Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics D Smirlis, R Muangmoonchai, M Edwards, IR Phillips, EA Shephard Journal of Biological Chemistry 276 (16), 12822-12826, 2001 | 146 | 2001 |
Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death D Smirlis, M Duszenko, AJ Ruiz, E Scoulica, P Bastien, N Fasel, ... Parasites & vectors 3, 1-15, 2010 | 138 | 2010 |
Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC … R MUANGMOONCHAI, D SMIRLIS, SC WONG, M EDWARDS, ... Biochemical Journal 355 (1), 71-78, 2001 | 123 | 2001 |
Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and … G Bussotti, E Gouzelou, M Côrtes Boité, I Kherachi, Z Harrat, N Eddaikra, ... MBio 9 (6), 10.1128/mbio. 01399-18, 2018 | 107 | 2018 |
6-Br-5methylindirubin-3′ oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like … E Xingi, D Smirlis, V Myrianthopoulos, P Magiatis, KM Grant, L Meijer, ... International journal for parasitology 39 (12), 1289-1303, 2009 | 98 | 2009 |
Low oxygen tension enhances hepatitis C virus replication N Vassilaki, KI Kalliampakou, I Kotta-Loizou, C Befani, P Liakos, G Simos, ... Journal of virology 87 (5), 2935-2948, 2013 | 65 | 2013 |
Anti-Trypanosoma cruzi activity of nicotinamide MBP Soares, CV Silva, TM Bastos, ET Guimarães, CP Figueira, D Smirlis, ... Acta tropica 122 (2), 224-229, 2012 | 58 | 2012 |
Vaccination with Leishmania histone H1-pulsed dendritic cells confers protection in murine visceral leishmaniasis M Agallou, D Smirlis, KP Soteriadou, E Karagouni Vaccine 30 (34), 5086-5093, 2012 | 54 | 2012 |
Antileishmanial activity of fucosterol recovered from Lessonia vadosa Searles (Lessoniaceae) by SFE, PSE and CPC M Becerra, S Boutefnouchet, O Córdoba, GP Vitorino, L Brehu, I Lamour, ... Phytochemistry Letters 11, 418-423, 2015 | 51 | 2015 |
Leishmania Protein Kinases: Important Regulators of the Parasite Life Cycle and Molecular Targets for Treating Leishmaniasis A Efstathiou, D Smirlis Microorganisms 9 (4), 691, 2021 | 47 | 2021 |
Genetic diversity and structure in Leishmania infantum populations from southeastern Europe revealed by microsatellite analysis E Gouzelou, C Haralambous, M Antoniou, V Christodoulou, F Martinković, ... Parasites & vectors 6, 1-19, 2013 | 47 | 2013 |
Transfection of liver in vivo by biolistic particle delivery: its use in the investigation of cytochrome P450 gene regulation R Muangmoonchai, SC Wong, D Smirlis, IR Phillips, EA Shephard Molecular biotechnology 20, 145-151, 2002 | 47 | 2002 |
An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3 A Efstathiou, N Gaboriaud-Kolar, D Smirlis, V Myrianthopoulos, ... Parasites & vectors 7, 1-12, 2014 | 44 | 2014 |
In vitro activity of 10-deacetylbaccatin III against Leishmania donovani promastigotes and intracellular amastigotes K Georgopoulou, D Smirlis, S Bisti, E Xingi, L Skaltsounis, K Soteriadou Planta medica 73 (10), 1081-1088, 2007 | 40 | 2007 |
Leishmania histone H1 overexpression delays parasite cell‐cycle progression, parasite differentiation and reduces Leishmania infectivity in vivo D Smirlis, SN Bisti, E Xingi, G Konidou, M Thiakaki, KP Soteriadou Molecular microbiology 60 (6), 1457-1473, 2006 | 39 | 2006 |
Leishmania donovani 90 kD Heat Shock Protein – Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity A Hombach-Barrigah, K Bartsch, D Smirlis, H Rosenqvist, A MacDonald, ... Scientific reports 9 (1), 5074, 2019 | 36 | 2019 |
Trypanosomatid apoptosis:'Apoptosis' without the canonical regulators D Smirlis, K Soteriadou Virulence 2 (3), 253-256, 2011 | 34 | 2011 |
Selection of molecular targets for drug development against trypanosomatids D Smirlis, MBP Soares Proteins and Proteomics of Leishmania and Trypanosoma, 43-76, 2013 | 26 | 2013 |
Induction of protective cellular immune responses against experimental visceral leishmaniasis mediated by dendritic cells pulsed with the N-terminal domain of Leishmania … M Agallou, E Pantazi, E Tsiftsaki, DK Toubanaki, C Gaitanaki, D Smirlis, ... Molecular Immunology 103, 7-20, 2018 | 23 | 2018 |
Benzo [a] pyrene-induced cell cycle arrest in HepG2 cells is associated with delayed induction of mitotic instability D Stellas, VL Souliotis, M Bekyrou, D Smirlis, M Kirsch-Volders, ... Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 769, 59-68, 2014 | 21 | 2014 |