Hyperekplexia associated with compound heterozygote mutations in the β-subunit of the human inhibitory glycine receptor (GLRB) MI Rees, TM Lewis, JBJ Kwok, GR Mortier, P Govaert, RG Snell, ... Human molecular genetics 11 (7), 853-860, 2002 | 195 | 2002 |
Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single‐channel behaviour. LG Sivilotti, DK McNeil, TM Lewis, MA Nassar, R Schoepfer, D Colquhoun The Journal of Physiology 500 (1), 123-138, 1997 | 160 | 1997 |
The ion channel properties of a rat recombinant neuronal nicotinic receptor are dependent on the host cell type. TM Lewis, PC Harkness, LG Sivilotti, D Colquhoun, NS Millar The Journal of Physiology 505 (Pt 2), 299-306, 1997 | 138 | 1997 |
Properties of human glycine receptors containing the hyperekplexia mutation α1 (K276E), expressed in Xenopus oocytes TM Lewis, LG Sivilotti, D Colquhoun, RM Gardiner, R Schoepfer, M Rees The Journal of physiology 507 (1), 25-40, 1998 | 119 | 1998 |
Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor NL Absalom, TM Lewis, W Kaplan, KD Pierce, PR Schofield Journal of Biological Chemistry 278 (50), 50151-50157, 2003 | 107 | 2003 |
Compound heterozygosity and nonsense mutations in the α1-subunit of the inhibitory glycine receptor in hyperekplexia MI Rees, TM Lewis, B Vafa, C Ferrie, P Corry, F Muntoni, H Jungbluth, ... Human genetics 109 (3), 267-270, 2001 | 93 | 2001 |
Mechanisms of channel gating of the ligand‐gated ion channel superfamily inferred from protein structure NL Absalom, TM Lewis, PR Schofield Experimental physiology 89 (2), 145-153, 2004 | 76 | 2004 |
Characterization of the effects of charged residues in the intracellular loop on ion permeation in α1 glycine receptor channels JE Carland, MA Cooper, S Sugiharto, HJ Jeong, TM Lewis, PH Barry, ... Journal of Biological Chemistry 284 (4), 2023-2030, 2009 | 69 | 2009 |
Gating mechanisms in Cys-loop receptors JME Cederholm, PR Schofield, TM Lewis European Biophysics Journal 39 (1), 37-49, 2009 | 63 | 2009 |
Kinetic determinants of agonist action at the recombinant human glycine receptor TM Lewis, PR Schofield, AML McClellan The Journal of physiology 549 (2), 361-374, 2003 | 61 | 2003 |
Identification of a new ligand binding domain in the alpha1 subunit of the inhibitory glycine receptor. B Vafa, TM Lewis, AM Cunningham, P Jacques, JW Lynch, PR Schofield Journal of neurochemistry 73 (5), 2158-2166, 1999 | 46 | 1999 |
Pore structure of the Cys-loop ligand-gated ion channels NL Absalom, PR Schofield, TM Lewis Neurochemical research 34 (10), 1805-1815, 2009 | 34 | 2009 |
Anion-cation permeability correlates with hydrated counterion size in glycine receptor channels S Sugiharto, TM Lewis, AJ Moorhouse, PR Schofield, PH Barry Biophysical journal 95 (10), 4698-4715, 2008 | 31 | 2008 |
Immunolabelling for VDAC, the mitochondrial voltage-dependent anion channel, on sarcoplasmic reticulum from amphibian skeletal muscle TM Lewis, ML Roberts, AH Bretag Neuroscience letters 181 (1-2), 83-86, 1994 | 25 | 1994 |
Covalent Trapping of Methyllycaconitine at the α4-α4 Interface of the α4β2 Nicotinic Acetylcholine Receptor ANTAGONIST BINDING SITE AND MODE OF RECEPTOR INHIBITION REVEALED NL Absalom, G Quek, TM Lewis, T Qudah, I von Arenstorff, JI Ambrus, ... Journal of Biological Chemistry 288 (37), 26521-26532, 2013 | 22 | 2013 |
An optimised 3 M KCl salt-bridge technique used to measure and validate theoretical liquid junction potential values in patch-clamping and electrophysiology PH Barry, TM Lewis, AJ Moorhouse European Biophysics Journal 42 (8), 631-646, 2013 | 19 | 2013 |
Mixed antagonistic effects of the ginkgolides at recombinant human ρ< sub> 1</sub> GABA< sub> C</sub> receptors SH Huang, TM Lewis, SCR Lummis, AJ Thompson, M Chebib, ... Neuropharmacology 63 (6), 1127-1139, 2012 | 14 | 2012 |
Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stochiometry DC Indurthi, T Qudah, VW Liao, PK Ahring, TM Lewis, T Balle, M Chebib, ... Pharmacological research 139, 215-227, 2019 | 13 | 2019 |
A single P-loop glutamate point mutation to either lysine or arginine switches the cation–anion selectivity of the CNGA2 channel W Qu, AJ Moorhouse, M Chandra, KD Pierce, TM Lewis, PH Barry The Journal of general physiology 127 (4), 375-389, 2006 | 13 | 2006 |
Structure‐Function Relationships of the Human Glycine Receptor: Insights from Hyperekplexia Mutations TM Lewis, PR Schofield Annals of the New York Academy of Sciences 868 (1), 681-684, 1999 | 13 | 1999 |