| Generation of functional human 3D cortico-motor assembloids J Andersen, O Revah, Y Miura, N Thom, ND Amin, KW Kelley, M Singh, ... Cell 183 (7), 1913-1929. e26, 2020 | 454 | 2020 |
| Maturation and circuit integration of transplanted human cortical organoids O Revah, F Gore, KW Kelley, J Andersen, N Sakai, X Chen, MY Li, F Birey, ... Nature 610 (7931), 319-326, 2022 | 319 | 2022 |
| Adenoviral vector delivery of RNA-guided CRISPR/Cas9 nuclease complexes induces targeted mutagenesis in a diverse array of human cells I Maggio, M Holkers, J Liu, JM Janssen, X Chen, MAFV Gonçalves Scientific reports 4 (1), 5105, 2014 | 172 | 2014 |
| Engineered viruses as genome editing devices X Chen, MAFV Gonçalves Molecular Therapy 24 (3), 447-457, 2016 | 171 | 2016 |
| Probing the impact of chromatin conformation on genome editing tools X Chen, M Rinsma, JM Janssen, J Liu, I Maggio, MAFV Gonçalves Nucleic acids research 44 (13), 6482-6492, 2016 | 160 | 2016 |
| In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting X Chen, JM Janssen, J Liu, I Maggio, AEJ ‘t Jong, HMM Mikkers, ... Nature Communications 8 (1), 657, 2017 | 94 | 2017 |
| Selection-free gene repair after adenoviral vector transduction of designer nucleases: rescue of dystrophin synthesis in DMD muscle cell populations I Maggio, L Stefanucci, JM Janssen, J Liu, X Chen, V Mouly, ... Nucleic acids research 44 (3), 1449-1470, 2016 | 93 | 2016 |
| Adenoviral vectors encoding CRISPR/Cas9 multiplexes rescue dystrophin synthesis in unselected populations of DMD muscle cells I Maggio, J Liu, JM Janssen, X Chen, MAFV Gonçalves Scientific reports 6 (1), 37051, 2016 | 84 | 2016 |
| The chromatin structure of CRISPR-Cas9 target DNA controls the balance between mutagenic and homology-directed gene-editing events JM Janssen, X Chen, J Liu, MAFV Gonçalves Molecular Therapy-Nucleic Acids 16, 141-154, 2019 | 64 | 2019 |
| Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment X Meng, D Yao, K Imaizumi, X Chen, KW Kelley, N Reis, MV Thete, ... Nature 622 (7982), 359-366, 2023 | 61 | 2023 |
| The modest impact of transcription factor Nrf2 on the course of disease in an ALS animal model Y Guo, Y Zhang, D Wen, W Duan, T An, P Shi, J Wang, Z Li, X Chen, C Li Laboratory Investigation 93 (7), 825-833, 2013 | 53 | 2013 |
| The chromatin structure differentially impacts high-specificity CRISPR-Cas9 nuclease strategies X Chen, J Liu, JM Janssen, MAFV Gonçalves Molecular Therapy Nucleic Acids 8, 558-563, 2017 | 51 | 2017 |
| DNA, RNA, and protein tools for editing the genetic information in human cells X Chen, MAFV Gonçalves Iscience 6, 247-263, 2018 | 50 | 2018 |
| Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids X Yang, C Forró, TL Li, Y Miura, TJ Zaluska, CT Tsai, S Kanton, ... Nature Biotechnology, 1-8, 2024 | 44 | 2024 |
| Antisense oligonucleotide therapeutic approach for Timothy syndrome X Chen, F Birey, MY Li, O Revah, R Levy, MV Thete, N Reis, ... Nature 628 (8009), 818-825, 2024 | 34 | 2024 |
| Expanding the editable genome and CRISPR–Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking X Chen, F Tasca, Q Wang, J Liu, JM Janssen, MD Brescia, M Bellin, ... Nucleic Acids Research 48 (2), 974-995, 2020 | 33 | 2020 |
| The emerging role of viral vectors as vehicles for DMD gene editing I Maggio, X Chen, MAFV Gonçalves Genome medicine 8, 1-10, 2016 | 31 | 2016 |
| Single-cell transcriptomic landscape of the developing human spinal cord J Andersen, N Thom, JL Shadrach, X Chen, MM Onesto, ND Amin, ... Nature Neuroscience 26 (5), 902-914, 2023 | 30 | 2023 |
| Neuroprotection by monocarbonyl dimethoxycurcumin C: ameliorating the toxicity of mutant TDP-43 via HO-1 W Duan, Y Guo, J Xiao, X Chen, Z Li, H Han, C Li Molecular neurobiology 49, 368-379, 2014 | 26 | 2014 |
| Assembloid model to study loop circuits of the human nervous system Y Miura, J Kim, O Jurjuț, KW Kelley, X Yang, X Chen, MV Thete, O Revah, ... bioRxiv, 2024 | 5 | 2024 |