| Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration C Metcalfe, NM Kljavin, R Ybarra, FJ de Sauvage Cell stem cell 14 (2), 149-159, 2014 | 580 | 2014 |
| Dynamic recruitment of axin by Dishevelled protein assemblies T Schwarz-Romond, C Metcalfe, M Bienz Journal of cell science 120 (14), 2402-2412, 2007 | 294 | 2007 |
| Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function EE Storm, S Durinck, F de Sousa E Melo, J Tremayne, N Kljavin, C Tan, ... Nature 529 (7584), 97-100, 2016 | 255 | 2016 |
| Inhibition of GSK3 by Wnt signalling–two contrasting models C Metcalfe, M Bienz Journal of cell science 124 (21), 3537-3544, 2011 | 228 | 2011 |
| Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists C Metcalfe, FJ de Sauvage Cancer research 71 (15), 5057-5061, 2011 | 214 | 2011 |
| Therapeutic ligands antagonize estrogen receptor function by impairing its mobility J Guan, W Zhou, M Hafner, RA Blake, C Chalouni, IP Chen, T De Bruyn, ... Cell 178 (4), 949-963. e18, 2019 | 185 | 2019 |
| The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer JD Joseph, B Darimont, W Zhou, A Arrazate, A Young, E Ingalla, K Walter, ... Elife 5, e15828, 2016 | 137 | 2016 |
| GDC-9545 (Giredestrant): a potent and orally bioavailable selective estrogen receptor antagonist and degrader with an exceptional preclinical profile for ER+ breast cancer J Liang, JR Zbieg, RA Blake, JH Chang, S Daly, AG DiPasquale, ... Journal of Medicinal Chemistry 64 (16), 11841-11856, 2021 | 117 | 2021 |
| Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization C Metcalfe, C Mendoza-Topaz, J Mieszczanek, M Bienz Journal of cell science 123 (9), 1588-1599, 2010 | 117 | 2010 |
| Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer MR Junttila, V Devasthali, JH Cheng, J Castillo, C Metcalfe, AC Clermont, ... Molecular cancer therapeutics 14 (1), 40-47, 2015 | 66 | 2015 |
| Latest generation estrogen receptor degraders for the treatment of hormone receptor-positive breast cancer YC Chen, J Yu, C Metcalfe, T De Bruyn, T Gelzleichter, V Malhi, ... Expert opinion on investigational drugs 31 (6), 515-529, 2022 | 64 | 2022 |
| PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition C Metcalfe, B Alicke, A Crow, M Lamoureux, GJP Dijkgraaf, F Peale, ... Cancer research 73 (23), 7034-7042, 2013 | 62 | 2013 |
| Therapeutic resistance to anti-oestrogen therapy in breast cancer M Will, J Liang, C Metcalfe, S Chandarlapaty Nature Reviews Cancer 23 (10), 673-685, 2023 | 60 | 2023 |
| Dvl2 Promotes Intestinal Length and Neoplasia in the ApcMin Mouse Model for Colorectal Cancer C Metcalfe, AEK Ibrahim, M Graeb, M de la Roche, T Schwarz-Romond, ... Cancer research 70 (16), 6629-6638, 2010 | 59 | 2010 |
| Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice NVJA Büller, SL Rosekrans, C Metcalfe, J Heijmans, WA Van Dop, ... Gastroenterology 148 (1), 170-180. e6, 2015 | 43 | 2015 |
| Compressive stress-mediated p38 activation required for ERα+ phenotype in breast cancer PM Munne, L Martikainen, I Räty, K Bertula, Nonappa, J Ruuska, ... Nature communications 12 (1), 6967, 2021 | 37 | 2021 |
| Abstract PD5-10: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-0927, in postmenopausal women with estrogen receptor … MN Dickler, R Villanueva, JA Perez Fidalgo, IA Mayer, V Boni, EP Winer, ... Cancer research 78 (4_Supplement), PD5-10-PD5-10, 2018 | 33 | 2018 |
| A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-9545, in postmenopausal women with estrogen receptor-positive (ER+) HER2 … K Jhaveri, EP Winer, E Lim, JA Perez Fidalgo, M Bellet, IA Mayer, V Boni, ... Reason 1, 3, 2020 | 29 | 2020 |
| Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes C Metcalfe, E Ingalla, RA Blake, J Chang, A Daemen, T De Bruyn, ... Cancer Research 79 (4_Supplement), P5-04-07-P5-04-07, 2019 | 28 | 2019 |
| Discovery of GNE-149 as a full antagonist and efficient degrader of estrogen receptor alpha for ER+ breast cancer J Liang, R Blake, J Chang, LS Friedman, S Goodacre, S Hartman, ... ACS medicinal chemistry letters 11 (6), 1342-1347, 2020 | 27 | 2020 |
Gijs van den BrinkProfessor of Experimental GastroenterologyVerifierad e-postadress på amc.nl