| Adipose tissue as an endocrine organ EE Kershaw, JS Flier The Journal of Clinical Endocrinology & Metabolism 89 (6), 2548-2556, 2004 | 7610 | 2004 |
| Obesity and insulin resistance BB Kahn, JS Flier The Journal of clinical investigation 106 (4), 473-481, 2000 | 4728 | 2000 |
| TLR4 links innate immunity and fatty acid–induced insulin resistance H Shi, MV Kokoeva, K Inouye, I Tzameli, H Yin, JS Flier The Journal of clinical investigation 116 (11), 3015-3025, 2006 | 4469 | 2006 |
| Role of leptin in the neuroendocrine response to fasting RS Ahima, D Prabakaran, C Mantzoros, D Qu, B Lowell, E Maratos-Flier, ... Nature 382 (6588), 250-252, 1996 | 4166 | 1996 |
| Obesity and the regulation of energy balance BM Spiegelman, JS Flier cell 104 (4), 531-543, 2001 | 3296 | 2001 |
| Leptin RS Ahima, JS Flier Annual review of physiology 62 (1), 413-437, 2000 | 2747 | 2000 |
| Adipose tissue as an endocrine organ RS Ahima, JS Flier Trends in Endocrinology & Metabolism 11 (8), 327-332, 2000 | 2344 | 2000 |
| A transgenic model of visceral obesity and the metabolic syndrome H Masuzaki, J Paterson, H Shinyama, NM Morton, JJ Mullins, JR Seckl, ... Science 294 (5549), 2166-2170, 2001 | 2342 | 2001 |
| Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action RC Frederich, A Hamann, S Anderson, B Löllmann, BB Lowell, JS Flier Nature medicine 1 (12), 1311-1314, 1995 | 2171 | 1995 |
| Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states MK Badman, P Pissios, AR Kennedy, G Koukos, JS Flier, E Maratos-Flier Cell metabolism 5 (6), 426-437, 2007 | 1804 | 2007 |
| Adipogenesis and obesity: rounding out the big picture BM Spiegelman, JS Flier Cell 87 (3), 377-389, 1996 | 1694 | 1996 |
| Obesity wars: molecular progress confronts an expanding epidemic JS Flier Cell 116 (2), 337-350, 2004 | 1680 | 2004 |
| FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis S Kleiner, N Douris, EC Fox, RJ Mepani, F Verdeguer, J Wu, ... Genes & development 26 (3), 271-281, 2012 | 1663 | 2012 |
| The organization, promoter analysis, and expression of the human PPARγ gene L Fajas, D Auboeuf, E Raspé, K Schoonjans, AM Lefebvre, R Saladin, ... Journal of Biological Chemistry 272 (30), 18779-18789, 1997 | 1657 | 1997 |
| The syndromes of insulin resistance and acanthosis nigricans: insulin-receptor disorders in man CR Kahn, JS Flier, RS Bar, JA Archer, P Gorden, MM Martin, J Roth New England Journal of Medicine 294 (14), 739-745, 1976 | 1491 | 1976 |
| Mice lacking melanin-concentrating hormone are hypophagic and lean M Shimada, NA Tritos, BB Lowell, JS Flier, E Maratos-Flier Nature 396 (6712), 670-674, 1998 | 1412 | 1998 |
| Distributions of leptin receptor mRNA isoforms in the rat brain JK Elmquist, C Bjørbæk, RS Ahima, JS Flier, CB Saper Journal of Comparative Neurology 395 (4), 535-547, 1998 | 1351 | 1998 |
| Identification of SOCS-3 as a potential mediator of central leptin resistance C Bjørbæk, JK Elmquist, JD Frantz, SE Shoelson, JS Flier Molecular cell 1 (4), 619-625, 1998 | 1296 | 1998 |
| Insulin resistance—mechanisms, syndromes, and implications DE Moller, JS Flier New England Journal of Medicine 325 (13), 938-948, 1991 | 1273 | 1991 |
| Development of obesity in transgenic mice after genetic ablation of brown adipose tissue BB Lowell, V S-Susulic, A Hamann, JA Lawitts, J Himms-Hagen, BB Boyer, ... Nature 366 (6457), 740-742, 1993 | 1249 | 1993 |