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Kathryn A. Whitehead
Kathryn A. Whitehead
Professor of Chemical Engineering, Carnegie Mellon University
Verifierad e-postadress på cmu.edu - Startsida
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Knocking down barriers: advances in siRNA delivery
KA Whitehead, R Langer, DG Anderson
Nature Reviews Drug Discovery 8 (2), 129-138, 2009
37572009
Lipid-like materials for low-dose, in vivo gene silencing
KT Love, KP Mahon, CG Levins, KA Whitehead, W Querbes, JR Dorkin, ...
Proceedings of the National Academy of Sciences 107 (5), 1864-1869, 2010
11362010
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
N Chaudhary, D Weissman, KA Whitehead
Nature reviews Drug discovery 20 (11), 817-838, 2021
10732021
Tools for translation: non-viral materials for therapeutic mRNA delivery
KA Hajj, KA Whitehead
Nature Reviews Materials 2 (10), 1-17, 2017
7282017
Managing diabetes with nanomedicine: challenges and opportunities
O Veiseh, BC Tang, KA Whitehead, DG Anderson, R Langer
Nature Reviews Drug Discovery 14 (1), 45-57, 2015
6472015
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
KA Whitehead, JR Dorkin, AJ Vegas, PH Chang, O Veiseh, J Matthews, ...
Nature communications 5 (1), 4277, 2014
5882014
Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation
D Chen, KT Love, Y Chen, AA Eltoukhy, C Kastrup, G Sahay, A Jeon, ...
Journal of the American Chemical Society 134 (16), 6948-6951, 2012
5582012
Materials for oral delivery of proteins and peptides
TD Brown, KA Whitehead, S Mitragotri
Nature Reviews Materials 5 (2), 127-148, 2020
4342020
Action and reaction: the biological response to siRNA and its delivery vehicles
RL Kanasty, KA Whitehead, AJ Vegas, DG Anderson
Molecular Therapy 20 (3), 513-524, 2012
3372012
Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization
RL Ball, P Bajaj, KA Whitehead
International journal of nanomedicine, 305-315, 2017
2902017
Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery
DJ Siegwart, KA Whitehead, L Nuhn, G Sahay, H Cheng, S Jiang, M Ma, ...
Proceedings of the National Academy of Sciences 108 (32), 12996-13001, 2011
2742011
Lipid nanoparticle formulations for enhanced co-delivery of siRNA and mRNA
RL Ball, KA Hajj, J Vizelman, P Bajaj, KA Whitehead
Nano letters 18 (6), 3814-3822, 2018
2672018
Silencing or stimulation? siRNA delivery and the immune system
KA Whitehead, JE Dahlman, RS Langer, DG Anderson
Annual review of chemical and biomolecular engineering 2 (1), 77-96, 2011
2652011
Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability
NG Lamson, A Berger, KC Fein, KA Whitehead
Nature biomedical engineering 4 (1), 84-96, 2020
2502020
Branched‐tail lipid nanoparticles potently deliver mRNA in vivo due to enhanced ionization at endosomal pH
KA Hajj, RL Ball, SB Deluty, SR Singh, D Strelkova, CM Knapp, ...
Small 15 (6), 1805097, 2019
2492019
Aminoalcohol lipidoids and uses thereof
KP Mahon, KT Love, CG Levins, KA Whitehead, RS Langer, DG Anderson
US Patent 8,450,298, 2013
2042013
Oral delivery of macromolecules using intestinal patches: applications for insulin delivery
K Whitehead, Z Shen, S Mitragotri
Journal of controlled release 98 (1), 37-45, 2004
1782004
Safe and effective permeation enhancers for oral drug delivery
K Whitehead, N Karr, S Mitragotri
Pharmaceutical research 25, 1782-1788, 2008
1742008
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs
ST LoPresti, ML Arral, N Chaudhary, KA Whitehead
Journal of Controlled Release 345, 819-831, 2022
1702022
Advances in drug delivery
BP Timko, K Whitehead, W Gao, DS Kohane, O Farokhzad, D Anderson, ...
Annual Review of Materials Research 41 (1), 1-20, 2011
1632011
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Artiklar 1–20