Cysteine proteases of parasitic organisms M Sajid, JH McKerrow Molecular and biochemical parasitology 120 (1), 1-21, 2002 | 1146 | 2002 |
Protease inhibitors targeting coronavirus and filovirus entry Y Zhou, P Vedantham, K Lu, J Agudelo, R Carrion Jr, JW Nunneley, ... Antiviral research 116, 76-84, 2015 | 659 | 2015 |
Tumour necrosis factor α restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice P Amiri, RM Locksley, TG Parslow, M Sadickt, E Rector, D Ritter, ... Nature 356 (6370), 604-607, 1992 | 586 | 1992 |
In vitro antimalarial activity of chalcones and their derivatives R Li, GL Kenyon, FE Cohen, X Chen, B Gong, JN Dominguez, E Davidson, ... Journal of medicinal chemistry 38 (26), 5031-5037, 1995 | 570 | 1995 |
The proteases and pathogenicity of parasitic protozoa JH McKerrow, E Sun, PJ Rosenthal, J Bouvier Annual review of microbiology 47, 821-854, 1993 | 554 | 1993 |
Synthesis and structure− activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain X Du, C Guo, E Hansell, PS Doyle, CR Caffrey, TP Holler, JH McKerrow, ... Journal of medicinal chemistry 45 (13), 2695-2707, 2002 | 552 | 2002 |
Proteases in parasitic diseases JH McKerrow, C Caffrey, B Kelly, P Loke, M Sajid Annu. Rev. Pathol. Mech. Dis. 1 (1), 497-536, 2006 | 527 | 2006 |
Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection JC Engel, PS Doyle, I Hsieh, JH McKerrow Journal of Experimental Medicine 188 (4), 725-734, 1998 | 527 | 1998 |
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-β independent M Kaviratne, M Hesse, M Leusink, AW Cheever, SJ Davies, JH McKerrow, ... The Journal of Immunology 173 (6), 4020-4029, 2004 | 506 | 2004 |
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum. PJ Rosenthal, JH McKerrow, M Aikawa, H Nagasawa, JH Leech The Journal of clinical investigation 82 (5), 1560-1566, 1988 | 451 | 1988 |
Drug discovery and development for neglected parasitic diseases AR Renslo, JH McKerrow Nature chemical biology 2 (12), 701-710, 2006 | 426 | 2006 |
Anisakiasis JA Sakanari, JH Mckerrow Clinical microbiology reviews 2 (3), 278-284, 1989 | 393 | 1989 |
Structure-based inhibitor design by using protein models for the development of antiparasitic agents. CS Ring, E Sun, JH McKerrow, GK Lee, PJ Rosenthal, ID Kuntz, ... Proceedings of the national academy of Sciences 90 (8), 3583-3587, 1993 | 391 | 1993 |
The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi. AE Eakin, AA Mills, G Harth, JH McKerrow, CS Craik Journal of Biological Chemistry 267 (11), 7411-7420, 1992 | 377 | 1992 |
Synthesis and Structure−Activity Relationships of Parasiticidal Thiosemicarbazone Cysteine Protease Inhibitors against Plasmodium falciparum, Trypanosoma brucei, and … DC Greenbaum, Z Mackey, E Hansell, P Doyle, J Gut, CR Caffrey, ... Journal of medicinal chemistry 47 (12), 3212-3219, 2004 | 365 | 2004 |
Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor MH Abdulla, KC Lim, M Sajid, JH McKerrow, CR Caffrey PLoS medicine 4 (1), e14, 2007 | 350 | 2007 |
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target A Debnath, D Parsonage, RM Andrade, C He, ER Cobo, K Hirata, S Chen, ... Nature medicine 18 (6), 956-960, 2012 | 349 | 2012 |
Parasite proteases. JH McKerrow | 343 | 1989 |
Controlled deamidation of peptides and proteins: an experimental hazard and a possible biological timer AB Robinson, JH McKerrow, P Cary Proceedings of the National Academy of Sciences 66 (3), 753-757, 1970 | 341 | 1970 |
The crystal structure of cruzain: a therapeutic target for Chagas' disease ME McGrath, AE Eakin, JC Engel, JH McKerrow, CS Craik, RJ Fletterick Journal of molecular biology 247 (2), 251-259, 1995 | 334 | 1995 |