| Dual role of phosphatidylinositol-3, 4, 5-trisphosphate in the activation of protein kinase B D Stokoe, LR Stephens, T Copeland, PRJ Gaffney, CB Reese, GF Painter, ... Science 277 (5325), 567-570, 1997 | 1658 | 1997 |
| Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine EH Walker, ME Pacold, O Perisic, L Stephens, PT Hawkins, MP Wymann, ... Molecular cell 6 (4), 909-919, 2000 | 1552 | 2000 |
| Protein kinase B kinases that mediate phosphatidylinositol 3, 4, 5-trisphosphate-dependent activation of protein kinase B L Stephens, K Anderson, D Stokoe, H Erdjument-Bromage, GF Painter, ... Science 279 (5351), 710-714, 1998 | 1431 | 1998 |
| PI3K signalling: the path to discovery and understanding B Vanhaesebroeck, L Stephens, P Hawkins Nature reviews Molecular cell biology 13 (3), 195-203, 2012 | 1138 | 2012 |
| Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ ME Pacold, S Suire, O Perisic, S Lara-Gonzalez, CT Davis, EH Walker, ... Cell 103 (6), 931-944, 2000 | 801 | 2000 |
| A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits L Stephens, A Smrcka, FT Cooke, TR Jackson, PC Sternweis, PT Hawkins Cell 77 (1), 83-93, 1994 | 796 | 1994 |
| Signalling through Class I PI3Ks in mammalian cells PT Hawkins, KE Anderson, K Davidson, LR Stephens Biochemical Society Transactions 34 (5), 647-662, 2006 | 738 | 2006 |
| The Gβγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101 LR Stephens, A Eguinoa, H Erdjument-Bromage, M Lui, F Cooke, ... Cell 89 (1), 105-114, 1997 | 732 | 1997 |
| PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase PT Hawkins, A Eguinoa, RG Qiu, D Stokoe, FT Cooke, R Walters, ... Current Biology 5 (4), 393-403, 1995 | 704 | 1995 |
| Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage I Angulo, O Vadas, F Garçon, E Banham-Hall, V Plagnol, TR Leahy, ... Science 342 (6160), 866-871, 2013 | 676 | 2013 |
| P-Rex1, a PtdIns (3, 4, 5) P3-and Gβγ-regulated guanine-nucleotide exchange factor for Rac HCE Welch, WJ Coadwell, CD Ellson, GJ Ferguson, SR Andrews, ... Cell 108 (6), 809-821, 2002 | 675 | 2002 |
| Structural insights into phosphoinositide 3-kinase catalysis and signalling EH Walker, O Perisic, C Ried, L Stephens, RL Williams Nature 402 (6759), 313-320, 1999 | 646 | 1999 |
| Agonist-stimulated synthesis of phosphatidylinositol (3, 4, 5)-trisphosphate: a new intracellular signalling system? LR Stephens, TR Jackson, PT Hawkins Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1179 (1), 27-75, 1993 | 632 | 1993 |
| Pathway of phosphatidylinositol (3, 4, 5)-trisphosphate synthesis in activated neutrophils LR Stephens, KT Hughes, RF Irvine Nature 351 (6321), 33-39, 1991 | 628 | 1991 |
| Activation of the small GTP-binding proteins rho and rac by growth factor receptors CD Nobes, P Hawkins, L Stephens, A Hall Journal of cell science 108 (1), 225-233, 1995 | 593 | 1995 |
| PI3K signalling in inflammation PT Hawkins, LR Stephens Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2015 | 569 | 2015 |
| Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling S Wennström, P Hawkins, F Cooke, K Hara, K Yonezawa, M Kasuga, ... Current Biology 4 (5), 385-393, 1994 | 555 | 1994 |
| 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. K Hara, K Yonezawa, H Sakaue, A Ando, K Kotani, T Kitamura, ... Proceedings of the National Academy of Sciences 91 (16), 7415-7419, 1994 | 533 | 1994 |
| Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B KE Anderson, J Coadwell, LR Stephens, PT Hawkins Current Biology 8 (12), 684-691, 1998 | 509 | 1998 |
| PtdIns (3) P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox CD Ellson, S Gobert-Gosse, KE Anderson, K Davidson, ... Nature cell biology 3 (7), 679-682, 2001 | 494 | 2001 |
