Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity M Hoffmann, H Hofmann-Winkler, JC Smith, N Krüger, P Arora, ... EBioMedicine 65, 2021 | 352 | 2021 |
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP KL Jønsson, A Laustsen, C Krapp, KA Skipper, K Thavachelvam, D Hotter, ... Nature communications 8 (1), 14391, 2017 | 318 | 2017 |
Sort1, encoded by the cardiovascular risk locus 1p13. 3, is a regulator of hepatic lipoprotein export M Kjolby, OM Andersen, T Breiderhoff, AW Fjorback, KM Pedersen, ... Cell metabolism 12 (3), 213-223, 2010 | 317 | 2010 |
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles C Goettsch, JD Hutcheson, M Aikawa, H Iwata, T Pham, A Nykjaer, ... The Journal of clinical investigation 126 (4), 1323-1336, 2016 | 245 | 2016 |
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling CB Vaegter, P Jansen, AW Fjorback, S Glerup, S Skeldal, M Kjolby, ... Nature neuroscience 14 (1), 54-61, 2011 | 223 | 2011 |
The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion C Gustafsen, M Kjolby, M Nyegaard, M Mattheisen, J Lundhede, ... Cell metabolism 19 (2), 310-318, 2014 | 199 | 2014 |
Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial. JD Gunst, NB Staerke, MH Pahus, LH Kristensen, J Bodilsen, N Lohse, ... EClinicalMedicine 35, 2021 | 177 | 2021 |
Diverse cellular architecture of atherosclerotic plaque derives from clonal expansion of a few medial SMCs K Jacobsen, MB Lund, J Shim, S Gunnersen, EM Füchtbauer, M Kjolby, ... JCI insight 2 (19), e95890, 2017 | 161 | 2017 |
Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis MB Mortensen, M Kjolby, S Gunnersen, JV Larsen, J Palmfeldt, E Falk, ... The Journal of clinical investigation 124 (12), 5317-5322, 2014 | 153 | 2014 |
Camostat mesylate against SARS‐CoV‐2 and COVID‐19—Rationale, dosing and safety P Breining, AL Frølund, JF Højen, JD Gunst, NB Staerke, E Saedder, ... Basic & clinical pharmacology & toxicology 128 (2), 204-212, 2021 | 150 | 2021 |
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification C Goettsch, JD Hutcheson, S Hagita, MA Rogers, MD Creager, T Pham, ... Atherosclerosis 251, 109-118, 2016 | 139 | 2016 |
Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study C Pottier, X Zhou, RB Perkerson, M Baker, GD Jenkins, DJ Serie, ... The Lancet Neurology 17 (6), 548-558, 2018 | 129 | 2018 |
Sortilin and its multiple roles in cardiovascular and metabolic diseases C Goettsch, M Kjolby, E Aikawa Arteriosclerosis, thrombosis, and vascular biology 38 (1), 19-25, 2018 | 129 | 2018 |
Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption A Etzerodt, M Kjolby, MJ Nielsen, M Maniecki, P Svendsen, SK Moestrup Antioxidants & redox signaling 18 (17), 2254-2263, 2013 | 106 | 2013 |
SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia S Glerup, D Olsen, CB Vaegter, C Gustafsen, SS Sjoegaard, G Hermey, ... Neuron 82 (5), 1074-1087, 2014 | 100 | 2014 |
SorCS2 is required for BDNF-dependent plasticity in the hippocampus S Glerup, U Bolcho, S Mølgaard, S Bøggild, CB Vaegter, AH Smith, ... Molecular Psychiatry 21 (12), 1740-1751, 2016 | 99 | 2016 |
Sortilin, encoded by the cardiovascular risk gene SORT1, and its suggested functions in cardiovascular disease M Kjolby, MS Nielsen, CM Petersen Current atherosclerosis reports 17, 1-9, 2015 | 97 | 2015 |
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection RM van der Sluis, LB Cham, A Gris‐Oliver, KR Gammelgaard, ... The EMBO journal 41 (10), e109622, 2022 | 79 | 2022 |
Volume natriuresis vs. pressure natriuresis P Bie, S Wamberg, M Kjolby Acta physiologica scandinavica 181 (4), 495-503, 2004 | 74 | 2004 |
SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET S Glerup, M Lume, D Olsen, JR Nyengaard, CB Vaegter, C Gustafsen, ... Cell reports 3 (1), 186-199, 2013 | 72 | 2013 |