| Immune checkpoint signaling and cancer immunotherapy X He, C Xu Cell research 30 (8), 660-669, 2020 | 1044 | 2020 |
| Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism W Yang, Y Bai, Y Xiong, J Zhang, S Chen, X Zheng, X Meng, L Li, J Wang, ... Nature 531 (7596), 651-655, 2016 | 892 | 2016 |
| Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities B Huang, B Song, C Xu Nature metabolism 2 (2), 132-141, 2020 | 656 | 2020 |
| Regulation of T cell receptor activation by dynamic membrane binding of the CD3ɛ cytoplasmic tyrosine-based motif C Xu, E Gagnon, ME Call, JR Schnell, CD Schwieters, CV Carman, ... Cell 135 (4), 702-713, 2008 | 531 | 2008 |
| Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein KC O'Connor, KA McLaughlin, PL De Jager, T Chitnis, E Bettelli, C Xu, ... Nature medicine 13 (2), 211-217, 2007 | 453 | 2007 |
| Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids X Shi, Y Bi, W Yang, X Guo, Y Jiang, C Wan, L Li, Y Bai, J Guo, Y Wang, ... Nature 493 (7430), 111-115, 2013 | 294 | 2013 |
| The structure of the ζζ transmembrane dimer reveals features essential for its assembly with the T cell receptor ME Call, JR Schnell, C Xu, RA Lutz, JJ Chou, KW Wucherpfennig Cell 127 (2), 355-368, 2006 | 268 | 2006 |
| FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells X Meng, X Liu, X Guo, S Jiang, T Chen, Z Hu, H Liu, Y Bai, M Xue, R Hu, ... Nature 564 (7734), 130-135, 2018 | 243 | 2018 |
| Multiple signaling roles of CD3ε and its application in CAR-T cell therapy W Wu, Q Zhou, T Masubuchi, X Shi, H Li, X Xu, M Huang, L Meng, X He, ... Cell 182 (4), 855-871. e23, 2020 | 157 | 2020 |
| Chimeric antigen receptor designed to prevent ubiquitination and downregulation showed durable antitumor efficacy W Li, S Qiu, J Chen, S Jiang, W Chen, J Jiang, F Wang, W Si, Y Shu, ... Immunity 53 (2), 456-470. e6, 2020 | 144 | 2020 |
| Regulation of EGFR nanocluster formation by ionic protein-lipid interaction Y Wang, J Gao, X Guo, T Tong, X Shi, L Li, M Qi, Y Wang, M Cai, J Jiang, ... Cell research 24 (8), 959-976, 2014 | 141 | 2014 |
| Mechano-regulation of peptide-MHC class I conformations determines TCR antigen recognition P Wu, T Zhang, B Liu, P Fei, L Cui, R Qin, H Zhu, D Yao, RJ Martinez, ... Molecular cell 73 (5), 1015-1027. e7, 2019 | 129 | 2019 |
| Regulation of T cell signalling by membrane lipids W Wu, X Shi, C Xu Nature Reviews Immunology 16 (11), 690-701, 2016 | 125 | 2016 |
| Ionic protein–lipid interaction at the plasma membrane: what can the charge do? L Li, X Shi, X Guo, H Li, C Xu Trends in biochemical sciences 39 (3), 130-140, 2014 | 123 | 2014 |
| Ionic CD3− Lck interaction regulates the initiation of T-cell receptor signaling L Li, X Guo, X Shi, C Li, W Wu, C Yan, H Wang, H Li, C Xu Proceedings of the National Academy of Sciences 114 (29), E5891-E5899, 2017 | 108 | 2017 |
| The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1 PS Li, ZY Fu, YY Zhang, JH Zhang, CQ Xu, YT Ma, BL Li, BL Song Nature medicine 20 (1), 80-86, 2014 | 108 | 2014 |
| Cholesterol metabolism in T cells A Bietz, H Zhu, M Xue, C Xu Frontiers in immunology 8, 1664, 2017 | 88 | 2017 |
| Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity C Yan, L Zheng, S Jiang, H Yang, J Guo, L Jiang, T Li, H Zhang, Y Bai, ... Cancer Cell 41 (7), 1276-1293. e11, 2023 | 85 | 2023 |
| Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness J Chen, S Qiu, W Li, K Wang, Y Zhang, H Yang, B Liu, G Li, L Li, M Chen, ... Cell Research 33 (5), 341-354, 2023 | 79 | 2023 |
| Cbx4 regulates the proliferation of thymic epithelial cells and thymus function B Liu, YF Liu, YR Du, AN Mardaryev, W Yang, H Chen, ZM Xu, CQ Xu, ... Development 140 (4), 780-788, 2013 | 77 | 2013 |
Xiaoshan ShiSIAT CAS, UC Berkeley(2016-2021), SIBCB CAS(2009-2016), SJTU(2005-2009)Verifierad e-postadress på siat.ac.cn
