Spider-venom peptides as therapeutics NJ Saez, S Senff, JE Jensen, SY Er, V Herzig, LD Rash, GF King Toxins 2 (12), 2851-2871, 2010 | 359 | 2010 |
Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli JK Klint, S Senff, NJ Saez, R Seshadri, HY Lau, NS Bende, EAB Undheim, ... PloS one 8 (5), e63865, 2013 | 177 | 2013 |
Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation SH Hu, MP Christie, NJ Saez, CF Latham, R Jarrott, LHL Lua, BM Collins, ... Proceedings of the National Academy of Sciences 108 (3), 1040-1045, 2011 | 120 | 2011 |
ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins SS Pineda, PA Chaumeil, A Kunert, Q Kaas, MWC Thang, L Le, M Nuhn, ... Bioinformatics 34 (6), 1074-1076, 2018 | 118 | 2018 |
A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a NJ Saez, M Mobli, M Bieri, IR Chassagnon, AK Malde, R Gamsjaeger, ... Molecular pharmacology 80 (5), 796-808, 2011 | 106 | 2011 |
Versatile spider venom peptides and their medical and agricultural applications NJ Saez, V Herzig Toxicon 158, 109-126, 2019 | 87 | 2019 |
High throughput screening identifies disulfide isomerase DsbC as a very efficient partner for recombinant expression of small disulfide-rich proteins in E. coli H Nozach, C Fruchart-Gaillard, F Fenaille, F Beau, OHP Ramos, B Douzi, ... Microbial cell factories 12, 1-16, 2013 | 78 | 2013 |
Therapeutic inhibition of acid-sensing ion channel 1a recovers heart function after ischemia–reperfusion injury MA Redd, SE Scheuer, NJ Saez, Y Yoshikawa, HS Chiu, L Gao, M Hicks, ... Circulation 144 (12), 947-960, 2021 | 77 | 2021 |
Inhibition of acid‐sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain JYP Lee, NJ Saez, B Cristofori‐Armstrong, R Anangi, GF King, MT Smith, ... British Journal of Pharmacology 175 (12), 2204-2218, 2018 | 59 | 2018 |
High-throughput expression of animal venom toxins in Escherichia coli to generate a large library of oxidized disulphide-reticulated peptides for drug discovery J Turchetto, AF Sequeira, L Ramond, F Peysson, JLA Brás, NJ Saez, ... Microbial cell factories 16, 1-15, 2017 | 51 | 2017 |
High-Throughput Expression Screening and Purification of Recombinant Proteins in E. coli NJ Saez, R Vincentelli Structural genomics: general applications, 33-53, 2013 | 49 | 2013 |
Gene design, fusion technology and TEV cleavage conditions influence the purification of oxidized disulphide-rich venom peptides in Escherichia coli AF Sequeira, J Turchetto, NJ Saez, F Peysson, L Ramond, Y Duhoo, ... Microbial cell factories 16, 1-16, 2017 | 46 | 2017 |
Strategies for heterologous expression, synthesis, and purification of animal venom toxins E Rivera-de-Torre, C Rimbault, TP Jenkins, CV Sørensen, A Damsbo, ... Frontiers in bioengineering and biotechnology 9, 811905, 2022 | 41 | 2022 |
Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid‐sensing ion channel 1a NJ Saez, E Deplazes, B Cristofori‐Armstrong, IR Chassagnon, X Lin, ... British journal of pharmacology 172 (20), 4985-4995, 2015 | 41 | 2015 |
The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype-and species-dependent: Importance of interactions at the channel subunit interface and potential for … B Cristofori-Armstrong, NJ Saez, IR Chassagnon, GF King, LD Rash Biochemical Pharmacology 163, 381-390, 2019 | 33 | 2019 |
A Strategy for Production of Correctly Folded Disulfide-Rich Peptides in the Periplasm of E. coli NJ Saez, B Cristofori-Armstrong, R Anangi, GF King Heterologous Gene Expression in E. coli: Methods and Protocols, 155-180, 2017 | 33 | 2017 |
High throughput quantitative expression screening and purification applied to recombinant disulfide-rich venom proteins produced in E. coli NJ Saez, H Nozach, M Blemont, R Vincentelli Journal of visualized experiments: JoVE, 51464, 2014 | 23 | 2014 |
A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals DA Eagles, NJ Saez, B Krishnarjuna, JJ Bradford, YKY Chin, H Starobova, ... Proceedings of the National Academy of Sciences 119 (7), e2112630119, 2022 | 20 | 2022 |
A venomics approach coupled to high-throughput toxin production strategies identifies the first venom-derived melanocortin receptor agonists S Reynaud, J Ciolek, M Degueldre, NJ Saez, AF Sequeira, Y Duhoo, ... Journal of medicinal chemistry 63 (15), 8250-8264, 2020 | 20 | 2020 |
The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro SA Nixon, NJ Saez, V Herzig, GF King, AC Kotze Veterinary Parasitology 270, 40-46, 2019 | 16 | 2019 |