction enables improved enzyme-constrained model reconstruction F Li, L Yuan, H Lu, G Li, Y Chen, MKM Engqvist, EJ Kerkhoven, J Nielsen Nature Catalysis 5 (8), 662-672, 2022 | 228 | 2022 |
| Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast R Chen, J Gao, W Yu, X Chen, X Zhai, Y Chen, L Zhang, YJ Zhou Nature Chemical Biology 18 (5), 520-529, 2022 | 136 | 2022 |
| Energy metabolism controls phenotypes by protein efficiency and allocation Y Chen, J Nielsen Proceedings of the National Academy of Sciences 116 (35), 17592-17597, 2019 | 129 | 2019 |
| Proteome allocations change linearly with the specific growth rate of Saccharomyces cerevisiae under glucose limitation J Xia, BJ Sánchez, Y Chen, K Campbell, S Kasvandik, J Nielsen Nature Communications 13 (1), 2819, 2022 | 58 | 2022 |
| Engineering yeast for high-level production of diterpenoid sclareol X Cao, W Yu, Y Chen, S Yang, ZK Zhao, J Nielsen, H Luan, YJ Zhou Metabolic engineering 75, 19-28, 2023 | 55 | 2023 |
| Genome-scale modeling of yeast metabolism: retrospectives and perspectives Y Chen, F Li, J Nielsen FEMS Yeast Research 22 (1), foac003, 2022 | 51 | 2022 |
| Mathematical modeling of proteome constraints within metabolism Y Chen, J Nielsen Current Opinion in Systems Biology 25, 50-56, 2021 | 47 | 2021 |
| Improving recombinant protein production by yeast through genome-scale modeling using proteome constraints F Li, Y Chen, Q Qi, Y Wang, L Yuan, M Huang, IE Elsemman, A Feizi, ... Nature communications 13 (1), 2969, 2022 | 41 | 2022 |
| GotEnzymes: an extensive database of enzyme parameter predictions F Li, Y Chen, M Anton, J Nielsen Nucleic Acids Research 51 (D1), D583-D586, 2023 | 38 | 2023 |
| Engineering yeast metabolism for the discovery and production of polyamines and polyamine analogues J Qin, A Krivoruchko, B Ji, Y Chen, M Kristensen, E Özdemir, JD Keasling, ... Nature Catalysis 4 (6), 498-509, 2021 | 38 | 2021 |
| In vitro turnover numbers do not reflect in vivo activities of yeast enzymes Y Chen, J Nielsen Proceedings of the National Academy of Sciences 118 (32), e2108391118, 2021 | 35 | 2021 |
| Yeast optimizes metal utilization based on metabolic network and enzyme kinetics Y Chen, F Li, J Mao, Y Chen, J Nielsen Proceedings of the National Academy of Sciences 118 (12), e2020154118, 2021 | 35 | 2021 |
| Proteome constraints reveal targets for improving microbial fitness in nutrient‐rich environments Y Chen, E van Pelt‐KleinJan, B van Olst, S Douwenga, S Boeren, ... Molecular Systems Biology 17 (4), e10093, 2021 | 33 | 2021 |
| Flux control through protein phosphorylation in yeast Y Chen, J Nielsen FEMS yeast research 16 (8), 2016 | 33 | 2016 |
| Reconstruction, simulation and analysis of enzyme-constrained metabolic models using GECKO Toolbox 3.0 Y Chen, J Gustafsson, A Tafur Rangel, M Anton, I Domenzain, ... Nature Protocols 19 (3), 629-667, 2024 | 31 | 2024 |
| Yeast metabolic innovations emerged via expanded metabolic network and gene positive selection H Lu, F Li, L Yuan, I Domenzain, R Yu, H Wang, G Li, Y Chen, B Ji, ... Molecular Systems Biology 17 (10), e10427, 2021 | 28 | 2021 |
| Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast N Qin, L Li, X Ji, R Pereira, Y Chen, S Yin, C Li, X Wan, D Qiu, J Jiang, ... Cell 186 (4), 748-763. e15, 2023 | 24 | 2023 |
| Yeast has evolved to minimize protein resource cost for synthesizing amino acids Y Chen, J Nielsen Proceedings of the National Academy of Sciences 119 (4), e2114622119, 2022 | 24 | 2022 |
Jens NielsenProfessor in Systems Biology, Chalmers University of Technology, SwedenVerifierad e-postadress på chalmers.se