| Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel RC Moore, IY Lee, GL Silverman, PM Harrison, R Strome, C Heinrich, ... Journal of molecular biology 292 (4), 797-817, 1999 | 701 | 1999 |
| Presenilin-1, Nicastrin, Amyloid Precursor Protein, and g-Secretase Activity Are Co-localized in the Lysosomal Membrane. SH Pasternak, RD Bagshaw, M Guiral, S Zhang, CA Ackerley, BJ Pak, ... Journal of Biological Chemistry 278 (29), 26687-26694, 2003 | 401 | 2003 |
| The effects of oxytocin on social cognition and behaviour in frontotemporal dementia S Jesso, D Morlog, S Ross, MD Pell, SH Pasternak, DGV Mitchell, ... Brain 134 (9), 2493-2501, 2011 | 170 | 2011 |
| The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective SH Pasternak, JW Callahan, DJ Mahuran Journal of Alzheimer's Disease 6 (1), 53-65, 2004 | 155 | 2004 |
| Ambroxol as a novel disease-modifying treatment for Parkinson’s disease dementia: Protocol for a single-centre, randomized, double-blind, placebo-controlled trial CRA Silveira, J MacKinley, K Coleman, Z Li, E Finger, R Bartha, ... BMC neurology 19, 1-10, 2019 | 131 | 2019 |
| Four‐pool modeling of proton exchange processes in biological systems in the presence of MRI–paramagnetic chemical exchange saturation transfer (PARACEST) agents AX Li, RHE Hudson, JW Barrett, CK Jones, SH Pasternak, R Bartha Magnetic Resonance in Medicine: An Official Journal of the International …, 2008 | 127 | 2008 |
| Oxytocin for frontotemporal dementia: a randomized dose-finding study of safety and tolerability EC Finger, J MacKinley, M Blair, LD Oliver, S Jesso, MC Tartaglia, ... Neurology 84 (2), 174-181, 2015 | 110 | 2015 |
| Amyloid and Alzheimer's disease: inside and out JHK Tam, SH Pasternak Canadian Journal of Neurological Sciences 39 (3), 286-298, 2012 | 98 | 2012 |
| The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid JHK Tam, C Seah, SH Pasternak Molecular brain 7, 1-18, 2014 | 93 | 2014 |
| Characterizing heterogeneity in neuroimaging, cognition, clinical symptoms, and genetics among patients with late-life depression J Wen, CHY Fu, D Tosun, Y Veturi, Z Yang, A Abdulkadir, E Mamourian, ... JAMA psychiatry 79 (5), 464-474, 2022 | 88 | 2022 |
| Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway A Lorenzen, J Samosh, K Vandewark, PH Anborgh, C Seah, ... Molecular brain 3, 1-13, 2010 | 84 | 2010 |
| S-Nitrosylation in Alzheimer's disease QF Zhao, JT Yu, L Tan Molecular neurobiology 51 (1), 268-280, 2015 | 72 | 2015 |
| Depressive symptoms negatively impact Montreal Cognitive Assessment performance: a memory clinic experience M Blair, K Coleman, S Jesso, VD Jodoin, K Smolewska, E Warriner, ... Canadian Journal of Neurological Sciences 43 (4), 513-517, 2016 | 62 | 2016 |
| Oligomeric aggregates of amyloid β peptide 1–42 activate ERK/MAPK in SH-SY5Y cells via the α7 nicotinic receptor KF Young, SH Pasternak, RJ Rylett Neurochemistry international 55 (8), 796-801, 2009 | 61 | 2009 |
| Nicastrin is a resident lysosomal membrane protein RD Bagshaw, SH Pasternak, DJ Mahuran, JW Callahan Biochemical and biophysical research communications 300 (3), 615-618, 2003 | 54 | 2003 |
| Vitamin E in aging persons with Down syndrome: A randomized, placebo-controlled clinical trial M Sano, PS Aisen, HF Andrews, WY Tsai, F Lai, AJ Dalton, ... Neurology 86 (22), 2071-2076, 2016 | 52 | 2016 |
| MIiSR: molecular interactions in super-resolution imaging enables the analysis of protein interactions, dynamics and formation of multi-protein structures FA Caetano, BS Dirk, JHK Tam, PC Cavanagh, M Goiko, SSG Ferguson, ... PLoS computational biology 11 (12), e1004634, 2015 | 48 | 2015 |
| Reduced hippocampal glutamate and posterior cingulate N-acetyl aspartate in mild cognitive impairment and Alzheimer’s disease is associated with episodic memory performance and … D Wong, S Atiya, J Fogarty, M Montero-Odasso, SH Pasternak, C Brymer, ... Journal of Alzheimer’s disease 73 (4), 1385-1405, 2020 | 46 | 2020 |
| Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes W Tang, JHK Tam, C Seah, J Chiu, A Tyrer, SP Cregan, SO Meakin, ... Molecular brain 8, 1-21, 2015 | 44 | 2015 |
| A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies M Suchý, R Ta, AX Li, F Wojciechowski, SH Pasternak, R Bartha, ... Organic & Biomolecular Chemistry 8 (11), 2560-2566, 2010 | 44 | 2010 |
