| Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3 HB Kamadurai, Y Qiu, A Deng, JS Harrison, C MacDonald, M Actis, ... Elife 2, e00828, 2013 | 210 | 2013 |
| Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon T Van Nguyen, JE Lee, MJ Sweredoski, SJ Yang, SJ Jeon, JS Harrison, ... Molecular Cell 61 (6), 809-820, 2016 | 175 | 2016 |
| Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C NG Brown, R VanderLinden, ER Watson, F Weissmann, A Ordureau, ... Cell 165 (6), 1440-1453, 2016 | 158 | 2016 |
| Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1 JS Harrison, EM Cornett, D Goldfarb, PA DaRosa, ZM Li, F Yan, ... eLife 5, e17101, 2016 | 149 | 2016 |
| An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1 ZM Zhang, SB Rothbart, DF Allison, Q Cai, JS Harrison, L Li, Y Wang, ... Cell reports 12 (9), 1400-1406, 2015 | 110 | 2015 |
| Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate KM Mulvaney, JP Matson, PF Siesser, TY Tamir, D Goldfarb, TM Jacobs, ... Journal of Biological Chemistry 291 (45), 23719-23733, 2016 | 83 | 2016 |
| A bifunctional role for the UHRF1 UBL domain in the control of hemi-methylated DNA-dependent histone ubiquitylation PA DaRosa, JS Harrison, A Zelter, TN Davis, P Brzovic, B Kuhlman, ... Molecular cell 72 (4), 753-765. e6, 2018 | 82 | 2018 |
| Inhibition of Ebola virus entry by a C-peptide targeted to endosomes EH Miller, JS Harrison, SR Radoshitzky, CD Higgins, X Chi, L Dong, ... Journal of Biological Chemistry 286 (18), 15854, 2011 | 81 | 2011 |
| Role of Electrostatic Repulsion in Controlling pH-Dependent Conformational Changes of Viral Fusion Proteins JS Harrison, CD Higgins, MJ O’Meara, JF Koellhoffer, BA Kuhlman, ... Structure 21 (7), 1085-1096, 2013 | 74 | 2013 |
| p62-dependent phase separation of patient-derived KEAP1 mutations and NRF2 EW Cloer, PF Siesser, EM Cousins, D Goldfarb, DD Mowrey, JS Harrison, ... Molecular and cellular biology 38 (22), e00644-17, 2018 | 68 | 2018 |
| Designed protein mimics of the Ebola virus glycoprotein GP2 α‐helical bundle: Stability and pH effects JS Harrison, CD Higgins, K Chandran, JR Lai Protein Science, 2011 | 59 | 2011 |
| Sulfite reduction in mycobacteria R Pinto, JS Harrison, T Hsu, WR Jacobs Jr, TS Leyh Journal of bacteriology 189 (18), 6714-6722, 2007 | 54 | 2007 |
| Crystal Structure of the Marburg Virus GP2 Core Domain in its Post-Fusion Conformation JF Koellhoffer, VN Malashkevich, JS Harrison, R Toro, RC Bhosle, ... Biochemistry, 2012 | 53 | 2012 |
| Marburg Virus Glycoprotein GP2: pH-Dependent Stability of the Ectodomain α-Helical Bundle JS Harrison, JF Koellhoffer, K Chandran, JR Lai Biochemistry, 2012 | 49 | 2012 |
| Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance RM Vaughan, BM Dickson, EM Cornett, JS Harrison, B Kuhlman, ... Nucleic acids research 46 (9), 4405-4416, 2018 | 36 | 2018 |
| Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler J Liwocha, DT Krist, G van der Heden van Noort, FM Hansen, VH Truong, ... Nature chemical biology 17 (3), 272-279, 2021 | 34 | 2021 |
| Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species JF Koellhoffer, Z Dai, VN Malashkevich, MD Stenglein, Y Liu, R Toro, ... Journal of molecular biology 426 (7), 1452-1468, 2014 | 32 | 2014 |
| Designed, highly expressing, thermostable dengue virus 2 envelope protein dimers elicit quaternary epitope antibodies ST Kudlacek, S Metz, D Thiono, AM Payne, TTN Phan, S Tian, ... Science Advances 7 (42), eabg4084, 2021 | 31 | 2021 |
| Contribution of Light Chain Residues to High Affinity Binding in an HIV-1 Antibody Explored by Combinatorial Scanning Mutagenesis GF Da Silva, JS Harrison, JR Lai Biochemistry 49 (26), 5464-5472, 2010 | 23 | 2010 |
| Identification of disease-linked hyperactivating mutations in UBE3A through large-scale functional variant analysis KP Weston, X Gao, J Zhao, KS Kim, SE Maloney, J Gotoff, S Parikh, ... Nature Communications 12 (1), 1-15, 2021 | 20 | 2021 |
Brian KuhlmanUniversity of North CarolinaVerifierad e-postadress på email.unc.edu