Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells A Hendel, RO Bak, JT Clark, AB Kennedy, DE Ryan, S Roy, I Steinfeld, ... Nature biotechnology 33 (9), 985-989, 2015 | 1274 | 2015 |
Quantifying genome-editing outcomes at endogenous loci with SMRT sequencing A Hendel, EJ Kildebeck, EJ Fine, JT Clark, N Punjya, V Sebastiano, ... Cell reports 7 (1), 293-305, 2014 | 149 | 2014 |
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection JA Perry, L Shallberg, JT Clark, JA Gullicksrud, JH DeLong, BB Douglas, ... Nature immunology 23 (5), 743-756, 2022 | 71 | 2022 |
The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses L Chen, DA Christian, JA Kochanowsky, AT Phan, JT Clark, S Wang, ... Journal of Experimental Medicine 217 (3), e20181757, 2020 | 63 | 2020 |
CRISPR/Cas9 genome engineering in engraftable human brain-derived neural stem cells DP Dever, SG Scharenberg, J Camarena, EJ Kildebeck, JT Clark, ... Iscience 15, 524-535, 2019 | 37 | 2019 |
The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host cell JE Dumaine, A Sateriale, AR Gibson, AG Reddy, JA Gullicksrud, ... Elife 10, e70451, 2021 | 34 | 2021 |
IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii JT Clark, DA Christian, JA Gullicksrud, JA Perry, J Park, M Jacquet, ... Elife 10, e65614, 2021 | 32 | 2021 |
cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory DA Christian, TA Adams, LA Shallberg, AT Phan, TE Smith, M Abraha, ... Science immunology 7 (75), eabq7432, 2022 | 27 | 2022 |
Chemically modified guide RNAs for CRISPR/CAS-mediated gene regulation MH Porteus, A Hendel, J Clark, RO Bak, DE Ryan, DJ Dellinger, R Kaiser, ... US Patent 11,306,309, 2022 | 21 | 2022 |
PD-1 and CTLA-4 exert additive control of effector regulatory T cells at homeostasis JA Perry, Z Lanzar, JT Clark, AP Hart, BB Douglas, L Shallberg, K O'Dea, ... Frontiers in Immunology 14, 818, 2023 | 11 | 2023 |
IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii JT Clark, OE Weizman, DL Aldridge, LA Shallberg, J Eberhard, Z Lanzar, ... Cell reports 42 (3), 2023 | 8 | 2023 |
PD-L1–PD-1 interactions limit effector Treg cell populations at homeostasis and during infection JA Perry, JT Clark, J Gullicksrud, J DeLong, L Shallberg, B Douglas, ... bioRxiv, 2020.12. 09.416990, 2020 | 1 | 2020 |
Genome editing of human neural stem cells using nucleases MH Porteus, EJ Kildebeck, DP Dever, JT Clark, A Tsukamoto, N Uchida US Patent App. 18/092,911, 2023 | | 2023 |
PD-1 and CTLA-4 exert additive control of effector regulatory T cells JA Perry, Z Lanzar, JT Clark, AP Hart, BB Douglas, L Shallberg, K O’Dea, ... bioRxiv, 2022.07. 22.501159, 2022 | | 2022 |
PD-1 LIMITS TREG IMMUNE SUPPRESSION DURING ACUTE TOXOPLASMOSIS J Perry, JT Clark, J Gullicksrud, J DeLong, L Shallberg, B Douglas, A Hart, ... AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 105 (5), 449-449, 2021 | | 2021 |
Understanding the Role of the IL-1 Family Cytokines IL-18 and IL-33 in Protective and Pathological Responses to Toxoplasma gondii JT Clark University of Pennsylvania, 2021 | | 2021 |
PD-1 signaling impacts T cell function during the early phase of infection with Toxoplasma gondii JA Perry, J Delong, J Clark, J Park, J Gullicksrud, L Shallberg, C Konradt, ... The Journal of Immunology 202 (1_Supplement), 122.5-122.5, 2019 | | 2019 |
IL-33 potentiates the inflammatory response to Toxoplasma gondii JT Clark, J Park, C Konradt, M Jacquet, C Hunter CYTOKINE 100, 46-46, 2017 | | 2017 |
Chemically synthesized modified guide RNAs enhance CRISPR/cas9 genome editing J Myerson, AB Kennedy, DE Ryan, SM Phadnis, CW Yung, RO Bak, ... Synthetic Biology: Engineering, Evolution, and Design Conference 2016, SEED …, 2016 | | 2016 |