| LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented … AA Koshkin, SK Singh, P Nielsen, VK Rajwanshi, R Kumar, M Meldgaard, ... tetrahedron 54 (14), 3607-3630, 1998 | 1472 | 1998 |
| LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition SK Singh, AA Koshkin, J Wengel, P Nielsen Chemical communications, 455-456, 1998 | 839 | 1998 |
| Oligonucleotide analogues J Wengel, P Nielsen US Patent 6,794,499, 2004 | 750 | 2004 |
| Oligonucleotide analogues J Wengel, P Nielsen US Patent 6,670,461, 2003 | 742 | 2003 |
| Oligonucleotide analogues J Wengel, P Nielsen US Patent 7,034,133, 2006 | 579 | 2006 |
| LNA (locked nucleic acid): an RNA mimic forming exceedingly stable LNA: LNA duplexes AA Koshkin, P Nielsen, M Meldgaard, VK Rajwanshi, SK Singh, J Wengel Journal of the American Chemical Society 120 (50), 13252-13253, 1998 | 452 | 1998 |
| A Novel Class of Oligonucleotide Analogues Containing 2‘-O,3‘-C-Linked [3.2.0]Bicycloarabinonucleoside Monomers: Synthesis, Thermal Affinity Studies, and … NK Christensen, M Petersen, P Nielsen, JP Jacobsen, CE Olsen, ... Journal of the American Chemical Society 120 (22), 5458-5463, 1998 | 199 | 1998 |
| Palladium‐Catalyzed Three‐Component Approach to Promazine with Formation of One Carbon–Sulfur and Two Carbon–Nitrogen Bonds T Dahl, CW Tornøe, B Bang‐Andersen, P Nielsen, M Jørgensen Angewandte Chemie International Edition 47 (9), 1726-1728, 2008 | 148 | 2008 |
| The eight stereoisomers of LNA (locked nucleic acid): a remarkable family of strong RNA binding molecules VK Rajwanshi, AE Håkansson, MD Sørensen, S Pitsch, SK Singh, ... Angewandte Chemie 112 (9), 1722-1725, 2000 | 130 | 2000 |
| Oligonucleotide analogues J Wengel, P Nielsen US Patent 8,153,365, 2012 | 128 | 2012 |
| Synthesis and evaluation of oligodeoxynucleotides containing acyclic nucleosides: introduction of three novel analogues and a summary P Nielsen, LH Dreiøe, J Wengel Bioorganic & medicinal chemistry 3 (1), 19-28, 1995 | 127 | 1995 |
| Oligonucleotide analogues J Wengel, P Nielsen US Patent 8,080,644, 2011 | 123 | 2011 |
| Synthesis of 5‐(1, 2, 3‐Triazol‐4‐yl)‐2′‐deoxyuridines by a Click Chemistry Approach: Stacking of Triazoles in the Major Groove Gives Increased Nucleic Acid Duplex Stability P Kočalka, NK Andersen, F Jensen, P Nielsen ChemBioChem 8 (17), 2106-2116, 2007 | 107 | 2007 |
| LNA (locked nucleic acid) J Wengel, A Koshkin, SK Singh, P Nielsen, M Meldgaard, VK Rajwanshi, ... Nucleosides & Nucleotides 18 (6-7), 1365-1370, 1999 | 105 | 1999 |
| Analogues of a Locked Nucleic Acid with Three-Carbon 2 ‘, 4 ‘-Linkages: Synthesis by Ring-Closing Metathesis and Influence on Nucleic Acid Duplex Stability and Structure N Albaek, M Petersen, P Nielsen The Journal of Organic Chemistry 71 (20), 7731-7740, 2006 | 94 | 2006 |
| Synthesis of 2′-O, 3′-C-linked bicyclic nucleosides and bicyclic oligonucleotides P Nielsen, HM Pfundheller, CE Olsen, J Wengel Journal of the Chemical Society, Perkin Transactions 1, 3423-3434, 1997 | 92 | 1997 |
| A click chemistry approach to pleuromutilin conjugates with nucleosides or acyclic nucleoside derivatives and their binding to the bacterial ribosome L Lolk, J Pøhlsgaard, AS Jepsen, LH Hansen, H Nielsen, SI Steffansen, ... Journal of medicinal chemistry 51 (16), 4957-4967, 2008 | 91 | 2008 |
| A novel class of conformationally restricted oligonucleotide analogues: synthesis of 2′, 3′-bridged monomers and RNA-selective hybridisation P Nielsen, HM Pfundheller, J Wengel Chemical Communications, 825-826, 1997 | 90 | 1997 |
| Bone remodelling around HA-coated acetabular cups: a DEXA study with a 3-year follow-up in a randomised trial MB Laursen, PT Nielsen, K Søballe International orthopaedics 31, 199-204, 2007 | 77 | 2007 |
| Synthesis of conformationally restricted dinucleotides by ring-closing metathesis AM Sørensen, P Nielsen Organic Letters 2 (26), 4217-4219, 2000 | 64 | 2000 |
