T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions SP Schoenberger, REM Toes, EIH Van der Voort, R Offringa, CJM Melief Nature 393 (6684), 480-483, 1998 | 3374 | 1998 |
Genetics of rheumatoid arthritis contributes to biology and drug discovery Y Okada, D Wu, G Trynka, T Raj, C Terao, K Ikari, Y Kochi, K Ohmura, ... Nature 506 (7488), 376-381, 2014 | 2625 | 2014 |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci EA Stahl, S Raychaudhuri, EF Remmers, G Xie, S Eyre, BP Thomson, Y Li, ... Nature genetics 42 (6), 508-514, 2010 | 1620 | 2010 |
Synergism of cytotoxic T lymphocyte–associated antigen 4 blockade and depletion of CD25+ regulatory T cells in antitumor therapy reveals alternative pathways for suppression of … RPM Sutmuller, LM Van Duivenvoorde, A Van Elsas, TNM Schumacher, ... The Journal of experimental medicine 194 (6), 823-832, 2001 | 1319 | 2001 |
Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells J Wang, A Ioan‐Facsinay, EIH Van der Voort, TWJ Huizinga, REM Toes European journal of immunology 37 (1), 129-138, 2007 | 1304 | 2007 |
Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study FA Van Gaalen, SP Linn‐Rasker, WJ Van Venrooij, BA De Jong, ... Arthritis & Rheumatism 50 (3), 709-715, 2004 | 982 | 2004 |
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin U Harre, D Georgess, H Bang, A Bozec, R Axmann, E Ossipova, ... The Journal of clinical investigation 122 (5), 1791-1802, 2012 | 907 | 2012 |
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA–DRB1 shared epitope for antibodies to citrullinated proteins TWJ Huizinga, CI Amos, AHM van der Helm‐van Mil, W Chen, ... Arthritis & Rheumatism 52 (11), 3433-3438, 2005 | 813 | 2005 |
Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review BJE De Lange-Brokaar, A Ioan-Facsinay, GJVM Van Osch, AM Zuurmond, ... Osteoarthritis and cartilage 20 (12), 1484-1499, 2012 | 793 | 2012 |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis S Eyre, J Bowes, D Diogo, A Lee, A Barton, P Martin, A Zhernakova, ... Nature genetics 44 (12), 1336-1340, 2012 | 781 | 2012 |
Decreased tumor surveillance in perforin-deficient mice. ME van den Broek, D Kägi, F Ossendorp, R Toes, S Vamvakas, WK Lutz, ... The Journal of experimental medicine 184 (5), 1781-1790, 1996 | 771 | 1996 |
Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors F Ossendorp, E Mengedé, M Camps, R Filius, CJM Melief The Journal of experimental medicine 187 (5), 693, 1998 | 758 | 1998 |
Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage J Shi, R Knevel, P Suwannalai, MP van der Linden, GMC Janssen, ... Proceedings of the National Academy of Sciences 108 (42), 17372-17377, 2011 | 756 | 2011 |
Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis AHM van der Helm-van Mil, KN Verpoort, FC Breedveld, REM Toes, ... Arthritis research & therapy 7, 1-10, 2005 | 716 | 2005 |
CD4 T cells and their role in antitumor immune responses REM Toes, F Ossendorp, R Offringa, CJM Melief Journal of Experimental Medicine 189 (5), 753-756, 1999 | 658 | 1999 |
Expression of FOXP3 mRNA is not confined to CD4+ CD25+ T regulatory cells in humans ME Morgan, JHM van Bilsen, AM Bakker, B Heemskerk, MW Schilham, ... Human immunology 66 (1), 13-20, 2005 | 655 | 2005 |
Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis H Källberg, L Padyukov, RM Plenge, J Rönnelid, PK Gregersen, ... The American Journal of Human Genetics 80 (5), 867-875, 2007 | 629 | 2007 |
Common variants at CD40 and other loci confer risk of rheumatoid arthritis S Raychaudhuri, EF Remmers, AT Lee, R Hackett, C Guiducci, NP Burtt, ... Nature genetics 40 (10), 1216-1223, 2008 | 622 | 2008 |
CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy L Diehl, AT den Boer, SP Schoenberger, EIH van der Voort, ... Nature medicine 5 (7), 774-779, 1999 | 593 | 1999 |
Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double‐blind, randomized, placebo‐controlled trial H van Dongen, J van Aken, LR Lard, K Visser, HK Ronday, ... Arthritis & Rheumatism 56 (5), 1424-1432, 2007 | 559 | 2007 |