| Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity J Tsai, JT Lee, W Wang, J Zhang, H Cho, S Mamo, R Bremer, S Gillette, ... Proceedings of the National Academy of Sciences 105 (8), 3041-3046, 2008 | 1646 | 2008 |
| Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy F Chang, JT Lee, PM Navolanic, LS Steelman, JG Shelton, WL Blalock, ... Leukemia 17 (3), 590, 2003 | 1590 | 2003 |
| Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K J Villanueva, A Vultur, JT Lee, R Somasundaram, M Fukunaga-Kalabis, ... Cancer cell 18 (6), 683-695, 2010 | 1518 | 2010 |
| Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention F Chang, LS Steelman, JT Lee, JG Shelton, PM Navolanic, WL Blalock, ... Leukemia 17 (7), 1263, 2003 | 1077 | 2003 |
| Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance JA McCubrey, LS Steelman, SL Abrams, JT Lee, F Chang, FE Bertrand, ... Advances in enzyme regulation 46 (1), 249-279, 2006 | 873 | 2006 |
| Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway F Chang, LS Steelman, JG Shelton, JT Lee, PM Navolanic, WL Blalock, ... International journal of oncology 22 (3), 469-480, 2003 | 581 | 2003 |
| The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia JT Lee Jr, JA McCubrey Leukemia 16 (4), 486, 2002 | 374 | 2002 |
| Phosphatidylinositol 3′-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells JT Lee, LS Steelman, JA McCubrey Cancer Research 64 (22), 8397-8404, 2004 | 226 | 2004 |
| Human dermal stem cells differentiate into functional epidermal melanocytes L Li, M Fukunaga-Kalabis, H Yu, X Xu, J Kong, JT Lee, M Herlyn J Cell Sci 123 (6), 853-860, 2010 | 211 | 2010 |
| PLX4032, a potent inhibitor of the B‐Raf V600E oncogene, selectively inhibits V600E‐positive melanomas JT Lee, L Li, PA Brafford, M Van Den Eijnden, MB Halloran, K Sproesser, ... Pigment cell & melanoma research 23 (6), 820-827, 2010 | 202 | 2010 |
| Targeting prostate cancer based on signal transduction and cell cycle pathways JT Lee, BD Lehmann, DM Terrian, WH Chappell, F Stivala, M Libra, ... Cell cycle 7 (12), 1745-1762, 2008 | 140 | 2008 |
| Active Notch1 confers a transformed phenotype to primary human melanocytes CC Pinnix, JT Lee, ZJ Liu, R McDaid, K Balint, LJ Beverly, PA Brafford, ... Cancer research 69 (13), 5312-5320, 2009 | 136 | 2009 |
| Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells JG Shelton, LS Steelman, JT Lee, SL Knapp, WL Blalock, PW Moye, ... Oncogene 22 (16), 2478, 2003 | 125 | 2003 |
| Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors. JA McCubrey, M Milella, A Tafuri, AM Martelli, P Lunghi, A Bonati, ... Current opinion in investigational drugs (London, England: 2000) 9 (6), 614-630, 2008 | 122 | 2008 |
| Microenvironmental influences in melanoma progression JT Lee, M Herlyn Journal of cellular biochemistry 101 (4), 862-872, 2007 | 108 | 2007 |
| Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels KSM Smalley, R Contractor, NK Haass, JT Lee, KL Nathanson, ... British journal of cancer 96 (3), 445, 2007 | 107 | 2007 |
| Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells. JA McCubrey, JT Lee, LS Steelman, WL Blalock, PW Moye, F Chang, ... Cancer detection and prevention 25 (4), 375-393, 2001 | 89 | 2001 |
| The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes H Yu, R McDaid, J Lee, P Possik, L Li, SM Kumar, DE Elder, P Van Belle, ... The American journal of pathology 174 (6), 2367-2377, 2009 | 86 | 2009 |
| Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia WL Blalock, PM Navolanic, LS Steelman, JG Shelton, PW Moye, JT Lee, ... Leukemia 17 (6), 1058, 2003 | 83 | 2003 |
| Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas D Basu, KT Montone, LP Wang, PA Gimotty, R Hammond, JA Diehl, ... Cell cycle 10 (12), 2008-2016, 2011 | 73 | 2011 |