| Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened JK Chen, J Taipale, MK Cooper, PA Beachy Genes & development 16 (21), 2743-2748, 2002 | 1845 | 2002 |
| Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine J Taipale, JK Chen, MK Cooper, B Wang, RK Mann, L Milenkovic, ... Nature 406 (6799), 1005-1009, 2000 | 1617 | 2000 |
| Structural basis for the binding of proline-rich peptides to SH3 domains H Yu, JK Chen, S Feng, DC Dalgarno, AW Brauer, SL Schrelber Cell 76 (5), 933-945, 1994 | 1345 | 1994 |
| Small molecule modulation of Smoothened activity JK Chen, J Taipale, KE Young, T Maiti, PA Beachy Proceedings of the National Academy of Sciences 99 (22), 14071-14076, 2002 | 1166 | 2002 |
| Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions S Feng, JK Chen, H Yu, JA Simon, SL Schreiber Science 266 (5188), 1241-1247, 1994 | 1097 | 1994 |
| Medulloblastoma growth inhibition by hedgehog pathway blockade DM Berman, SS Karhadkar, AR Hallahan, JI Pritchard, CG Eberhart, ... Science 297 (5586), 1559-1561, 2002 | 1044 | 2002 |
| Stromal response to Hedgehog signaling restrains pancreatic cancer progression JJ Lee, RM Perera, H Wang, DC Wu, XS Liu, S Han, J Fitamant, PD Jones, ... Proceedings of the National Academy of Sciences 111 (30), E3091-E3100, 2014 | 553 | 2014 |
| Organic wastewater treatment by a single-atom catalyst and electrolytically produced H 2 O 2 J Xu, X Zheng, Z Feng, Z Lu, Z Zhang, W Huang, Y Li, D Vuckovic, Y Li, ... Nature Sustainability 4 (3), 233-241, 2021 | 522 | 2021 |
| Purmorphamine activates the Hedgehog pathway by targeting Smoothened S Sinha, JK Chen Nature chemical biology 2 (1), 29-30, 2006 | 466 | 2006 |
| Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein AJ Firestone, JS Weinger, M Maldonado, K Barlan, LD Langston, ... Nature 484 (7392), 125-129, 2012 | 420 | 2012 |
| The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome AJ Kuo, J Song, P Cheung, S Ishibe-Murakami, S Yamazoe, JK Chen, ... Nature 484 (7392), 115-119, 2012 | 402 | 2012 |
| A small molecule that binds Hedgehog and blocks its signaling in human cells BZ Stanton, LF Peng, N Maloof, K Nakai, X Wang, JL Duffner, KM Taveras, ... Nature chemical biology 5 (3), 154-156, 2009 | 379 | 2009 |
| Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade JM Hyman, AJ Firestone, VM Heine, Y Zhao, CA Ocasio, K Han, M Sun, ... Proceedings of the National Academy of Sciences 106 (33), 14132-14137, 2009 | 365 | 2009 |
| Activity-dependent internalization of smoothened mediated by ß-arrestin 2 and GRK2 W Chen, XR Ren, CD Nelson, LS Barak, JK Chen, PA Beachy, ... Science 306 (5705), 2257-2260, 2004 | 357 | 2004 |
| A crucial requirement for Hedgehog signaling in small cell lung cancer KS Park, LG Martelotto, M Peifer, ML Sos, AN Karnezis, MR Mahjoub, ... Nature medicine 17 (11), 1504-1508, 2011 | 294 | 2011 |
| Light-controlled gene silencing in zebrafish embryos IA Shestopalov, S Sinha, JK Chen Nature chemical biology 3 (10), 650-651, 2007 | 255 | 2007 |
| An inducible long noncoding RNA amplifies DNA damage signaling AM Schmitt, JT Garcia, T Hung, RA Flynn, Y Shen, K Qu, AY Payumo, ... Nature genetics 48 (11), 1370-1376, 2016 | 254 | 2016 |
| Biased combinatorial libraries: novel ligands for the SH3 domain of phosphatidylinositol 3-kinase JK Chen, WS Lane, AW Brauer, A Tanaka, SL Schreiber Journal of the American Chemical Society 115 (26), 12591-12592, 1993 | 190 | 1993 |
| A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies DK Breslow, S Hoogendoorn, AR Kopp, DW Morgens, BK Vu, ... Nature genetics 50 (3), 460-471, 2018 | 182 | 2018 |
| General method for regulating protein stability with light KM Bonger, R Rakhit, AY Payumo, JK Chen, TJ Wandless ACS chemical biology 9 (1), 111-115, 2014 | 169 | 2014 |
