| Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic … U Eckhard, PF Huesgen, O Schilling, CL Bellac, GS Butler, JH Cox, ... Matrix biology 49, 37-60, 2016 | 228 | 2016 |
| Network analyses reveal pervasive functional regulation between proteases in the human protease web N Fortelny, JH Cox, R Kappelhoff, AE Starr, PF Lange, P Pavlidis, ... PLoS biology 12 (5), e1001869, 2014 | 183 | 2014 |
| The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human É Korpos, N Kadri, R Kappelhoff, J Wegner, CM Overall, E Weber, ... Diabetes 62 (2), 531-542, 2013 | 163 | 2013 |
| Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors CM Overall, EM Tam, R Kappelhoff, A Connor, T Ewart, CJ Morrison, ... Walter de Gruyter 385 (6), 493-504, 2004 | 162 | 2004 |
| Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates C Becker-Pauly, O Barré, O Schilling, U auf dem Keller, A Ohler, C Broder, ... Molecular & Cellular Proteomics 10 (9), 2011 | 145 | 2011 |
| Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis CL Bellac, A Dufour, MJ Krisinger, A Loonchanta, AE Starr, ... Cell Reports 9 (2), 618-632, 2014 | 110 | 2014 |
| Proenzyme structure and activation of astacin metallopeptidase T Guevara, I Yiallouros, R Kappelhoff, S Bissdorf, W Stöcker, ... Journal of Biological Chemistry 285 (18), 13958-13965, 2010 | 99 | 2010 |
| Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression JH Cox, AE Starr, R Kappelhoff, R Yan, CR Roberts, CM Overall Arthritis & Rheumatism 62 (12), 3645-3655, 2010 | 98 | 2010 |
| Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome I Pablos, Y Machado, HCR de Jesus, Y Mohamud, R Kappelhoff, ... Cell reports 37 (4), 2021 | 94 | 2021 |
| C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease A Dufour, CL Bellac, U Eckhard, N Solis, T Klein, R Kappelhoff, N Fortelny, ... Nature Communications 9 (1), 2416, 2018 | 84 | 2018 |
| Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis C Morrison, S Mancini, J Cipollone, R Kappelhoff, C Roskelley, C Overall Journal of Biological Chemistry 286 (39), 34271-34285, 2011 | 83 | 2011 |
| Novel matrix metalloproteinase inhibitor [18F] marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer U auf dem Keller, CL Bellac, Y Li, Y Lou, PF Lange, R Ting, C Harwig, ... Cancer research 70 (19), 7562-7569, 2010 | 81 | 2010 |
| Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries O Barre, A Dufour, U Eckhard, R Kappelhoff, F Beliveau, R Leduc, ... PloS one 9 (9), e105984, 2014 | 71 | 2014 |
| Activation mechanism of pro-astacin: role of the pro-peptide, tryptic and autoproteolytic cleavage and importance of precise amino-terminal processing I Yiallouros, R Kappelhoff, O Schilling, F Wegmann, MW Helms, A Auge, ... Journal of molecular biology 324 (2), 237-246, 2002 | 63 | 2002 |
| Overview of transcriptomic analysis of all human proteases, non-proteolytic homologs and inhibitors: organ, tissue and ovarian cancer cell line expression profiling of the … R Kappelhoff, XS Puente, CH Wilson, A Seth, C Lopez-Otin, CM Overall Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1864 (11), 2210-2219, 2017 | 50 | 2017 |
| Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14 U Eckhard, PF Huesgen, O Schilling, CL Bellac, GS Butler, JH Cox, ... Data in brief 7, 299-310, 2016 | 31 | 2016 |
| Repression of Salmonella enterica phoP Expression by Small Molecules from Physiological Bile LCM Antunes, M Wang, SK Andersen, RBR Ferreira, R Kappelhoff, J Han, ... Journal of bacteriology 194 (9), 2286-2296, 2012 | 28 | 2012 |
| Novel grooved substrata stimulate macrophage fusion, CCL2 and MMP‐9 secretion H Moon, CVM Cremmel, A Kulpa, NAF Jaeger, R Kappelhoff, CM Overall, ... Journal of Biomedical Materials Research Part A 104 (9), 2243-2254, 2016 | 20 | 2016 |
| Persistent Salmonella enterica Serovar Typhimurium Infection Induces Protease Expression During Intestinal Fibrosis K Ehrhardt, N Steck, R Kappelhoff, S Stein, F Rieder, IO Gordon, EC Boyle, ... Inflammatory Bowel Diseases 25 (10), 1629-1643, 2019 | 19 | 2019 |
| The CLIP‐CHIP oligonucleotide microarray: dedicated array for analysis of all protease, nonproteolytic homolog, and inhibitor gene transcripts in human and mouse R Kappelhoff, C Overall Current protocols in protein science 56 (1), 21.19. 1-21.19. 16, 2009 | 16 | 2009 |
Christopher M OverallUniversity of British ColumbiaVerifierad e-postadress på ubc.ca
