| Human vascular smooth muscle cells express receptors for CC chemokines IM Hayes, NJ Jordan, S Towers, G Smith, JR Paterson, JJ Earnshaw, ... Arteriosclerosis, thrombosis, and vascular biology 18 (3), 397-403, 1998 | 200 | 1998 |
| Designing drugs to avoid toxicity GF Smith Progress in medicinal chemistry 50, 1-47, 2011 | 145 | 2011 |
| Total synthesis of spinosyn A. 1. Enantioselective construction of a key tricyclic Intermediate by a multiple configurational inversion scheme LA Paquette, Z Gao, Z Ni, GF Smith Journal of the American Chemical Society 120 (11), 2543-2552, 1998 | 108 | 1998 |
| Discovery of selective RNA-binding small molecules by affinity-selection mass spectrometry NF Rizvi, JA Howe, A Nahvi, DJ Klein, TO Fischmann, HY Kim, MA McCoy, ... ACS chemical biology 13 (3), 820-831, 2018 | 103 | 2018 |
| Targeting Xist with compounds that disrupt RNA structure and X inactivation R Aguilar, KB Spencer, B Kesner, NF Rizvi, MD Badmalia, T Mrozowich, ... Nature 604 (7904), 160-166, 2022 | 91 | 2022 |
| The Landscape of Potential Small and Drug Substance Related Nitrosamines in Pharmaceuticals J Schlingemann, MJ Burns, DJ Ponting, CM Avila, NE Romero, ... Journal of Pharmaceutical Sciences, 2022 | 81 | 2022 |
| Targeting RNA with small molecules: identification of selective, RNA-binding small molecules occupying drug-like chemical space NF Rizvi, JP Santa Maria Jr, A Nahvi, J Klappenbach, DJ Klein, PJ Curran, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (4), 384-396, 2020 | 80 | 2020 |
| RNA as a small molecule druggable target NF Rizvi, GF Smith Bioorganic & Medicinal Chemistry Letters 27 (23), 5083-5088, 2017 | 74 | 2017 |
| Medicinal chemistry by the numbers: the physicochemistry, thermodynamics and kinetics of modern drug design GF Smith Progress in medicinal chemistry 48, 1-29, 2009 | 47 | 2009 |
| Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4 J Lim, MD Altman, J Baker, JD Brubaker, H Chen, Y Chen, T Fischmann, ... ACS medicinal chemistry letters 6 (6), 683-688, 2015 | 46 | 2015 |
| Prediction of in vivo pharmacokinetic parameters and time–exposure curves in rats using machine learning from the chemical structure O Obrezanova, A Martinsson, T Whitehead, S Mahmoud, A Bender, ... Molecular pharmaceutics 19 (5), 1488-1504, 2022 | 41 | 2022 |
| Synthetic studies on spinosyn A. Convenient enantioselective construction of a suitably functionalized trans, anti, cis-decahydro-as-indacene intermediate via [3.3] sigmatropy … LA Paquette, Z Gao, Z Ni, GF Smith Tetrahedron letters 38 (8), 1271-1274, 1997 | 41 | 1997 |
| (4R)-(+)-TERT-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE:(2-CYCLOPENTEN-1-ONE, 4-1, 1-DIMETHYLETHYL) DIMETHYLSILYLOXY-,(R)- LA Paquette, MJ Earle, GF Smith Organic syntheses 73, 36-43, 1996 | 36 | 1996 |
| The nitrosamine “saga”: lessons learned from five years of scrutiny R Nudelman, G Kocks, B Mouton, DJ Ponting, J Schlingemann, S Simon, ... Organic Process Research & Development 27 (10), 1719-1735, 2023 | 35 | 2023 |
| Identification of N-(1H-pyrazol-4-yl) carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications J Lim, MD Altman, J Baker, JD Brubaker, H Chen, Y Chen, MA Kleinschek, ... Bioorganic & Medicinal Chemistry Letters 25 (22), 5384-5388, 2015 | 32 | 2015 |
| Inhibitors of IRAK4 activity MD Altman, JD Brubaker, ML Childers, A Donofrio, T Fischmann, ... US Patent 9,926,330, 2018 | 31 | 2018 |
| Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation GF Smith, MD Altman, B Andresen, J Baker, JD Brubaker, H Chen, ... Bioorganic & medicinal chemistry letters 27 (12), 2721-2726, 2017 | 29 | 2017 |
| The application of non-combinatorial chemistry to lead discovery J Everett, M Gardner, F Pullen, GF Smith, M Snarey, N Terrett Drug discovery today 6 (15), 779-785, 2001 | 29 | 2001 |
| Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy W McCoull, S Boyd, MR Brown, M Coen, O Collingwood, NL Davies, ... Journal of Medicinal Chemistry 64 (18), 13524-13539, 2021 | 23 | 2021 |
| Structure–activity relationships of novel non-competitive mGluR1 antagonists: A potential treatment for chronic pain DR Owen, PG Dodd, S Gayton, BS Greener, GW Harbottle, SJ Mantell, ... Bioorganic & medicinal chemistry letters 17 (2), 486-490, 2007 | 23 | 2007 |
Noreen F. RizviMerck Research Labsยืนยันอีเมลแล้วที่ merck.com
