Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation D Klysz, X Tai, PA Robert, M Craveiro, G Cretenet, L Oburoglu, ... Science signaling 8 (396), ra97-ra97, 2015 | 508 | 2015 |
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling EW Weber, KR Parker, E Sotillo, RC Lynn, H Anbunathan, J Lattin, ... Science 372 (6537), eaba1786, 2021 | 485 | 2021 |
Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification L Oburoglu, S Tardito, V Fritz, SC De Barros, P Merida, M Craveiro, ... Cell stem cell 15 (2), 169-184, 2014 | 310 | 2014 |
Enhanced safety and efficacy of protease-regulated CAR-T cell receptors L Labanieh, RG Majzner, D Klysz, E Sotillo, CJ Fisher, JG Vilches-Moure, ... Cell 185 (10), 1745-1763. e22, 2022 | 158 | 2022 |
Co-opting signalling molecules enables logic-gated control of CAR T cells AM Tousley, MC Rotiroti, L Labanieh, LW Rysavy, WJ Kim, C Lareau, ... Nature 615 (7952), 507-516, 2023 | 155 | 2023 |
Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors AK Grosskopf, L Labanieh, DD Klysz, GA Roth, P Xu, O Adebowale, ... Science advances 8 (14), eabn8264, 2022 | 139 | 2022 |
GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity S Heitzeneder, KR Bosse, Z Zhu, D Zhelev, RG Majzner, MT Radosevich, ... Cancer Cell 40 (1), 53-69. e9, 2022 | 129 | 2022 |
Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery SH Chiou, D Tseng, A Reuben, V Mallajosyula, IS Molina, S Conley, ... Immunity 54 (3), 586-602. e8, 2021 | 110 | 2021 |
Enhanced T cell effector activity by targeting the Mediator kinase module KA Freitas, JA Belk, E Sotillo, PJ Quinn, MC Ramello, M Malipatlolla, ... Science 378 (6620), eabn5647, 2022 | 77 | 2022 |
FOXO1 is a master regulator of memory programming in CAR T cells AE Doan, KP Mueller, AY Chen, GT Rouin, Y Chen, B Daniel, J Lattin, ... Nature 629 (8010), 211-218, 2024 | 57 | 2024 |
Inosine induces stemness features in CAR-T cells and enhances potency DD Klysz, C Fowler, M Malipatlolla, L Stuani, KA Freitas, Y Chen, S Meier, ... Cancer Cell 42 (2), 266-282. e8, 2024 | 44 | 2024 |
PET reporter gene imaging and ganciclovir-mediated ablation of chimeric antigen receptor T cells in solid tumors S Murty, L Labanieh, T Murty, G Gowrishankar, T Haywood, IS Alam, ... Cancer Research 80 (21), 4731-4740, 2020 | 42 | 2020 |
A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells V Tieu, E Sotillo, JR Bjelajac, C Chen, M Malipatlolla, JA Guerrero, P Xu, ... Cell 187 (5), 1278-1295. e20, 2024 | 39 | 2024 |
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling. Science 372, eaba1786 EW Weber, KR Parker, E Sotillo, RC Lynn, H Anbunathan, J Lattin, ... | 39 | 2021 |
Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas M Monje, J Mahdi, R Majzner, KW Yeom, LM Schultz, RM Richards, ... Nature, 1-8, 2024 | 10 | 2024 |
CD22-directed CAR T-cell therapy for large B-cell lymphomas progressing after CD19-directed CAR T-cell therapy: a dose-finding phase 1 study MJ Frank, JH Baird, AM Kramer, HK Srinagesh, S Patel, AK Brown, ... The Lancet 404 (10450), 353-363, 2024 | 10 | 2024 |
GLUT1 overexpression in CAR-T cells induces metabolic reprogramming and enhances potency JA Guerrero, DD Klysz, Y Chen, M Malipatlolla, J Lone, C Fowler, L Stuani, ... Nature Communications 15 (1), 8658, 2024 | 6 | 2024 |
FOXO1 is a master regulator of CAR T memory programming A Doan, KP Mueller, A Chen, GT Rouin, B Daniel, J Lattin, Y Chen, ... Research Square, rs. 3. rs-2802998, 2023 | 5 | 2023 |
Sequential intravenous and intracerebroventricular GD2-CAR T-cell therapy for H3K27M-mutated diffuse midline gliomas M Monje, J Mahdi, R Majzner, K Yeom, LM Schultz, RM Richards, ... medRxiv, 2024.06. 25.24309146, 2024 | 3 | 2024 |
FOXO1 is a master regulator of CAR T memory programming C Mackall, A Doan, K Mueller, A Chen, G Rouin, B Daniel, J Lattin, ... | 2 | 2023 |